Edit draftFrom NeuroLex
Resource:Comparative Toxicogenomics Database
| Name: | Resource:Comparative Toxicogenomics Database |
| Description: | The Comparative Toxicogenomics Database (CTD) is a public database that enhances understanding about the effects of environmental chemicals on human health. Integrated GO data and a GO browser add functionality to CTD by allowing users to understand biological functions, processes and cellular locations that are the targets of chemical exposures.
The etiology of most chronic diseases involves interactions between environmental factors and genes that modulate important physiological processes. This assumption is supported by the many complex diseases caused by reversible behaviors or avoidable exposures, and by the relatively rare number of diseases attributed to single gene mutations. Environmental factors are implicated in many common conditions such as asthma, cancer, diabetes, hypertension, immune deficiency disorders, and Parkinson’s disease. The molecular mechanisms underlying these correlations, however, are not well understood. CTD includes curated data describing cross-species chemical–gene/protein interactions and chemical– and gene–disease associations to illuminate molecular mechanisms underlying variable susceptibility and environmentally influenced diseases. These data will also provide insights into complex chemical–gene and protein interaction networks. Discover.
|
| Other Name(s): | CTD - Comparative Toxicogenomics Database |
| Parent Organization: | Resource:Mount Desert Island Biological Laboratory, North Carolina State University; North Carolina; USA |
| Supporting Agency: | National Institute of Environmental Health Sciences, National Center for Research Resources, Pfizer, American Chemistry Council |
| Related to: | Resource:Gene Ontology Tools, Resource:GO |
| Resource Type(s): | Database, Data analysis service |
| Keywords: | Environment, Chemical, Disease, Gene, Pathway, Protein, Interaction, Animal model, ontology or annotation browser |
| Grant: | ES014065, R01 ES019604, P20 RR016463 |
| Abbreviation: | CTD |
| Resource: | Resource |
| URL: | http://ctd.mdibl.org |
| PMID: | PMID 16902965, 16675512, 14735110, 12760826, |
| Availability: | Free for academic use |
| Id: | nif-0000-02683 |
| Organism: | Human, Mouse, Rat, Chicken, Zebrafish, Dog |
| Link to OWL / RDF: | Download this content as OWL/RDF |
Categories related to Resource:Comparative Toxicogenomics Database
Resource:DisGeNET, Resource:NIF Integrated Gene-Disease Interaction
Curation status: Uncurated
This resource will be curated within 7 days.
For Resource Owners:
After the resource is curated, you may create a sitemap, which will help keep your registry description up-to-date and inform search engines about your resource.
Note: For a new resource, the website's URL must first be verified by a NIF curator before you may proceed.
Learn more about what NIF can do for your resource.
Proudly proclaim your inclusion in NIF by displaying the "Registered with NIF" button on your site.
Please login to create the sitemap. (top right)
Notes
This page uses this default form:Resource
| Abbrev | CTD + |
| Availability | Free for academic use + |
| CurationStatus | curated + |
| DefiningCitation | http://ctd.mdibl.org + |
| Definition | The Comparative Toxicogenomics Database (C … The Comparative Toxicogenomics Database (CTD) is a public database that enhances understanding about the effects of environmental chemicals on human health. Integrated GO data and a GO browser add functionality to CTD by allowing users to understand biological functions, processes and cellular locations that are the targets of chemical exposures.
The etiology of most chronic diseases involves interactions between environmental factors and genes that modulate important physiological processes. This assumption is supported by the many complex diseases caused by reversible behaviors or avoidable exposures, and by the relatively rare number of diseases attributed to single gene mutations. Environmental factors are implicated in many common conditions such as asthma, cancer, diabetes, hypertension, immune deficiency disorders, and Parkinson’s disease. The molecular mechanisms underlying these correlations, however, are not well understood. CTD includes curated data describing cross-species chemical–gene/protein interactions and chemical– and gene–disease associations to illuminate molecular mechanisms underlying variable susceptibility and environmentally influenced diseases. These data will also provide insights into complex chemical–gene and protein interaction networks. Discover.
Platform: Online affected by a chemical? Platform: Online |
| ExampleImage |  + |
| Grant | Category:ES014065 +, Category:R01 ES019604 +, and Category:P20 RR016463 + |
| Has default formThis property is a special property in this wiki. | Resource + |
| Has role | Database +, and Data analysis service + |
| Id | nif-0000-02683 + |
| Is part of | Resource:Mount Desert Island Biological Laboratory +, and North Carolina State University; North Carolina; USA + |
| Keywords | Environment +, Chemical +, Disease +, Gene +, Pathway +, Protein +, Interaction +, Animal model +, and Ontology or annotation browser + |
| Label | Resource:Comparative Toxicogenomics Database + |
| ModifiedDate | 20 July 2012 + |
| PMID | 16902965, 16675512, 14735110, 12760826, + |
| Page has default formThis property is a special property in this wiki. | Resource + |
| RelatedTo | Resource:Gene Ontology Tools +, and Resource:GO + |
| Species | Human +, Mouse +, Rat +, Chicken +, Zebrafish +, and Dog + |
| SuperCategory | Resource + |
| Supporting Agency | National Institute of Environmental Health Sciences +, National Center for Research Resources +, Pfizer +, and American Chemistry Council + |
| Synonym | CTD - Comparative Toxicogenomics Database + |
