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Amphotericin B

Name: Amphotericin B
Description: Amphotericin B shows a high order of in vitro activity against many species of fungi. Histoplasma capsulatum, Coccidioides immitis, Candida species, Blastomyces dermatitidis, Rhodotorula, Cryptococcus neoformans, Sporothrix schenckii, Mucor mucedo, and Aspergillus fumigatus are all inhibited by concentrations of amphotericin B ranging from 0.03 to 1.0 mcg/mL in vitro. While Candida albicans is generally quite susceptible to amphotericin B, non-albicans species may be less susceptible. Pseudallescheria boydii and Fusarium sp. are often resistant to amphotericin B. The antibiotic is without effect on bacteria, rickettsiae, and viruses. Pharmacology: Amphotericin B shows a high order of in vitro activity against many species of fungi. Histoplasma capsulatum, Coccidioides immitis, Candida species, Blastomyces dermatitidis, Rhodotorula, Cryptococcus neoformans, Sporothrix schenckii, Mucor mucedo, and Aspergillus fumigatus are all inhibited by concentrations of amphotericin B ranging from 0.03 to 1.0 mcg/mL in vitro. While Candida albicans is generally quite susceptible to amphotericin B, non-albicans species may be less susceptible. Pseudallescheria boydii and Fusarium sp. are often resistant to amphotericin B. The antibiotic is without effect on bacteria, rickettsiae, and viruses. Mechanism of action: Amphotericin B is fungistatic or fungicidal depending on the concentration obtained in body fluids and the susceptibility of the fungus. The drug acts by binding to sterols in the cell membrane of susceptible fungi with a resultant change in membrane permeability allowing leakage of intracellular components. Ergosterol, the principal sterol in the fungal cytoplasmic membrane, is the target site of action of amphotericin B and the azoles. Amphotericin B, a polyene, binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death. Drug type: Approved. Investigational. Small Molecule. Drug category: Amebicides. Anti-Bacterial Agents. Antifungal Agents. Antiprotozoal Agents
Synonym(s): AMPH-B, Amphortericin B, Amphotericine B, Liposomal Amphotericin B, amphotericin B, ABLC, Abelcet, AmB, AmBisome, Ampho-Moronal, Amphocin, Amphotec, Amphotericin, Amphozone, Fungilin, Fungisone, Fungizone, Fungizone Intravenous, HSDB 3008 IAB, Halizon, IAB, LNS-AmB, Mysteclin-F, SinuNase, Tegopen
Has role: Drug
Super-category: Molecular entity
URL: http://www.drugbank.ca/drugs/DB00681
*Id: DB00681
Related to: Ergosterol biosynthetic protein 28
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Ccdbuser, Nifbot2



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Facts about Amphotericin BRDF feed
Commenttaken from DrugBank
CuratorAb  +
DefiningCitationhttp://www.drugbank.ca/drugs/DB00681  +
DefinitionAmphotericin B shows a high order of in vi Amphotericin B shows a high order of in vitro activity against many species of fungi. Histoplasma capsulatum, Coccidioides immitis, Candida species, Blastomyces dermatitidis, Rhodotorula, Cryptococcus neoformans, Sporothrix schenckii, Mucor mucedo, and Aspergillus fumigatus are all inhibited by concentrations of amphotericin B ranging from 0.03 to 1.0 mcg/mL in vitro. While Candida albicans is generally quite susceptible to amphotericin B, non-albicans species may be less susceptible. Pseudallescheria boydii and Fusarium sp. are often resistant to amphotericin B. The antibiotic is without effect on bacteria, rickettsiae, and viruses. Pharmacology: Amphotericin B shows a high order of in vitro activity against many species of fungi. Histoplasma capsulatum, Coccidioides immitis, Candida species, Blastomyces dermatitidis, Rhodotorula, Cryptococcus neoformans, Sporothrix schenckii, Mucor mucedo, and Aspergillus fumigatus are all inhibited by concentrations of amphotericin B ranging from 0.03 to 1.0 mcg/mL in vitro. While Candida albicans is generally quite susceptible to amphotericin B, non-albicans species may be less susceptible. Pseudallescheria boydii and Fusarium sp. are often resistant to amphotericin B. The antibiotic is without effect on bacteria, rickettsiae, and viruses. Mechanism of action: Amphotericin B is fungistatic or fungicidal depending on the concentration obtained in body fluids and the susceptibility of the fungus. The drug acts by binding to sterols in the cell membrane of susceptible fungi with a resultant change in membrane permeability allowing leakage of intracellular components. Ergosterol, the principal sterol in the fungal cytoplasmic membrane, is the target site of action of amphotericin B and the azoles. Amphotericin B, a polyene, binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death. Drug type: Approved. Investigational. Small Molecule. Drug category: Amebicides. Anti-Bacterial Agents. Antifungal Agents. Antiprotozoal Agents s. Antifungal Agents. Antiprotozoal Agents
Has roleDrug  +
IdDB00681  +
LabelAmphotericin B  +
ModifiedDate14 April 2014  +
RelatedToErgosterol biosynthetic protein 28  +
SuperCategoryMolecular entity  +
SynonymAMPH-B  +, Amphortericin B  +, Amphotericine B  +, Liposomal Amphotericin B  +, amphotericin B  +, ABLC  +, Abelcet  +, AmB  +, AmBisome  +, Ampho-Moronal  +, Amphocin  +, Amphotec  +, Amphotericin  +, Amphozone  +, Fungilin  +, Fungisone  +, Fungizone  +, Fungizone Intravenous  +, HSDB 3008 IAB  +, Halizon  +, IAB  +, LNS-AmB  +, Mysteclin-F  +, SinuNase  +, and Tegopen  +