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Resource:Brain Research Institute Research Resources

Name: Resource:Brain Research Institute Research Resources
Description: Publicly available brain bank resources which include "Postmortem Human Frozen Brain Tissue and Matched Cerebrospinal Fluid (CSF) and Blood are Available for Scientists to Search for Etiopathogeneses of Human Disease" and "Alzheimer's Disease Brain Tissue and CSF."

RESOURCE #1: POSTMORTEM HUMAN FROZEN BRAIN TISSUE AND MATCHED CEREBROSPINAL FLUID (CSF) AND BLOOD ARE AVAILABLE FOR SCIENTISTS TO SEARCH FOR ETIPATHOGENESES OF HUMAN DISEASE.

The National Neurological Research Specimen Bank and the Multiple Sclerosis Human Neurospecimen Bank maintains a collection of quick frozen and formalin fixed postmortem human brain tissue and frozen cerebrospinal fluid (CSF) from patients with neurological diseases (including Alzheimer's Disease, amyotrophic lateral sclerosis, depressive disorder/suicide, epilepsy, Huntington's disease, multiple sclerosis, Parkinson's Disease, progressive supranuclear palsy, schizophrenia, stroke/CVA and other less common diseases). Full inventory is available upon request. Diagnoses are documented by clinical medical records and gross/microscopic neuropathology.

Special features of the Bank are as follows:

  1. Serial digital images of coronal sections (7 mm thick and obtained before quick freezing) are available for selecting samples to be studied.
  2. Microscopic neuropathology is available on each dissected sample and the dissected sample's localization is sketched on the gross coronal section image from which it came.
  3. Plaques of demyelination are classified as active, chronic active or inactive, and a shipment includes adjacent normal appearing white and nearby gray matter from the same case (they serve as a type of control).
  4. Ice artifact is minimized and it does not interfere with in situ hybridization or in situ PCR or immunocytochemistry.
  5. Tissue samples have been used for harvesting enough mRNA for microarray assay plates.
  6. CSF cells and cell-free CSF are available pre- and postmortem as is serum, plasma and buffy coats. They are stored quick frozen (full inventory is available upon request).

RESOURCE #2: ALZHEIMER'S DISEASE BRAIN TISSUE AND CSF

The Neuropathology Laboratory at UCLA Medical Center maintains a bank of frozen, formalin and paraformaldehyde-fixed and paraffin-embedded postmortem human brain tissues and frozen cerebrospinal fluid (CSF) from patients who die with Alzheimer's disease and other dementing and degenerative illnesses (including progressive supranuclear palsy, Parkinson's disease, fronto-temporal dementia), as well as control materials removed in a similar fashion from patients who are neurologically normal. Tissues are maintained as part of the NIA-funded Neuropathology Core functions of the UCLA Alzheimer's Disease Center. These tissues/fluids are available as a resource to investigators in any discipline. Pilot studies using the tissues/CSF to examine biomolecules that are of known importance in animal models and suspected significance in human neurodegenerative conditions are particularly encouraged. Every attempt will be made to provide research materials for worthwhile projects in a timely fashion.
Parent Organization: Resource:Brain Research Institute
Supporting Agency: NINDS, NIMH, Resource:National MS Society, United States Department of Veterans Affairs, (Veterans Affairs West Los Angeles Healthcare Center), NIA
Related to: Resource:One Mind Biospecimen Bank Listing, US Biobank
Resource Type(s): Brain bank, Biomaterial supply resource, Image collection, Data or information resource
Keywords: Postmortem, Brain, Coronal, Brain tissue, Cerebral Spinal Fluid, Blood, Cerebral Spinal Fluid cell, Cell-free Cerebral Spinal Fluid, Serum, Plasma, Buffy coat, Frozen, Formalin fixed, Paraformaldehyde-fixed, Paraffin-embedded, Neurological disease, Alzheimer's disease, Amyotrophic Lateral Sclerosis, Depressive Disorder, Suicide, Epilepsy, Huntington's disease, Multiple Sclerosis, Parkinson's disease, Progressive Supranuclear Palsy, Schizophrenia, Stroke, Cerebrovascular Accident, Fronto-temporal dementia, Neurologically normal, Coronal section, Control, Clinical data
Abbreviation: BRI Research Resources
Resource: Resource
URL: http://www.bri.ucla.edu/bri_research/research_resources.asp
Related condition/disease: Neurological disease, Alzheimer's disease, Amyotrophic Lateral Sclerosis, Depressive Disorder, Suicide, Epilepsy, Huntington's disease, Multiple Sclerosis, Parkinson's disease, Progressive Supranuclear Palsy, Schizophrenia, Stroke, Cerebrovascular Accident, Fronto-temporal dementia, Neurologically normal, Control
Related application: Research
Processing: Frozen, Formalin fixed, Paraformaldehyde-fixed, Paraffin-embedded
Availability: Public: Postmortem Human Frozen Brain Tissue and Matched Cerebrospinal Fluid (CSF) and Blood are Available for Scientists to Search for Etiopathogeneses of Human Disease in any discipline.
Address: Address #1:Neurology Research (127A), VA West Los Angeles Healthcare Center, 11301 Wilshire Blvd, Los Angeles, CA 90073 Telephone:(310) 268_4638 Fax: (310) 268_4638 Wallace W. Tourtellotte, M.D., Ph.D., E-mail: wtourtel at ucla.edu; Address #2: Section of Neuropathology, UCLA Medical Center, CHS 18-170, Los Angeles, CA 90095-1732 Phone: 310-825-6191 Fax: 310-206-829 Dr. Harry Vinters, E-mail: hvinters (at) mednet.ucla.edu
Id: nlx_143996
Organism: Human
Link to OWL / RDF: Download this content as OWL/RDF

Curation status: Uncurated

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Facts about Resource:Brain Research Institute Research ResourcesRDF feed
AbbrevBRI Research Resources  +
AddressAddress #1:Neurology Research (127A)  +, VA West Los Angeles Healthcare Center  +, 11301 Wilshire Blvd  +, Los Angeles  +, CA 90073 Telephone:(310) 268_4638 Fax: (310) 268_4638 Wallace W. Tourtellotte  +, M.D.  +, Ph.D.  +, E-mail: wtourtel at ucla.edu; Address #2: Section of Neuropathology  +, UCLA Medical Center  +, CHS 18-170  +, CA 90095-1732 Phone: 310-825-6191 Fax: 310-206-829 Dr. Harry Vinters  +, and E-mail: hvinters (at) mednet.ucla.edu  +
AvailabilityPublic: Postmortem Human Frozen Brain Tissue and Matched Cerebrospinal Fluid (CSF) and Blood are Available for Scientists to Search for Etiopathogeneses of Human Disease in any discipline.  +
CommentSample type: Brain tissue, Brain, Cerebral Spinal Fluid, Blood, Cerebral Spinal Fluid cell, Cell-free Cerebral Spinal Fluid, Serum, Plasma, Buffy coat
CurationStatuscurated  +
DefiningCitationhttp://www.bri.ucla.edu/bri_research/research_resources.asp  +
DefinitionPublicly available brain bank resources wh Publicly available brain bank resources which include "Postmortem Human Frozen Brain Tissue and Matched Cerebrospinal Fluid (CSF) and Blood are Available for Scientists to Search for Etiopathogeneses of Human Disease" and "Alzheimer's Disease Brain Tissue and CSF."

RESOURCE #1: POSTMORTEM HUMAN FROZEN BRAIN TISSUE AND MATCHED CEREBROSPINAL FLUID (CSF) AND BLOOD ARE AVAILABLE FOR SCIENTISTS TO SEARCH FOR ETIPATHOGENESES OF HUMAN DISEASE.

The National Neurological Research Specimen Bank and the Multiple Sclerosis Human Neurospecimen Bank maintains a collection of quick frozen and formalin fixed postmortem human brain tissue and frozen cerebrospinal fluid (CSF) from patients with neurological diseases (including Alzheimer's Disease, amyotrophic lateral sclerosis, depressive disorder/suicide, epilepsy, Huntington's disease, multiple sclerosis, Parkinson's Disease, progressive supranuclear palsy, schizophrenia, stroke/CVA and other less common diseases). Full inventory is available upon request. Diagnoses are documented by clinical medical records and gross/microscopic neuropathology.

Special features of the Bank are as follows:

  1. Serial digital images of coronal sections (7 mm thick and obtained before quick freezing) are available for selecting samples to be studied.
  2. Microscopic neuropathology is available on each dissected sample and the dissected sample's localization is sketched on the gross coronal section image from which it came.
  3. Plaques of demyelination are classified as active, chronic active or inactive, and a shipment includes adjacent normal appearing white and nearby gray matter from the same case (they serve as a type of control).
  4. Ice artifact is minimized and it does not interfere with in situ hybridization or in situ PCR or immunocytochemistry.
  5. Tissue samples have been used for harvesting enough mRNA for microarray assay plates.
  6. CSF cells and cell-free CSF are available pre- and postmortem as is serum, plasma and buffy coats. They are stored quick frozen (full inventory is available upon request).

RESOURCE #2: ALZHEIMER'S DISEASE BRAIN TISSUE AND CSF

The Neuropathology Laboratory at UCLA Medical Center maintains a bank of frozen, formalin and paraformaldehyde-fixed and paraffin-embedded postmortem human brain tissues and frozen cerebrospinal fluid (CSF) from patients who die with Alzheimer's disease and other dementing and degenerative illnesses (including progressive supranuclear palsy, Parkinson's disease, fronto-temporal dementia), as well as control materials removed in a similar fashion from patients who are neurologically normal. Tissues are maintained as part of the NIA-funded Neuropathology Core functions of the UCLA Alzheimer's Disease Center. These tissues/fluids are available as a resource to investigators in any discipline. Pilot studies using the tissues/CSF to examine biomolecules that are of known importance in animal models and suspected significance in human neurodegenerative conditions are particularly encouraged. Every attempt will be made to provide research materials for worthwhile projects in a timely fashion.
r worthwhile projects in a timely fashion.
ExampleImageBRI Research Resources.PNG  +
Has default formThis property is a special property in this wiki.Resource  +
Has roleBrain bank  +, Biomaterial supply resource  +, Image collection  +, and Data or information resource  +
Idnlx_143996  +
Is part ofResource:Brain Research Institute  +
KeywordsPostmortem  +, Brain  +, Coronal  +, Brain tissue  +, Cerebral Spinal Fluid  +, Blood  +, Cerebral Spinal Fluid cell  +, Cell-free Cerebral Spinal Fluid  +, Serum  +, Plasma  +, Buffy coat  +, Frozen  +, Formalin fixed  +, Paraformaldehyde-fixed  +, Paraffin-embedded  +, Neurological disease  +, Alzheimer's disease  +, Amyotrophic Lateral Sclerosis  +, Depressive Disorder  +, Suicide  +, Epilepsy  +, Huntington's disease  +, Multiple Sclerosis  +, Parkinson's disease  +, Progressive Supranuclear Palsy  +, Schizophrenia  +, Stroke  +, Cerebrovascular Accident  +, Fronto-temporal dementia  +, Neurologically normal  +, Coronal section  +, Control  +, and Clinical data  +
LabelResource:Brain Research Institute Research Resources  +
ModifiedDate21 June 2013  +
Page has default formThis property is a special property in this wiki.Resource  +
ProcessingFrozen  +, Formalin fixed  +, Paraformaldehyde-fixed  +, and Paraffin-embedded  +
RelatedToResource:One Mind Biospecimen Bank Listing  +, and US Biobank  +
Related applicationResearch  +
Related diseaseNeurological disease  +, Alzheimer's disease  +, Amyotrophic Lateral Sclerosis  +, Depressive Disorder  +, Suicide  +, Epilepsy  +, Huntington's disease  +, Multiple Sclerosis  +, Parkinson's disease  +, Progressive Supranuclear Palsy  +, Schizophrenia  +, Stroke  +, Cerebrovascular Accident  +, Fronto-temporal dementia  +, Neurologically normal  +, and Control  +
SpeciesHuman  +
SuperCategoryResource  +
Supporting AgencyNINDS  +, NIMH  +, Resource:National MS Society  +, United States Department of Veterans Affairs  +, (Veterans Affairs West Los Angeles Healthcare Center)  +, and NIA  +