EditFrom NeuroLex
Phenylalanine-4-hydroxylase
| Name: | Phenylalanine-4-hydroxylase |
| Description: | Phenylalanine hydroxylase (EC 1.14.16.1) is an enzyme which catalyses the reaction responsible for the addition of a hydroxyl group to the end of the 6-carbon aromatic ring of phenylalanine, such that it becomes tyrosine. Phenylalanine hydroxylase is the rate-limiting enzyme of the metabolic pathway which degrades excess phenylalanine. The PAH gene or a 1:1 ortholog thereof encodes for phenylalanine hydroxylase. |
| Synonym(s): | Phe-4-monooxygenase, Phenylalanine hydroxylase |
| Is part of: | Catecholamine system, Adrenergic system, Dopaminergic system, Noradrenergic system |
| Related to: | Tyrosine, Phenylalanine |
| Has role: | Enzyme |
| Abbreviation: | PAH |
| Super-category: | Protein |
| URL: | Kaufman, D (1 February 1958). "A New Cofactor Required for the Enzymatic Conversion of Phenylalanine to Tyrosine.". J. Biol. Chem. 230 (230): 931–39. |
| PMID: | PMID 13525410 |
| Id: | PRO:000012234 |
| Link to OWL / RDF: | Download this content as OWL/RDF |
Categories related to Phenylalanine-4-hydroxylase
Epinephrine, L-Phenylalanine, Levodopa, Norepinephrine, Tetrahydrobiopterin
Facts about Phenylalanine-4-hydroxylaseRDF feed
| Abbrev | PAH + |
| CurationStatus | uncurated + |
| DefiningCitation | Kaufman, D (1 February 1958). "A New Cofactor Required for the Enzymatic Conversion of Phenylalanine to Tyrosine.". J. Biol. Chem. 230 (230): 931–39. + |
| Definition | Phenylalanine hydroxylase (EC 1.14.16.1) i … Phenylalanine hydroxylase (EC 1.14.16.1) is an enzyme which catalyses the reaction responsible for the addition of a hydroxyl group to the end of the 6-carbon aromatic ring of phenylalanine, such that it becomes tyrosine. Phenylalanine hydroxylase is the rate-limiting enzyme of the metabolic pathway which degrades excess phenylalanine. The PAH gene or a 1:1 ortholog thereof encodes for phenylalanine hydroxylase. eof encodes for phenylalanine hydroxylase. |
| Has role | Enzyme + |
| Id | PRO:000012234 + |
| Is part of | Catecholamine system +, Adrenergic system +, Dopaminergic system +, and Noradrenergic system + |
| Label | Phenylalanine-4-hydroxylase + |
| ModifiedDate | 1 May 2010 + |
| PMID | 13525410 + |
| RelatedTo | Tyrosine +, and Phenylalanine + |
| SuperCategory | Protein + |
| Synonym | Phe-4-monooxygenase +, and Phenylalanine hydroxylase + |