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Category:A53T Alpha-Synuclein Drosophila
Authors Robert Bussel Jr. and David Eliezer  +
CurationStatus uncurated  +
Definition These mutant flies express a the human mut These mutant flies express a the human mutant A53T alpha-synuclein mutation. This mutation alters the secondary shift of residue 53 from a positive to a negative value and thereby creates a short contiguous region of negative shifts around the site of the mutation, indicating a local preference for extended backbone configurations. This mutation accelerates alpha-synuclein oligomerization, increases the rate of mature fibril formations, and aggregates much faster than wild type alpha-synuclein. It has an earlier onset. Flies expressing A53T alpha-synuclein show symptoms of Parkinson's disease and are used in the lab to study the disease. are used in the lab to study the disease.
Figure 1 +, 2 +, 3 +
Id nlx_organ_090703  +
JournalNumber 49 +
JournalVolume 276 +
Label A53T Alpha-Synuclein Drosophila  +
Modification dateThis property is a special property in this wiki. 28 October 2009 01:13:35  +
ModifiedDate 28 October 2009  +
PMID 11590151  +
Pages 45996-46003
PublicationDate 12/07/01 +
PublicationName The Journal of Biological Chemistry +
Title Residual Structure and Dynamics in Parkinson's Disease-associated Mutants of Alpha-Synuclein  +
Categories Mutant Drosophila
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