EditFrom NeuroLex
Loxapine
| Name: | Loxapine |
| Description: | An antipsychotic agent used in schizophrenia. (PubChem) Pharmacology: Loxapine, a dibenzoxazepine compound, represents a subclass of tricyclic antipsychotic agents, chemically distinct from the thioxanthenes, butyrophenones, and phenothiazines. Pharmacologically, Loxapine is a tranquilizer for which the exact mode of action has not been established. Mechanism of action: Loxapine is a dopamine antagonist, and also a serotonin 5-HT2 blocker. The exact mode of action of Loxapine has not been established, however changes in the level of excitability of subcortical inhibitory areas have been observed in several animal species in association with such manifestations of tranquilization as calming effects and suppression of aggressive behavior. Drug type: Approved. Small Molecule. Drug category: Antipsychotic Agents. Antipsychotics. Dopamine Antagonists |
| Synonym(s): | Cloxazepine, Dibenzacepin, Dibenzoazepine, Hydrofluoride 3170, Lossapina (Dcit), Loxapac, Loxapin, Loxapina (INN-Spanish), Loxapine (Usan:Ban:Inn), Loxapinum (INN-Latin), Loxepine, Loxitane C, Loxitane Im, Oxilapine |
| Related to: | D(1A) dopamine receptor, D(2) dopamine receptor |
| Has role: | Drug |
| Super-category: | Molecule |
| URL: | http://www.drugbank.ca/drugs/DB00408 |
| Id: | CHEBI: 50841 |
| Link to OWL / RDF: | Download this content as OWL/RDF |
Facts about LoxapineRDF feed
| Comment | taken from DrugBank |
| CurationStatus | uncurated + |
| Curator | Ab + |
| DefiningCitation | http://www.drugbank.ca/drugs/DB00408 + |
| Definition | An antipsychotic agent used in schizophren … An antipsychotic agent used in schizophrenia. (PubChem) Pharmacology: Loxapine, a dibenzoxazepine compound, represents a subclass of tricyclic antipsychotic agents, chemically distinct from the thioxanthenes, butyrophenones, and phenothiazines. Pharmacologically, Loxapine is a tranquilizer for which the exact mode of action has not been established. Mechanism of action: Loxapine is a dopamine antagonist, and also a serotonin 5-HT2 blocker. The exact mode of action of Loxapine has not been established, however changes in the level of excitability of subcortical inhibitory areas have been observed in several animal species in association with such manifestations of tranquilization as calming effects and suppression of aggressive behavior. Drug type: Approved. Small Molecule. Drug category: Antipsychotic Agents. Antipsychotics. Dopamine Antagonists ents. Antipsychotics. Dopamine Antagonists |
| Has role | Drug + |
| Id | CHEBI: 50841 + |
| Label | Loxapine + |
| ModifiedDate | 16 March 2010 + |
| RelatedTo | D(1A) dopamine receptor +, and D(2) dopamine receptor + |
| SuperCategory | Molecule + |
| Synonym | Cloxazepine +, Dibenzacepin +, Dibenzoazepine +, Hydrofluoride 3170 +, Lossapina (Dcit) +, Loxapac +, Loxapin +, Loxapina (INN-Spanish) +, Loxapine (Usan:Ban:Inn) +, Loxapinum (INN-Latin) +, Loxepine +, Loxitane C +, Loxitane Im +, and Oxilapine + |