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Phenylalanine-4-hydroxylase

Name: Phenylalanine-4-hydroxylase
Description: Phenylalanine hydroxylase (EC 1.14.16.1) is an enzyme which catalyses the reaction responsible for the addition of a hydroxyl group to the end of the 6-carbon aromatic ring of phenylalanine, such that it becomes tyrosine. Phenylalanine hydroxylase is the rate-limiting enzyme of the metabolic pathway which degrades excess phenylalanine. The PAH gene or a 1:1 ortholog thereof encodes for phenylalanine hydroxylase.
Synonym(s): Phe-4-monooxygenase, Phenylalanine hydroxylase
Abbreviation: PAH
Is part of: Catecholamine system, Adrenergic system, Dopaminergic system, Noradrenergic system
Has role: Enzyme
Super-category: Protein
URL: Kaufman, D (1 February 1958). "A New Cofactor Required for the Enzymatic Conversion of Phenylalanine to Tyrosine.". J. Biol. Chem. 230 (230): 931–39.
Id: PRO:000012234
PMID: PMID 13525410
Related to: Tyrosine, Phenylalanine
Link to OWL / RDF: Download this content as OWL/RDF

Categories related to Phenylalanine-4-hydroxylase

Epinephrine, L-Phenylalanine, Levodopa, Norepinephrine, Tetrahydrobiopterin


Contributors

Ayeliset, Zaidaziz



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Facts about Phenylalanine-4-hydroxylaseRDF feed
AbbrevPAH  +
CurationStatusuncurated  +
DefiningCitationKaufman, D (1 February 1958). "A New Cofactor Required for the Enzymatic Conversion of Phenylalanine to Tyrosine.". J. Biol. Chem. 230 (230): 931–39.  +
DefinitionPhenylalanine hydroxylase (EC 1.14.16.1) i Phenylalanine hydroxylase (EC 1.14.16.1) is an enzyme which catalyses the reaction responsible for the addition of a hydroxyl group to the end of the 6-carbon aromatic ring of phenylalanine, such that it becomes tyrosine. Phenylalanine hydroxylase is the rate-limiting enzyme of the metabolic pathway which degrades excess phenylalanine. The PAH gene or a 1:1 ortholog thereof encodes for phenylalanine hydroxylase. eof encodes for phenylalanine hydroxylase.
Has roleEnzyme  +
IdPRO:000012234  +
Is part ofCatecholamine system  +, Adrenergic system  +, Dopaminergic system  +, and Noradrenergic system  +
LabelPhenylalanine-4-hydroxylase  +
ModifiedDate1 May 2010  +
PMID13525410  +
RelatedToTyrosine  +, and Phenylalanine  +
SuperCategoryProtein  +
SynonymPhe-4-monooxygenase  +, and Phenylalanine hydroxylase  +