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PINK1 Mutant Drosophila

Name: PINK1 Mutant Drosophila
Description: This fly shows a mutation in PTEN induced kinase 1 (PINK1). Loss of function of PINK1 causes many symptoms similar to human Parkinson's disease. Common phenotypes show mitochondrial structural defects, reduced ATP content, and alpha-synuclein aggregation. This mutation is used to study Parkinson's disease in the laboratory.
PMID: PMID 19242547
Id: nlx_organ_090707
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Contributors

Laurenthompson214, Mimam



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AuthorsWencheng Liu  +, Cristofol Vives-Bauza  +, Rebeca Acin-Perez  +, Ai Yamamoto  +, Yingcai Tan  +, Yanping Li  +, Jordi Magrane  +, Mihaela A. Atavarache  +, Sebastian Shaffer  +, Simon Chang  +, Michael G. Kaplitt  +, Xin-Yun Huang  +, M. Flint Beal  +, Giovanni Manfredi  +, and Chenjain Li  +
CurationStatusuncurated  +
DefinitionThis fly shows a mutation in PTEN induced This fly shows a mutation in PTEN induced kinase 1 (PINK1). Loss of function of PINK1 causes many symptoms similar to human Parkinson's disease. Common phenotypes show mitochondrial structural defects, reduced ATP content, and alpha-synuclein aggregation. This mutation is used to study Parkinson's disease in the laboratory. udy Parkinson's disease in the laboratory.
Figure5  +, 9  +, and 11  +
Idnlx_organ_090707  +
JournalNumber2  +
JournalVolume4  +
LabelPINK1 Mutant Drosophila  +
ModifiedDate28 October 2009  +
PMID19242547  +
Pages1-14
PublicationDateFebruary 2009  +
PublicationNamePLoS ONE  +
TitlePINK1 Defect Causes Mitochondrial Dysfunction  +, and Proteasomal Deficit and Alpha-Synuclein Aggregation in Cell Culture Models of Parkinson's Disease  +