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1-120 Truncated Alpha-Synuclein Drosophila

Name: 1-120 Truncated Alpha-Synuclein Drosophila
Description: This transgenic drosophila expresses a form of alpha-synuclein that is a C-terminally truncated fragment comprising amino acids 1-120. This form of alpha-synuclein has an enhanced ability to aggregate and thus enhanced neurotoxicity. This mutant is used in research to determine the role of alpha-synuclein aggregation in neurodegenerative diseases, such as Parkinsons.
Id: nlx_organ_090801
PMID: PMID 17376994
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Contributors

Laurenthompson214, Mimam



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AuthorsMagali Periquet  +, Tudor Fulga  +, Liisa Myllykangas  +, Michael G. Schlossmacher  +, and and Mel B. Feany  +
CurationStatusuncurated  +
DefinitionThis transgenic drosophila expresses a for This transgenic drosophila expresses a form of alpha-synuclein that is a C-terminally truncated fragment comprising amino acids 1-120. This form of alpha-synuclein has an enhanced ability to aggregate and thus enhanced neurotoxicity. This mutant is used in research to determine the role of alpha-synuclein aggregation in neurodegenerative diseases, such as Parkinsons. degenerative diseases, such as Parkinsons.
Figure1-3  +
Idnlx_organ_090801  +
JournalNumber12  +
JournalVolume27  +
Label1-120 Truncated Alpha-Synuclein Drosophila  +
ModifiedDate28 October 2009  +
PMID17376994  +
Pages3338-3346
PublicationDateMarch 21  +, and 2007  +
PublicationNameThe Journal of Neuroscience  +
TitleAggregated Alpha-Synuclein Mediates Dopaminergic Neurotoxicity In Vivo  +