From NeuroLex
Resource:National Cell Repository for Alzheimers Disease
| Name: | Resource:National Cell Repository for Alzheimers Disease |
| Description: | The goal of the National Cell Repository for Alzheimer’s Disease (NCRAD) is to help researchers find genes that increase the risk for Alzheimer’s disease (AD) and dementia. To accomplish this goal, in 1990, NCRAD was funded by the National Institute on Aging (NIA) to provide researchers with the biological samples and data necessary for finding important genetic factors in AD and dementia. Understanding the causes of AD and dementia will likely lead to better treatments for this devastating disease.
The NIA is committed to determining the causes of AD so that more effective therapies can be developed to treat people with this devastating disorder. To help identify the genes that play a role in the development of AD, the NIA has funded NCRAD as a national resource where clinical information and biological material (DNA, plasma, serum, RNA and brain tissue) can be stored from individuals with AD as well as from individuals without any symptoms of memory loss or dementia. To help identify the genes contributing to the risk for AD, a number of different studies are currently ongoing. These include studies enrolling families with multiple members diagnosed with AD, as well as individuals without a strong family history of AD. NCRAD collects and maintains biological specimens and associated data on large numbers of genetically informative, phenotypically well-characterized families with multiple individuals affected with Alzheimer's disease, as well as individuals for case-control studies. Qualified research scientists may apply to NCRAD for samples and data to conduct genetic research. NIA has in place a Genetics Initiative to assist in the identification of the risk factor genes for Alzheimer's disease. To this end, NIA supports the National Cell Repository for Alzheimer's Disease (NCRAD) at Indiana University as a national repository in order to facilitate access by qualified investigators to samples and Associated Phenotypic Data for the study of the genetics of late-onset Alzheimer's disease. Therefore it is the policy of the NIA that useful specimens and Associated Phenotypic Data for the genetics of late-onset Alzheimer's disease be deposited at NCRAD whenever possible. Qualified investigators will be able to use biological samples and Associated Phenotypic Data supplied by NCRAD. Application for use will be made directly to NCRAD. Associated Phenotypic Data is defined as deidentified data on family structure, age, sex, vital status, psychopathology, diagnosis, and other clinically relevant associated phenotypic information, stripped of all personal identifiers and thus unlinkable to the individuals from whom they were obtained. To help identify the genes contributing to the risk for Alzheimer's disease, a number of different studies are currently ongoing. These include studies enrolling families with multiple members diagnosed with Alzheimer's disease as well as individuals without a strong family history of Alzheimer's disease. The NIA's national effort to help researchers identify the genes that play a role in the development of Alzheimer's disease, seeks to recruit 1,000 families with two or more living brothers or sisters who have been diagnosed with late onset Alzheimer's disease. Through the participation of these families, scientific researchers will be able to obtain the critical information they need to help them identify the genes that increase the risk for late onset Alzheimer's disease. The Alzheimer's Association is working with the National Institute on Aging and study sites across the country to help refer families for this important study. |
| Parent Organization: | Indiana University; Indiana; USA, US Biobank |
| Supporting Agency: | NIA |
| Related to: | Human |
| Resource Type(s): | Tissue bank, Data storage repository, Biomaterial supply resource |
| Keywords: | genes, genetic research, Alzheimer's disease, clinical, control, dementia, DNA, late onset alzheimer's disease, memory loss, normal, phenotypic data, research study |
| Abbreviation: | NCRAD |
| Resource: | Resource |
| URL: | http://ncrad.iu.edu/ |
| Id: | nif-0000-00178 |
| Link to OWL / RDF: | Download this content as OWL/RDF |
Categories related to Resource:National Cell Repository for Alzheimers Disease
Curation status: Curated
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This page uses this default form:Resource
| Abbrev | NCRAD + |
| CurationStatus | curated + |
| DefiningCitation | http://ncrad.iu.edu/ + |
| Definition | The goal of the National Cell Repository f … The goal of the National Cell Repository for Alzheimer’s Disease (NCRAD) is to help researchers find genes that increase the risk for Alzheimer’s disease (AD) and dementia. To accomplish this goal, in 1990, NCRAD was funded by the National Institute on Aging (NIA) to provide researchers with the biological samples and data necessary for finding important genetic factors in AD and dementia. Understanding the causes of AD and dementia will likely lead to better treatments for this devastating disease.
The NIA is committed to determining the causes of AD so that more effective therapies can be developed to treat people with this devastating disorder. To help identify the genes that play a role in the development of AD, the NIA has funded NCRAD as a national resource where clinical information and biological material (DNA, plasma, serum, RNA and brain tissue) can be stored from individuals with AD as well as from individuals without any symptoms of memory loss or dementia. To help identify the genes contributing to the risk for AD, a number of different studies are currently ongoing. These include studies enrolling families with multiple members diagnosed with AD, as well as individuals without a strong family history of AD. NCRAD collects and maintains biological specimens and associated data on large numbers of genetically informative, phenotypically well-characterized families with multiple individuals affected with Alzheimer's disease, as well as individuals for case-control studies. Qualified research scientists may apply to NCRAD for samples and data to conduct genetic research. NIA has in place a Genetics Initiative to assist in the identification of the risk factor genes for Alzheimer's disease. To this end, NIA supports the National Cell Repository for Alzheimer's Disease (NCRAD) at Indiana University as a national repository in order to facilitate access by qualified investigators to samples and Associated Phenotypic Data for the study of the genetics of late-onset Alzheimer's disease. Therefore it is the policy of the NIA that useful specimens and Associated Phenotypic Data for the genetics of late-onset Alzheimer's disease be deposited at NCRAD whenever possible. Qualified investigators will be able to use biological samples and Associated Phenotypic Data supplied by NCRAD. Application for use will be made directly to NCRAD. Associated Phenotypic Data is defined as deidentified data on family structure, age, sex, vital status, psychopathology, diagnosis, and other clinically relevant associated phenotypic information, stripped of all personal identifiers and thus unlinkable to the individuals from whom they were obtained. To help identify the genes contributing to the risk for Alzheimer's disease, a number of different studies are currently ongoing. These include studies enrolling families with multiple members diagnosed with Alzheimer's disease as well as individuals without a strong family history of Alzheimer's disease. The NIA's national effort to help researchers identify the genes that play a role in the development of Alzheimer's disease, seeks to recruit 1,000 families with two or more living brothers or sisters who have been diagnosed with late onset Alzheimer's disease. Through the participation of these families, scientific researchers will be able to obtain the critical information they need to help them identify the genes that increase the risk for late onset Alzheimer's disease. The Alzheimer's Association is working with the National Institute on Aging and study sites across the country to help refer families for this important study. p refer families for this important study. |
| ExampleImage | |
| Has default formThis property is a special property in this wiki. | Resource + |
| Has role | Tissue bank +, Data storage repository +, and Biomaterial supply resource + |
| Id | nif-0000-00178 + |
| Is part of | Indiana University; Indiana; USA +, and US Biobank + |
| Keywords | Genes +, Genetic research +, Alzheimer's disease +, Clinical +, Control +, Dementia +, DNA +, Late onset alzheimer's disease +, Memory loss +, Normal +, Phenotypic data +, and Research study + |
| Label | Resource:National Cell Repository for Alzheimers Disease + |
| ModifiedDate | 19 March 2012 + |
| Page has default formThis property is a special property in this wiki. | Resource + |
| RelatedTo | Human + |
| SuperCategory | Resource + |
| Supporting Agency | NIA + |




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