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* ID: [[id::birnlex_152]]
* Externally Sourced Definition: [[externallySourcedDefinition::Type: Inbred Strain Type: Segregating Inbred TJL Mating System: Sibling x Sibling (Female x Male) Species: laboratory mouse H2 Haplotype: b Generation: F155 (18-OCT-06) Appearance pink-eyed, light-bellied chinchilla Related Genotype: Aw/Aw p Tyrc-ch/p Tyrc-ch Important Note This strain is homozygous for Cdh23ahl, the age related hearing loss 1 mutation, which on this background results in progressive hearing loss with onset between 3 and 5 months of age. Strain Description For a complete history of the numerous 129 substrains please refer to Simpson, et al., 1997. Historically, the 129 inbred mice are known for the high incidence of spontaneous testicular teratomas, though the incidence differs between substrains. Most recently 129 mice are widely used strain in the production of targeted mutations due to the availability of several lines of embryonic stem cells. There is major genetic variation within the 129 "family", which has led to an update of the nomenclature and a division of substrains into three major groups: parental substrains, steel substrains and "ter" substrains. Investigators using 129 substrains for targeted mutagenesis should be careful in the selection of the appropriate 129 substrain to match the embryonic stem cell line.]]
* Definition Citation: [[definingCitation::Beck, J.A., et al., Genealogies of mouse inbred strains (2000), Nature, Jan2000, v24, p23]]
* Abbreviation: [[abbrev::129]]
* Abbreviation Source: [[abbrevSource::MGI]]
* Curation Status: [[curationStatus::pending_final_vetting]]
* Created Date: [[created::2007-08-15]]
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