arrow

From NeuroLex

Jump to: navigation, search



Acenocoumarol

Name: Acenocoumarol
Description: A coumarin that is used as an anticoagulant. Its actions and uses are similar to those of warfarin. (From Martindale, The Extra Pharmacopoeia, 30th ed, p233) Pharmacology: Acenocoumarol is a coumarin that is used as an anticoagulant. Its actions and uses are similar to those of warfarin. (From Martindale, The Extra Pharmacopoeia, 30th ed, p233) Mechanism of action: Acenocoumarol inhibits vitamin K reductase, resulting in depletion of the reduced form of vitamin K (vitamin KH2). As vitamin K is a cofactor for the carboxylation of glutamate residues on the N-terminal regions of vitamin K-dependent proteins, this limits the gamma-carboxylation and subsequent activation of the vitamin K-dependent coagulant proteins. The synthesis of vitamin K-dependent coagulation factors II, VII, IX, and X and anticoagulant proteins C and S is inhibited. Depression of three of the four vitamin K-dependent coagulation factors (factors II, VII, and X) results in decresed prothrombin levels and a decrease in the amount of thrombin generated and bound to fibrin. This reduces the thrombogenicity of clots. Drug type: Approved. Small Molecule. Drug category: Anticoagulants. Coumarin and Indandione Derivatives
Synonym(s): Acenocoumarin, Acenocoumarolum (inn-latin), Nicoumalone, Nicumalon, Nitrophenylacetylethyl-4-hydroxycoumarine, Nitrovarfarian, Nitrowarfarin, Ascumar, Neositron, Sincoumar, Sinkumar, Sinthrom, Sinthrome, Sintrom, Syncoumar, Syncumar, Syntrom, Zotil
Related to: Serum albumin, Vitamin K epoxide reductase complex subunit 1, Alpha-1-acid glycoprotein 1
Has role: Drug
Super-category: Molecular entity
URL: http://www.drugbank.ca/drugs/DB01418
Id: DB01418
Link to OWL / RDF: Download this content as OWL/RDF


Contributors

Ccdbuser, Nifbot2

Pages in category "Acenocoumarol"

The following 13 pages are in this category, out of 13 total.

N

N cont.

N cont.



bookmark
Facts about AcenocoumarolRDF feed
Commenttaken from DrugBank
CuratorAb  +
DefiningCitationhttp://www.drugbank.ca/drugs/DB01418  +
DefinitionA coumarin that is used as an anticoagulan A coumarin that is used as an anticoagulant. Its actions and uses are similar to those of warfarin. (From Martindale, The Extra Pharmacopoeia, 30th ed, p233) Pharmacology: Acenocoumarol is a coumarin that is used as an anticoagulant. Its actions and uses are similar to those of warfarin. (From Martindale, The Extra Pharmacopoeia, 30th ed, p233) Mechanism of action: Acenocoumarol inhibits vitamin K reductase, resulting in depletion of the reduced form of vitamin K (vitamin KH2). As vitamin K is a cofactor for the carboxylation of glutamate residues on the N-terminal regions of vitamin K-dependent proteins, this limits the gamma-carboxylation and subsequent activation of the vitamin K-dependent coagulant proteins. The synthesis of vitamin K-dependent coagulation factors II, VII, IX, and X and anticoagulant proteins C and S is inhibited. Depression of three of the four vitamin K-dependent coagulation factors (factors II, VII, and X) results in decresed prothrombin levels and a decrease in the amount of thrombin generated and bound to fibrin. This reduces the thrombogenicity of clots. Drug type: Approved. Small Molecule. Drug category: Anticoagulants. Coumarin and Indandione Derivatives lants. Coumarin and Indandione Derivatives
Has roleDrug  +
IdDB01418  +
LabelAcenocoumarol  +
ModifiedDate14 April 2014  +
RelatedToSerum albumin  +, Vitamin K epoxide reductase complex subunit 1  +, and Alpha-1-acid glycoprotein 1  +
SuperCategoryMolecular entity  +
SynonymAcenocoumarin  +, Acenocoumarolum (inn-latin)  +, Nicoumalone  +, Nicumalon  +, Nitrophenylacetylethyl-4-hydroxycoumarine  +, Nitrovarfarian  +, Nitrowarfarin  +, Ascumar  +, Neositron  +, Sincoumar  +, Sinkumar  +, Sinthrom  +, Sinthrome  +, Sintrom  +, Syncoumar  +, Syncumar  +, Syntrom  +, and Zotil  +