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Resource:Comparative Toxicogenomics Database

Name: Resource:Comparative Toxicogenomics Database
Description: The Comparative Toxicogenomics Database (CTD) is a public database that enhances understanding about the effects of environmental chemicals on human health. Integrated GO data and a GO browser add functionality to CTD by allowing users to understand biological functions, processes and cellular locations that are the targets of chemical exposures.

The etiology of most chronic diseases involves interactions between environmental factors and genes that modulate important physiological processes. This assumption is supported by the many complex diseases caused by reversible behaviors or avoidable exposures, and by the relatively rare number of diseases attributed to single gene mutations. Environmental factors are implicated in many common conditions such as asthma, cancer, diabetes, hypertension, immune deficiency disorders, and Parkinson’s disease. The molecular mechanisms underlying these correlations, however, are not well understood.

CTD includes curated data describing cross-species chemical–gene/protein interactions and chemical– and gene–disease associations to illuminate molecular mechanisms underlying variable susceptibility and environmentally influenced diseases. These data will also provide insights into complex chemical–gene and protein interaction networks.

Discover.

  1. What human diseases are associated with a gene/protein?
  2. What human diseases are associated with a chemical?
  3. What genes/proteins interact with a chemical?
  4. What chemicals interact with a gene/protein?
  5. What references report a chemical–gene/protein interaction?
  6. What cellular functions (GO terms) are affected by a chemical?
Platform: Online
Other Name(s): CTD - Comparative Toxicogenomics Database
Parent Organization: Resource:Mount Desert Island Biological Laboratory, North Carolina State University; North Carolina; USA
Supporting Agency: National Institute of Environmental Health Sciences, National Center for Research Resources, Pfizer, American Chemistry Council
Related to: Resource:Gene Ontology Tools, Resource:GO
Resource Type(s): Database, Data analysis service
Keywords: Environment, Chemical, Disease, Gene, Pathway, Protein, Interaction, Animal model, ontology or annotation browser
Grant: ES014065, R01 ES019604, P20 RR016463
Abbreviation: CTD
Resource: Resource
URL: http://ctd.mdibl.org
PMID: PMID 16902965, 16675512, 14735110, 12760826,
Availability: Free for academic use
Id: nif-0000-02683
Organism: Human, Mouse, Rat, Chicken, Zebrafish, Dog
Link to OWL / RDF: Download this content as OWL/RDF

Categories related to Resource:Comparative Toxicogenomics Database

Resource:BioRAT, Resource:DisGeNET, Resource:Integrated Gene-Disease Interaction, Resource:Integrated Manually Extracted Annotation

Curation status: Curated

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Notes

This page uses this default form:Resource



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Facts about Resource:Comparative Toxicogenomics DatabaseRDF feed
AbbrevCTD  +
AvailabilityFree for academic use  +
CurationStatuscurated  +
DefiningCitationhttp://ctd.mdibl.org  +
DefinitionThe Comparative Toxicogenomics Database (C The Comparative Toxicogenomics Database (CTD) is a public database that enhances understanding about the effects of environmental chemicals on human health. Integrated GO data and a GO browser add functionality to CTD by allowing users to understand biological functions, processes and cellular locations that are the targets of chemical exposures.

The etiology of most chronic diseases involves interactions between environmental factors and genes that modulate important physiological processes. This assumption is supported by the many complex diseases caused by reversible behaviors or avoidable exposures, and by the relatively rare number of diseases attributed to single gene mutations. Environmental factors are implicated in many common conditions such as asthma, cancer, diabetes, hypertension, immune deficiency disorders, and Parkinson’s disease. The molecular mechanisms underlying these correlations, however, are not well understood.

CTD includes curated data describing cross-species chemical–gene/protein interactions and chemical– and gene–disease associations to illuminate molecular mechanisms underlying variable susceptibility and environmentally influenced diseases. These data will also provide insights into complex chemical–gene and protein interaction networks.

Discover.

  1. What human diseases are associated with a gene/protein?
  2. What human diseases are associated with a chemical?
  3. What genes/proteins interact with a chemical?
  4. What chemicals interact with a gene/protein?
  5. What references report a chemical–gene/protein interaction?
  6. What cellular functions (GO terms) are affected by a chemical?

Platform: Online affected by a chemical?

Platform: Online
ExampleImageCTD.PNG  +
GrantCategory:ES014065   +, Category:R01 ES019604   +, and Category:P20 RR016463   +
Has default formThis property is a special property in this wiki.Resource  +
Has roleDatabase  +, and Data analysis service  +
Idnif-0000-02683  +
Is part ofResource:Mount Desert Island Biological Laboratory  +, and North Carolina State University; North Carolina; USA  +
KeywordsEnvironment  +, Chemical  +, Disease  +, Gene  +, Pathway  +, Protein  +, Interaction  +, Animal model  +, and Ontology or annotation browser  +
LabelResource:Comparative Toxicogenomics Database  +
ModifiedDate20 July 2012  +
PMID16902965, 16675512, 14735110, 12760826,  +
Page has default formThis property is a special property in this wiki.Resource  +
RelatedToResource:Gene Ontology Tools  +, and Resource:GO  +
SpeciesHuman  +, Mouse  +, Rat  +, Chicken  +, Zebrafish  +, and Dog  +
SuperCategoryResource  +
Supporting AgencyNational Institute of Environmental Health Sciences  +, National Center for Research Resources  +, Pfizer  +, and American Chemistry Council  +
SynonymCTD - Comparative Toxicogenomics Database  +