arrow

From NeuroLex

Jump to: navigation, search

[[Category:]]


A53T Alpha-Synuclein Drosophila

Name: A53T Alpha-Synuclein Drosophila
Description: These mutant flies express a the human mutant A53T alpha-synuclein mutation. This mutation alters the secondary shift of residue 53 from a positive to a negative value and thereby creates a short contiguous region of negative shifts around the site of the mutation, indicating a local preference for extended backbone configurations. This mutation accelerates alpha-synuclein oligomerization, increases the rate of mature fibril formations, and aggregates much faster than wild type alpha-synuclein. It has an earlier onset. Flies expressing A53T alpha-synuclein show symptoms of Parkinson's disease and are used in the lab to study the disease.
*Id: nlx_organ_090703
PMID: PMID 11590151
Link to OWL / RDF: Download this content as OWL/RDF


Contributors

Laurenthompson214, Mimam



bookmark

*Note: Neurolex imports many terms and their ids from existing community ontologies, e.g., the Gene Ontology. Neurolex, however, is a dynamic site and any content beyond the identifier should not be presumed to reflect the content or views of the source ontology. Users should consult with the authoritative source for each ontology for current information.

Facts about A53T Alpha-Synuclein DrosophilaRDF feed
AuthorsRobert Bussel Jr. and David Eliezer  +
CurationStatusuncurated  +
DefinitionThese mutant flies express a the human mut These mutant flies express a the human mutant A53T alpha-synuclein mutation. This mutation alters the secondary shift of residue 53 from a positive to a negative value and thereby creates a short contiguous region of negative shifts around the site of the mutation, indicating a local preference for extended backbone configurations. This mutation accelerates alpha-synuclein oligomerization, increases the rate of mature fibril formations, and aggregates much faster than wild type alpha-synuclein. It has an earlier onset. Flies expressing A53T alpha-synuclein show symptoms of Parkinson's disease and are used in the lab to study the disease. are used in the lab to study the disease.
Figure1  +, 2  +, and 3  +
Idnlx_organ_090703  +
JournalNumber49  +
JournalVolume276  +
LabelA53T Alpha-Synuclein Drosophila  +
ModifiedDate28 October 2009  +
PMID11590151  +
Pages45996-46003
PublicationDate12/07/01  +
PublicationNameThe Journal of Biological Chemistry  +
TitleResidual Structure and Dynamics in Parkinson's Disease-associated Mutants of Alpha-Synuclein  +