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A53T Alpha-Synuclein Drosophila

Name: A53T Alpha-Synuclein Drosophila
Description: These mutant flies express a the human mutant A53T alpha-synuclein mutation. This mutation alters the secondary shift of residue 53 from a positive to a negative value and thereby creates a short contiguous region of negative shifts around the site of the mutation, indicating a local preference for extended backbone configurations. This mutation accelerates alpha-synuclein oligomerization, increases the rate of mature fibril formations, and aggregates much faster than wild type alpha-synuclein. It has an earlier onset. Flies expressing A53T alpha-synuclein show symptoms of Parkinson's disease and are used in the lab to study the disease.
Id: nlx_organ_090703
PMID: PMID 11590151
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Contributors

Laurenthompson214, Mimam



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Facts about A53T Alpha-Synuclein DrosophilaRDF feed
AuthorsRobert Bussel Jr. and David Eliezer  +
CurationStatusuncurated  +
DefinitionThese mutant flies express a the human mut These mutant flies express a the human mutant A53T alpha-synuclein mutation. This mutation alters the secondary shift of residue 53 from a positive to a negative value and thereby creates a short contiguous region of negative shifts around the site of the mutation, indicating a local preference for extended backbone configurations. This mutation accelerates alpha-synuclein oligomerization, increases the rate of mature fibril formations, and aggregates much faster than wild type alpha-synuclein. It has an earlier onset. Flies expressing A53T alpha-synuclein show symptoms of Parkinson's disease and are used in the lab to study the disease. are used in the lab to study the disease.
Figure1  +, 2  +, and 3  +
Idnlx_organ_090703  +
JournalNumber49  +
JournalVolume276  +
LabelA53T Alpha-Synuclein Drosophila  +
ModifiedDate28 October 2009  +
PMID11590151  +
Pages45996-46003
PublicationDate12/07/01  +
PublicationNameThe Journal of Biological Chemistry  +
TitleResidual Structure and Dynamics in Parkinson's Disease-associated Mutants of Alpha-Synuclein  +