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Pedunculopontine tegmental nucleus

Name: Pedunculopontine tegmental nucleus
Description: A cell group originally defined by Jacobsohn in 1909 in humans, consisting of large, darkly staining neurons adjacent to the superior cerebellar peduncle at the midbrain-pontine junction. In 1983, Armstrong et al. recognized that these neurons in rats are cholinergic, and closely related to a second cluster of cholinergic cells in the adjacent laterodorsal tegmental nucleus. In 1987, Rye et al. defined this cell group in rats, gave references to the earlier literature, and demonstrated that it is NOT the target of the descending pallidal projection, but rather next to a region, the Midbrain Extrapyramidal Area (MEA) that does receive this input. Some modern definitions include many non-cholinergic cells that are interspersed among the cholinergic neurons within the "PPT," but those other cell groups often extend beyond the borders of the cholinergic one, have never been characterized, and many are probably unrelated to it (or have quite different functions). Hence, for this definition, we are restricting the use to the cholinergic cell group, which was originally given this name by Jacobsohn.
Is part of: midbrain reticular formation
Abbreviation: PPTg, PPT, PPTg, PPN
Super-category: Regional part of brain
URL: Rye DB, Saper CB, Lee HJ, Wainer BH. Pedunculopontine tegmental nucleus of the rat: cytoarchitecture, cytochemistry, and some extrapyramidal connections of the mesopontine tegmentum. J Comp Neurol 259:483-428, 1987
Id: birnlex_1437
Defining criteria: cyto-architecture
Organism: Rat, Human, Macaca
Link to OWL / RDF: Download this content as OWL/RDF
Neuronames ID ( what's this?): 495
Defining Criteria: cyto-architecture
Profile: expression
Atlas Coordinates: Paxinos and Watson 1998 rat: AP -7.8, DV -7.4, RL 1.8
Brain regions that send axons into this region: Thalamus, Brainstem

Inferred outgoing projections for Pedunculopontine tegmental nucleus

The following brain regions receive axons from Pedunculopontine tegmental nucleus: Nucleus prepositus, Subthalamic nucleus. The statements about these projections are not made on this page, but rather are made on the pages linked here.

Inferred incoming projections for Pedunculopontine tegmental nucleus

The following brain regions send axons into Pedunculopontine tegmental nucleus: Nucleus prepositus. The statements about these projections are not made on this page, but rather are made on the pages linked here.




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Facts about Pedunculopontine tegmental nucleusRDF feed
AbbrevPPTg, PPT, PPTg, PPN  +
AbbrevSourcehttp://purl.org/nbirn/birnlex/ontology/annotation/BIRNLex_annotation_properties.owl#NeuroNames_abbrevSource  +, and http://ontology.neuinfo.org/NIF/Backend/BIRNLex_annotation_properties.owl#NeuroNames_abbrevSource  +
AfferentProjectionsThalamus  +, and Brainstem  +
CommentThese cell groups target a region just med These cell groups target a region just medial to the PPT, Shown in most major textbooks, From the internal segment of the globus pallidus and the substantia nigra pars reticulata, Which Rye et al. have called the midbrain extrapyramidal area (MEA). The actual inputs to the PPT neurons are largely unknown., In fact DOES NOT EXIST (!). Instead, The most widely cited afferent input to the PPT ost widely cited afferent input to the PPT
CoordinatesPaxinos and Watson 1998 rat: AP -7.8, DV -7.4, RL 1.8  +
Created15 July 2006  +
CurationStatusuncurated  +
CuratorBill Bug  +
DefiningCitationRye DB, Saper CB, Lee HJ, Wainer BH. Pedunculopontine tegmental nucleus of the rat: cytoarchitecture, cytochemistry, and some extrapyramidal connections of the mesopontine tegmentum. J Comp Neurol 259:483-428, 1987  +
DefiningCriteriacyto-architecture  +
DefinitionA cell group originally defined by Jacobso A cell group originally defined by Jacobsohn in 1909 in humans, consisting of large, darkly staining neurons adjacent to the superior cerebellar peduncle at the midbrain-pontine junction. In 1983, Armstrong et al. recognized that these neurons in rats are cholinergic, and closely related to a second cluster of cholinergic cells in the adjacent laterodorsal tegmental nucleus. In 1987, Rye et al. defined this cell group in rats, gave references to the earlier literature, and demonstrated that it is NOT the target of the descending pallidal projection, but rather next to a region, the Midbrain Extrapyramidal Area (MEA) that does receive this input. Some modern definitions include many non-cholinergic cells that are interspersed among the cholinergic neurons within the "PPT," but those other cell groups often extend beyond the borders of the cholinergic one, have never been characterized, and many are probably unrelated to it (or have quite different functions). Hence, for this definition, we are restricting the use to the cholinergic cell group, which was originally given this name by Jacobsohn. s originally given this name by Jacobsohn.
Has default formThis property is a special property in this wiki.PONS brain region  +
Idbirnlex_1437  +
Is part ofMidbrain reticular formation  +
LabelPedunculopontine tegmental nucleus  +
ModifiedDate3 October 2011  +
NeuronamesLinkhttp://braininfo.rprc.washington.edu/Scripts/hiercentraldirectory.aspx?ID=495  +
Profileexpression  +
SpeciesRat  +, Human  +, and Macaca  +
SuperCategoryRegional part of brain  +
UmlscuiC0262306  +