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Mechlorethamine

Name: Mechlorethamine
Description: A vesicant and necrotizing irritant destructive to mucous membranes. It was formerly used as a war gas. The hydrochloride is used as an antineoplastic in Hodgkin's disease and lymphomas. It causes severe gastrointestinal and bone marrow damage. (PubChem) Pharmacology: Mechlorethamine also known as mustine, nitrogen mustard, and HN2, is the prototype anticancer chemotherapeutic drug. Successful clinical use of mechlorethamine gave birth to the field of anticancer chemotherapy. The drug is an analogue of mustard gas and was derived from toxic gas warfare research. It belongs to the group of nitrogen mustard alkylating agents. Alkylating agents work by three different mechanisms all of which achieve the same end result - disruption of DNA function and cell death. Mechanism of action: Alkylating agents work by three different mechanisms: 1) attachment of alkyl groups to DNA bases, resulting in the DNA being fragmented by repair enzymes in their attempts to replace the alkylated bases, preventing DNA synthesis and RNA transcription from the affected DNA, 2) DNA damage via the formation of cross-links (bonds between atoms in the DNA) which prevents DNA from being separated for synthesis or transcription, and 3) the induction of mispairing of the nucleotides leading to mutations. Mechlorethamine is cell cycle phase-nonspecific. Drug type: Approved. Small Molecule. Drug category: Alkylating Agents. Antineoplastic Agents, Alkylating. Chemical Warfare Agents. Irritants
Synonym(s): Chlorethazine, Chlormethine, HN2, MBA, Mechloroethamine, Mecloretamina, Mustine, Nitrogen mustard, Caryolysin, Caryolysine, Cloramin, Dichloren, Embichin, Mustargen, Mutagen
Has role: Drug
Super-category: Molecule
URL: http://www.drugbank.ca/drugs/DB00888
Id: CHEBI: 28925
Related to: DNA
Link to OWL / RDF: Download this content as OWL/RDF


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Bandrow, Ccdbuser, Nifbot2, Whetzel



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Facts about MechlorethamineRDF feed
Commenttaken from DrugBank
CurationStatusuncurated  +
CuratorAb  +
DefiningCitationhttp://www.drugbank.ca/drugs/DB00888  +
DefinitionA vesicant and necrotizing irritant destru A vesicant and necrotizing irritant destructive to mucous membranes. It was formerly used as a war gas. The hydrochloride is used as an antineoplastic in Hodgkin's disease and lymphomas. It causes severe gastrointestinal and bone marrow damage. (PubChem) Pharmacology: Mechlorethamine also known as mustine, nitrogen mustard, and HN2, is the prototype anticancer chemotherapeutic drug. Successful clinical use of mechlorethamine gave birth to the field of anticancer chemotherapy. The drug is an analogue of mustard gas and was derived from toxic gas warfare research. It belongs to the group of nitrogen mustard alkylating agents. Alkylating agents work by three different mechanisms all of which achieve the same end result - disruption of DNA function and cell death. Mechanism of action: Alkylating agents work by three different mechanisms: 1) attachment of alkyl groups to DNA bases, resulting in the DNA being fragmented by repair enzymes in their attempts to replace the alkylated bases, preventing DNA synthesis and RNA transcription from the affected DNA, 2) DNA damage via the formation of cross-links (bonds between atoms in the DNA) which prevents DNA from being separated for synthesis or transcription, and 3) the induction of mispairing of the nucleotides leading to mutations. Mechlorethamine is cell cycle phase-nonspecific. Drug type: Approved. Small Molecule. Drug category: Alkylating Agents. Antineoplastic Agents, Alkylating. Chemical Warfare Agents. Irritants lating. Chemical Warfare Agents. Irritants
Has roleDrug  +
IdCHEBI: 28925  +
LabelMechlorethamine  +
ModifiedDate16 March 2010  +
RelatedToDNA  +
SuperCategoryMolecule  +
SynonymChlorethazine  +, Chlormethine  +, HN2  +, MBA  +, Mechloroethamine  +, Mecloretamina  +, Mustine  +, Nitrogen mustard  +, Caryolysin  +, Caryolysine  +, Cloramin  +, Dichloren  +, Embichin  +, Mustargen  +, and Mutagen  +