RESOURCE #1: POSTMORTEM HUMAN FROZEN BRAIN TISSUE AND MATCHED CEREBROSPINAL FLUID (CSF) AND BLOOD ARE AVAILABLE FOR SCIENTISTS TO SEARCH FOR ETIPATHOGENESES OF HUMAN DISEASE.

The National Neurological Research Specimen Bank and the Multiple Sclerosis Human Neurospecimen Bank maintains a collection of quick frozen and formalin fixed postmortem human brain tissue and frozen cerebrospinal fluid (CSF) from patients with neurological diseases (including Alzheimer's Disease, amyotrophic lateral sclerosis, depressive disorder/suicide, epilepsy, Huntington's disease, multiple sclerosis, Parkinson's Disease, progressive supranuclear palsy, schizophrenia, stroke/CVA and other less common diseases). Full inventory is available upon request. Diagnoses are documented by clinical medical records and gross/microscopic neuropathology.

Special features of the Bank are as follows:

1. Serial digital images of coronal sections (7 mm thick and obtained before quick freezing) are available for selecting samples to be studied.
   
2. Microscopic neuropathology is available on each dissected sample and the dissected sample's localization is sketched on the gross coronal section image from which it came.
   
3. Plaques of demyelination are classified as active, chronic active or inactive, and a shipment includes adjacent normal appearing white and nearby gray matter from the same case (they serve as a type of control).
   
4. Ice artifact is minimized and it does not interfere with in situ hybridization or in situ PCR or immunocytochemistry.
   
5. Tissue samples have been used for harvesting enough mRNA for microarray assay plates.
   
6. CSF cells and cell-free CSF are available pre- and postmortem as is serum, plasma and buffy coats. They are stored quick frozen (full inventory is available upon request).
   

RESOURCE #2: ALZHEIMER'S DISEASE BRAIN TISSUE AND CSF