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Acebutolol

Name: Acebutolol
Description: A cardioselective beta-adrenergic antagonist with little effect on the bronchial receptors. The drug has stabilizing and quinidine-like effects on cardiac rhythm as well as weak inherent sympathomimetic action. (PubChem) Pharmacology: Acebutolol is a cardioselective, beta-adrenoreceptor blocking agent, which possesses mild intrinsic sympathomimetic activity (ISA) in its therapeutically effective dose range. In general, beta-blockers reduce the work the heart has to do and allow it to beat more regularly. Acebutolol has less antagonistic effects on peripheral vascular 2-receptors at rest and after epinephrine stimulation than nonselective beta-antagonists. Low doses of acebutolol produce less evidence of bronchoconstriction than nonselective agents like propranolol but more than atenolol. Mechanism of action: Acebutolol is a selective 1-receptor antagonist. Activation of 1-receptors by epinephrine increases the heart rate and the blood pressure, and the heart consumes more oxygen. Acebutolol blocks these receptors which reverses the effects of epinephrine, lowering the heart rate and blood pressure. In addition, beta blockers prevent the release of renin, which is a hormone produced by the kidneys which leads to constriction of blood vessels. Drug type: Approved. Small Molecule. Drug category: Adrenergic beta-Antagonists. Anti-Arrhythmia Agents. Antihypertensive Agents
Synonym(s): Acebutolol HCL, Acebutololo, Acetobutolol, dl-Acebutolol, Monitan, Neptal, Prent, Sectral
Has role: Drug
Super-category: Molecular entity
URL: http://www.drugbank.ca/drugs/DB01193
Id: CHEBI_2379
Related to: Beta-1 adrenergic receptor
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Commenttaken from DrugBank
CurationStatusuncurated  +
CuratorAb  +
DefiningCitationhttp://www.drugbank.ca/drugs/DB01193  +
DefinitionA cardioselective beta-adrenergic antagoni A cardioselective beta-adrenergic antagonist with little effect on the bronchial receptors. The drug has stabilizing and quinidine-like effects on cardiac rhythm as well as weak inherent sympathomimetic action. (PubChem) Pharmacology: Acebutolol is a cardioselective, beta-adrenoreceptor blocking agent, which possesses mild intrinsic sympathomimetic activity (ISA) in its therapeutically effective dose range. In general, beta-blockers reduce the work the heart has to do and allow it to beat more regularly. Acebutolol has less antagonistic effects on peripheral vascular 2-receptors at rest and after epinephrine stimulation than nonselective beta-antagonists. Low doses of acebutolol produce less evidence of bronchoconstriction than nonselective agents like propranolol but more than atenolol. Mechanism of action: Acebutolol is a selective 1-receptor antagonist. Activation of 1-receptors by epinephrine increases the heart rate and the blood pressure, and the heart consumes more oxygen. Acebutolol blocks these receptors which reverses the effects of epinephrine, lowering the heart rate and blood pressure. In addition, beta blockers prevent the release of renin, which is a hormone produced by the kidneys which leads to constriction of blood vessels. Drug type: Approved. Small Molecule. Drug category: Adrenergic beta-Antagonists. Anti-Arrhythmia Agents. Antihypertensive Agents Arrhythmia Agents. Antihypertensive Agents
Has roleDrug  +
IdCHEBI_2379  +
LabelAcebutolol  +
ModifiedDate14 April 2014  +
RelatedToBeta-1 adrenergic receptor  +
SuperCategoryMolecular entity  +
SynonymAcebutolol HCL  +, Acebutololo  +, Acetobutolol  +, dl-Acebutolol  +, Monitan  +, Neptal  +, Prent  +, and Sectral  +