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Fexofenadine

Name: Fexofenadine
Description: Fexofenadine hydrochloride (Allegra) is an antihistamine drug used in the treatment of hayfever and similar allergy symptoms. It was developed as a successor of and alternative to terfenadine. Fexofenadine, like other second and third-generation antihistamines, does not readily pass through the blood-brain barrier, and so causes less drowsiness than first-generation histamine-receptor antagonists. Pharmacology: Fexofenadine is a second-generation, long lasting H1-receptor antagonist (antihistamine) which has a selective and peripheral H1-antagonist action. Histamine is a chemical that causes many of the signs that are part of allergic reactions, for example, swelling of tissues. Histamine is released from histamine-storing cells (mast cells) and attaches to other cells that have receptors for histamine. The attachment of the histamine to the receptors causes the cell to be "activated," releasing other chemicals which produce the effects that we associate with allergy. Fexofenadine blocks one type of receptor for histamine (the H1 receptor) and thus prevents activation of cells by histamine. Unlike most other antihistamines, Fexofenadine does not enter the brain from the blood and, therefore, does not cause drowsiness. Fexofenadine lacks the cardiotoxic potential, since it does not block the potassium channel involved in repolarization of cardiac cells. Mechanism of action: Like other H1-blockers, Fexofenadine competes with free histamine for binding at H1-receptors in the GI tract, large blood vessels, and bronchial smooth muscle. This blocks the action of endogenous histamine, which subsequently leads to temporary relief of the negative symptoms brought on by histamine. Fexofenadine exhibits no anticholinergic, alpha1-adrenergic or beta-adrenergic-receptor blocking effects. Drug type: Approved. Small Molecule. Drug category: Anti-Allergic Agents. Antihistamines. Histamine H1 Antagonists, Non-Sedating
Synonym(s): Carboxyterfenadine, Fexofenadine hydrochloride, Fexofendine, Terfenadine acid metabolite, Terfenadine carboxylate, Terfenadine-COOH, Allegra
Has role: Drug
Super-category: Molecule
URL: http://www.drugbank.ca/drugs/DB00950
*Id: CHEBI: 5050
Related to: Histamine H1 receptor
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Facts about FexofenadineRDF feed
Commenttaken from DrugBank
CurationStatusuncurated  +
CuratorAb  +
DefiningCitationhttp://www.drugbank.ca/drugs/DB00950  +
DefinitionFexofenadine hydrochloride (Allegra) is an Fexofenadine hydrochloride (Allegra) is an antihistamine drug used in the treatment of hayfever and similar allergy symptoms. It was developed as a successor of and alternative to terfenadine. Fexofenadine, like other second and third-generation antihistamines, does not readily pass through the blood-brain barrier, and so causes less drowsiness than first-generation histamine-receptor antagonists. Pharmacology: Fexofenadine is a second-generation, long lasting H1-receptor antagonist (antihistamine) which has a selective and peripheral H1-antagonist action. Histamine is a chemical that causes many of the signs that are part of allergic reactions, for example, swelling of tissues. Histamine is released from histamine-storing cells (mast cells) and attaches to other cells that have receptors for histamine. The attachment of the histamine to the receptors causes the cell to be "activated," releasing other chemicals which produce the effects that we associate with allergy. Fexofenadine blocks one type of receptor for histamine (the H1 receptor) and thus prevents activation of cells by histamine. Unlike most other antihistamines, Fexofenadine does not enter the brain from the blood and, therefore, does not cause drowsiness. Fexofenadine lacks the cardiotoxic potential, since it does not block the potassium channel involved in repolarization of cardiac cells. Mechanism of action: Like other H1-blockers, Fexofenadine competes with free histamine for binding at H1-receptors in the GI tract, large blood vessels, and bronchial smooth muscle. This blocks the action of endogenous histamine, which subsequently leads to temporary relief of the negative symptoms brought on by histamine. Fexofenadine exhibits no anticholinergic, alpha1-adrenergic or beta-adrenergic-receptor blocking effects. Drug type: Approved. Small Molecule. Drug category: Anti-Allergic Agents. Antihistamines. Histamine H1 Antagonists, Non-Sedating es. Histamine H1 Antagonists, Non-Sedating
Has roleDrug  +
IdCHEBI: 5050  +
LabelFexofenadine  +
ModifiedDate17 March 2010  +
RelatedToHistamine H1 receptor  +
SuperCategoryMolecule  +
SynonymCarboxyterfenadine  +, Fexofenadine hydrochloride  +, Fexofendine  +, Terfenadine acid metabolite  +, Terfenadine carboxylate  +, Terfenadine-COOH  +, and Allegra  +