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Acetohydroxamic Acid

Name: Acetohydroxamic Acid
Description: Acetohydroxamic Acid, a synthetic drug derived from hydroxylamine and ethyl acetate, is similar in structure to urea. In the urine, it acts as an antagonist of the bacterial enzyme urease. Acetohydroxamic Acid has no direct antimicrobial action and does not acidify urine directly. It is used, in addition to antibiotics or medical procedures, to treat chronic urea-splitting urinary infections. Pharmacology: Acetohydroxamic Acid, a synthetic drug derived from hydroxylamine and ethyl acetate, is similar in structure to urea. In the urine, it acts as an antagonist of the bacterial enzyme urease. Acetohydroxamic Acid has no direct antimicrobial action and does not acidify urine directly. Mechanism of action: Acetohydroxamic Acid reversibly inhibits the bacterial enzyme urease. This inhibits the hydrolysis of urea and production of ammonia in urine infected with urea-splitting organisms, leading to a decrease in pH and ammonia levels. As antimicrobial agents are more effective in such conditions, the effectiveness of these agents is amplified, resulting in a higher cure rate. Drug type: Approved. Small Molecule. Drug category: Enzyme Inhibitors
Synonym(s): AHA, Acethydroxamsaure, Acetic acid, oxime, Acetohydroxamate, Acetohydroximic acid, Acetyl hydroxyamino, Acetylhydroxamic acid, Cetohyroxamic acid, Methylhydroxamic acid, N-Hydroxyacetamide, Lithostat
Has role: Drug
Super-category: Molecular entity
URL: http://www.drugbank.ca/drugs/DB00551
*Id: CHEBI:27777
Related to: Urease alpha subunit, Macrophage metalloelastase
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Facts about Acetohydroxamic AcidRDF feed
Commenttaken from DrugBank
CurationStatusuncurated  +
CuratorAb  +
DefiningCitationhttp://www.drugbank.ca/drugs/DB00551  +
DefinitionAcetohydroxamic Acid, a synthetic drug der Acetohydroxamic Acid, a synthetic drug derived from hydroxylamine and ethyl acetate, is similar in structure to urea. In the urine, it acts as an antagonist of the bacterial enzyme urease. Acetohydroxamic Acid has no direct antimicrobial action and does not acidify urine directly. It is used, in addition to antibiotics or medical procedures, to treat chronic urea-splitting urinary infections. Pharmacology: Acetohydroxamic Acid, a synthetic drug derived from hydroxylamine and ethyl acetate, is similar in structure to urea. In the urine, it acts as an antagonist of the bacterial enzyme urease. Acetohydroxamic Acid has no direct antimicrobial action and does not acidify urine directly. Mechanism of action: Acetohydroxamic Acid reversibly inhibits the bacterial enzyme urease. This inhibits the hydrolysis of urea and production of ammonia in urine infected with urea-splitting organisms, leading to a decrease in pH and ammonia levels. As antimicrobial agents are more effective in such conditions, the effectiveness of these agents is amplified, resulting in a higher cure rate. Drug type: Approved. Small Molecule. Drug category: Enzyme Inhibitors Molecule. Drug category: Enzyme Inhibitors
Has roleDrug  +
IdCHEBI:27777  +
LabelAcetohydroxamic Acid  +
ModifiedDate12 August 2014  +
RelatedToUrease alpha subunit  +, and Macrophage metalloelastase  +
SuperCategoryMolecular entity  +
SynonymAHA  +, Acethydroxamsaure  +, Acetic acid  +, oxime  +, Acetohydroxamate  +, Acetohydroximic acid  +, Acetyl hydroxyamino  +, Acetylhydroxamic acid  +, Cetohyroxamic acid  +, Methylhydroxamic acid  +, N-Hydroxyacetamide  +, and Lithostat  +