EditFrom NeuroLex
Acebutolol
| Name: | Acebutolol |
| Description: | A cardioselective beta-adrenergic antagonist with little effect on the bronchial receptors. The drug has stabilizing and quinidine-like effects on cardiac rhythm as well as weak inherent sympathomimetic action. (PubChem) Pharmacology: Acebutolol is a cardioselective, beta-adrenoreceptor blocking agent, which possesses mild intrinsic sympathomimetic activity (ISA) in its therapeutically effective dose range. In general, beta-blockers reduce the work the heart has to do and allow it to beat more regularly. Acebutolol has less antagonistic effects on peripheral vascular 2-receptors at rest and after epinephrine stimulation than nonselective beta-antagonists. Low doses of acebutolol produce less evidence of bronchoconstriction than nonselective agents like propranolol but more than atenolol. Mechanism of action: Acebutolol is a selective 1-receptor antagonist. Activation of 1-receptors by epinephrine increases the heart rate and the blood pressure, and the heart consumes more oxygen. Acebutolol blocks these receptors which reverses the effects of epinephrine, lowering the heart rate and blood pressure. In addition, beta blockers prevent the release of renin, which is a hormone produced by the kidneys which leads to constriction of blood vessels. Drug type: Approved. Small Molecule. Drug category: Adrenergic beta-Antagonists. Anti-Arrhythmia Agents. Antihypertensive Agents |
| Synonym(s): | Acebutolol HCL, Acebutololo, Acetobutolol, dl-Acebutolol, Monitan, Neptal, Prent, Sectral |
| Related to: | Beta-1 adrenergic receptor |
| Has role: | Drug |
| Super-category: | Molecule |
| URL: | http://www.drugbank.ca/drugs/DB01193 |
| Id: | CHEBI_2379 |
| Link to OWL / RDF: | Download this content as OWL/RDF |
Facts about AcebutololRDF feed
| Comment | taken from DrugBank |
| CurationStatus | uncurated + |
| Curator | Ab + |
| DefiningCitation | http://www.drugbank.ca/drugs/DB01193 + |
| Definition | A cardioselective beta-adrenergic antagoni … A cardioselective beta-adrenergic antagonist with little effect on the bronchial receptors. The drug has stabilizing and quinidine-like effects on cardiac rhythm as well as weak inherent sympathomimetic action. (PubChem) Pharmacology: Acebutolol is a cardioselective, beta-adrenoreceptor blocking agent, which possesses mild intrinsic sympathomimetic activity (ISA) in its therapeutically effective dose range. In general, beta-blockers reduce the work the heart has to do and allow it to beat more regularly. Acebutolol has less antagonistic effects on peripheral vascular 2-receptors at rest and after epinephrine stimulation than nonselective beta-antagonists. Low doses of acebutolol produce less evidence of bronchoconstriction than nonselective agents like propranolol but more than atenolol. Mechanism of action: Acebutolol is a selective 1-receptor antagonist. Activation of 1-receptors by epinephrine increases the heart rate and the blood pressure, and the heart consumes more oxygen. Acebutolol blocks these receptors which reverses the effects of epinephrine, lowering the heart rate and blood pressure. In addition, beta blockers prevent the release of renin, which is a hormone produced by the kidneys which leads to constriction of blood vessels. Drug type: Approved. Small Molecule. Drug category: Adrenergic beta-Antagonists. Anti-Arrhythmia Agents. Antihypertensive Agents Arrhythmia Agents. Antihypertensive Agents |
| Has role | Drug + |
| Id | CHEBI_2379 + |
| Label | Acebutolol + |
| ModifiedDate | 16 November 2010 + |
| RelatedTo | Beta-1 adrenergic receptor + |
| SuperCategory | Molecule + |
| Synonym | Acebutolol HCL +, Acebutololo +, Acetobutolol +, dl-Acebutolol +, Monitan +, Neptal +, Prent +, and Sectral + |