arrow

From NeuroLex

Jump to: navigation, search



Abacavir

Name: Abacavir
Description: Abacavir (ABC) is the most powerful nucleoside analog reverse transcriptase inhibitor (NRTI) used to treat HIV and AIDS. (Wikipedia) Pharmacology: Abacavir is a nucleoside reverse transcriptase inhibitor (NRTI) with activity against Human Immunodeficiency Virus Type 1 (HIV-1). Abacavir is phosphorylated to active metabolites that compete for incorporation into viral DNA. They inhibit the HIV reverse transcriptase enzyme competitively and act as a chain terminator of DNA synthesis. The lack of a 3'-OH group in the incorporated nucleoside analogue prevents the formation of the 5' to 3' phosphodiester linkage essential for DNA chain elongation, and therefore, the viral DNA growth is terminated. Mechanism of action: Abacavir is a carbocyclic synthetic nucleoside analogue. Intracellularly, abacavir is converted by cellular enzymes to the active metabolite carbovir triphosphate, an analogue of deoxyguanosine-5'-triphosphate (dGTP). Carbovir triphosphate inhibits the activity of HIV-1 reverse transcriptase (RT) both by competing with the natural substrate dGTP and by its incorporation into viral DNA. Drug type: Approved. Investigational. Small Molecule. Drug category: Anti-HIV Agents. Nucleoside and Nucleotide Reverse Transcriptase Inhibitors. Reverse Transcriptase Inhibitors
Synonym(s): ABC, abacavir, Epzicom, Ziagen
Related to: Gag-Pol polyprotein
Has role: Drug
Super-category: Molecular entity
URL: http://www.drugbank.ca/drugs/DB01048
Id: CHEBI_2360
Link to OWL / RDF: Download this content as OWL/RDF




bookmark
Facts about AbacavirRDF feed
Commenttaken from DrugBank
CurationStatusuncurated  +
CuratorAb  +
DefiningCitationhttp://www.drugbank.ca/drugs/DB01048  +
DefinitionAbacavir (ABC) is the most powerful nucleo Abacavir (ABC) is the most powerful nucleoside analog reverse transcriptase inhibitor (NRTI) used to treat HIV and AIDS. (Wikipedia) Pharmacology: Abacavir is a nucleoside reverse transcriptase inhibitor (NRTI) with activity against Human Immunodeficiency Virus Type 1 (HIV-1). Abacavir is phosphorylated to active metabolites that compete for incorporation into viral DNA. They inhibit the HIV reverse transcriptase enzyme competitively and act as a chain terminator of DNA synthesis. The lack of a 3'-OH group in the incorporated nucleoside analogue prevents the formation of the 5' to 3' phosphodiester linkage essential for DNA chain elongation, and therefore, the viral DNA growth is terminated. Mechanism of action: Abacavir is a carbocyclic synthetic nucleoside analogue. Intracellularly, abacavir is converted by cellular enzymes to the active metabolite carbovir triphosphate, an analogue of deoxyguanosine-5'-triphosphate (dGTP). Carbovir triphosphate inhibits the activity of HIV-1 reverse transcriptase (RT) both by competing with the natural substrate dGTP and by its incorporation into viral DNA. Drug type: Approved. Investigational. Small Molecule. Drug category: Anti-HIV Agents. Nucleoside and Nucleotide Reverse Transcriptase Inhibitors. Reverse Transcriptase Inhibitors hibitors. Reverse Transcriptase Inhibitors
Has roleDrug  +
IdCHEBI_2360  +
LabelAbacavir  +
ModifiedDate14 April 2014  +
RelatedToGag-Pol polyprotein  +
SuperCategoryMolecular entity  +
SynonymABC  +, abacavir  +, Epzicom  +, and Ziagen  +