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Carbenicillin

Name: Carbenicillin
Description: Broad-spectrum semisynthetic penicillin derivative used parenterally. It is susceptible to gastric juice and penicillinase and may damage platelet function. (PubChem) Pharmacology: Carbenicillin is a semisynthetic penicillin. Though carbenicillin provides substantial in vitro activity against a variety of both gram-positive and gram-negative microorganisms, the most important aspect of its profile is in its antipseudomonal and antiproteal activity. Because of the high urine levels obtained following administration, carbenicillin has demonstrated clinical efficacy in urinary infections due to susceptible strains of: Escherichia coli, Proteus mirabilis, Proteus vulgaris, Morganella morganii, Pseudomonas species, Providencia rettgeri, Enterobacter species, and Enterococci (S. faecalis). Mechanism of action: Free carbenicillin is the predominant pharmacologically active fraction of the salt. Carbenicillin exerts its antibacterial activity by interference with final cell wall synthesis of susceptible bacteria. Penicillins acylate the penicillin-sensitive transpeptidase C-terminal domain by opening the lactam ring. This inactivation of the enzyme prevents the formation of a cross-link of two linear peptidoglycan strands, inhibiting the third and last stage of bacterial cell wall synthesis. Cell lysis is then mediated by bacterial cell wall autolytic enzymes such as autolysins; it is possible that carbenicillin interferes with an autolysin inhibitor. Drug type: Approved. Small Molecule. Drug category: Anti-Bacterial Agents. Penicillins
Synonym(s): Carbenicilina (INN-Spanish), Carbenicillina (DCIT), Carbenicilline (INN-French), Carbenicillinum (INN-Latin), Carboxybenzylpenicillin, Carboxybenzylpenicillin acid, alpha-Carboxybenzylpencillin, Geopen, Pyopen
Related to: Penicillin-binding proteins 1A/1B
Has role: Drug
Super-category: Molecule
URL: http://www.drugbank.ca/drugs/DB00578
Id: CHEBI_3393
Link to OWL / RDF: Download this content as OWL/RDF




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Commenttaken from DrugBank
CurationStatusuncurated  +
CuratorAb  +
DefiningCitationhttp://www.drugbank.ca/drugs/DB00578  +
DefinitionBroad-spectrum semisynthetic penicillin de Broad-spectrum semisynthetic penicillin derivative used parenterally. It is susceptible to gastric juice and penicillinase and may damage platelet function. (PubChem) Pharmacology: Carbenicillin is a semisynthetic penicillin. Though carbenicillin provides substantial in vitro activity against a variety of both gram-positive and gram-negative microorganisms, the most important aspect of its profile is in its antipseudomonal and antiproteal activity. Because of the high urine levels obtained following administration, carbenicillin has demonstrated clinical efficacy in urinary infections due to susceptible strains of: Escherichia coli, Proteus mirabilis, Proteus vulgaris, Morganella morganii, Pseudomonas species, Providencia rettgeri, Enterobacter species, and Enterococci (S. faecalis). Mechanism of action: Free carbenicillin is the predominant pharmacologically active fraction of the salt. Carbenicillin exerts its antibacterial activity by interference with final cell wall synthesis of susceptible bacteria. Penicillins acylate the penicillin-sensitive transpeptidase C-terminal domain by opening the lactam ring. This inactivation of the enzyme prevents the formation of a cross-link of two linear peptidoglycan strands, inhibiting the third and last stage of bacterial cell wall synthesis. Cell lysis is then mediated by bacterial cell wall autolytic enzymes such as autolysins; it is possible that carbenicillin interferes with an autolysin inhibitor. Drug type: Approved. Small Molecule. Drug category: Anti-Bacterial Agents. Penicillins tegory: Anti-Bacterial Agents. Penicillins
Has roleDrug  +
IdCHEBI_3393  +
LabelCarbenicillin  +
ModifiedDate2 December 2010  +
RelatedToPenicillin-binding proteins 1A/1B  +
SuperCategoryMolecule  +
SynonymCarbenicilina (INN-Spanish)  +, Carbenicillina (DCIT)  +, Carbenicilline (INN-French)  +, Carbenicillinum (INN-Latin)  +, Carboxybenzylpenicillin  +, Carboxybenzylpenicillin acid  +, alpha-Carboxybenzylpencillin  +, Geopen  +, and Pyopen  +