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A53T Alpha-Synuclein Drosophila
| Name: | A53T Alpha-Synuclein Drosophila |
| Description: | These mutant flies express a the human mutant A53T alpha-synuclein mutation. This mutation alters the secondary shift of residue 53 from a positive to a negative value and thereby creates a short contiguous region of negative shifts around the site of the mutation, indicating a local preference for extended backbone configurations. This mutation accelerates alpha-synuclein oligomerization, increases the rate of mature fibril formations, and aggregates much faster than wild type alpha-synuclein. It has an earlier onset. Flies expressing A53T alpha-synuclein show symptoms of Parkinson's disease and are used in the lab to study the disease. |
| PMID: | PMID 11590151 |
| Id: | nlx_organ_090703 |
| Link to OWL / RDF: | Download this content as OWL/RDF |
Facts about A53T Alpha-Synuclein DrosophilaRDF feed
| Authors | Robert Bussel Jr. and David Eliezer + |
| CurationStatus | uncurated + |
| Definition | These mutant flies express a the human mut … These mutant flies express a the human mutant A53T alpha-synuclein mutation. This mutation alters the secondary shift of residue 53 from a positive to a negative value and thereby creates a short contiguous region of negative shifts around the site of the mutation, indicating a local preference for extended backbone configurations. This mutation accelerates alpha-synuclein oligomerization, increases the rate of mature fibril formations, and aggregates much faster than wild type alpha-synuclein. It has an earlier onset. Flies expressing A53T alpha-synuclein show symptoms of Parkinson's disease and are used in the lab to study the disease. are used in the lab to study the disease. |
| Figure | 1 +, 2 +, and 3 + |
| Id | nlx_organ_090703 + |
| JournalNumber | 49 + |
| JournalVolume | 276 + |
| Label | A53T Alpha-Synuclein Drosophila + |
| ModifiedDate | 28 October 2009 + |
| PMID | 11590151 + |
| Pages | 45996-46003 |
| PublicationDate | 12/07/01 + |
| PublicationName | The Journal of Biological Chemistry + |
| Title | Residual Structure and Dynamics in Parkinson's Disease-associated Mutants of Alpha-Synuclein + |