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Amyl Nitrite

Name: Amyl Nitrite
Description: Amyl Nitrite is an antihypertensive medicine. Amyl nitrite is employed medically to treat heart diseases such as angina and to treat cyanide poisoning. Like other alkyl nitrites, amyl nitrite is bioactive in mammals, being a vasodilator which is the basis of its use as a prescription medicine. As an inhalant, it also has psychoactive effect which has led to illegal drug use. Pharmacology: Amyl nitrite, in common with other alkyl nitrites, is a potent vasodilator. It expands blood vessels, resulting in lowering of the blood pressure. Alkyl nitrite functions as a source of nitric oxide, which signals for relaxation of the involuntary muscles. Physical effects include decrease in blood pressure, headache, flushing of the face, increased heart rate, dizziness, and relaxation of involuntary muscles, especially the blood vessel walls and the anal sphincter. There are no withdrawal symptoms. Mechanism of action: Amyl nitrite's antianginal action is thought to be the result of a reduction in systemic and pulmonary arterial pressure (afterload) and decreased cardiac output because of peripheral vasodilation, rather than coronary artery dilation. As an antidote (to cyanide poisoning), amyl nitrite promotes formation of methemoglobin, which combines with cyanide to form nontoxic cyanmethemoglobin. Drug type: Approved. Small Molecule. Drug category: Vasodilator Agents
Synonym(s): 3-Methylbutanol nitrite, 3-Methylbutyl nitrite, Amilnitrit, Amilnitrite, Amyl nitrit, Amyl nitrite I, Amyl nitrosum, IPN, Isoamyl nitrite, Isopentyl nitrite, Nitramyl, 3-methylbutyl ester, Nitrous acid, isopentyl ester, Pentanoli nitris, Pentyl nitrite, Aspiral, Vaporole, 3-methylbutyl nitrite, C5H11NO2, amyl nitrite, snappers, poppers
Has role: Drug, Drug of abuse role, Inhalant
Super-category: Alkyl nitrite
URL: http://www.drugbank.ca/drugs/DB01612
Id: CHEBI:2691
Link to OWL / RDF: Download this content as OWL/RDF


street names: snappers, poppers



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Facts about Amyl NitriteRDF feed
Commenttaken from DrugBank
CurationStatusuncurated  +
CuratorAb  +
DefiningCitationhttp://www.drugbank.ca/drugs/DB01612  +
DefinitionAmyl Nitrite is an antihypertensive medici Amyl Nitrite is an antihypertensive medicine. Amyl nitrite is employed medically to treat heart diseases such as angina and to treat cyanide poisoning. Like other alkyl nitrites, amyl nitrite is bioactive in mammals, being a vasodilator which is the basis of its use as a prescription medicine. As an inhalant, it also has psychoactive effect which has led to illegal drug use. Pharmacology: Amyl nitrite, in common with other alkyl nitrites, is a potent vasodilator. It expands blood vessels, resulting in lowering of the blood pressure. Alkyl nitrite functions as a source of nitric oxide, which signals for relaxation of the involuntary muscles. Physical effects include decrease in blood pressure, headache, flushing of the face, increased heart rate, dizziness, and relaxation of involuntary muscles, especially the blood vessel walls and the anal sphincter. There are no withdrawal symptoms. Mechanism of action: Amyl nitrite's antianginal action is thought to be the result of a reduction in systemic and pulmonary arterial pressure (afterload) and decreased cardiac output because of peripheral vasodilation, rather than coronary artery dilation. As an antidote (to cyanide poisoning), amyl nitrite promotes formation of methemoglobin, which combines with cyanide to form nontoxic cyanmethemoglobin. Drug type: Approved. Small Molecule. Drug category: Vasodilator Agents olecule. Drug category: Vasodilator Agents
Has roleDrug  +, Drug of abuse role  +, and Inhalant  +
IdCHEBI:2691  +
LabelAmyl Nitrite  +
ModifiedDate12 August 2014  +
SuperCategoryAlkyl nitrite  +
Synonym3-Methylbutanol nitrite  +, 3-Methylbutyl nitrite  +, Amilnitrit  +, Amilnitrite  +, Amyl nitrit  +, Amyl nitrite I  +, Amyl nitrosum  +, IPN  +, Isoamyl nitrite  +, Isopentyl nitrite  +, Nitramyl  +, 3-methylbutyl ester  +, Nitrous acid  +, isopentyl ester  +, Pentanoli nitris  +, Pentyl nitrite  +, Aspiral  +, Vaporole  +, 3-methylbutyl nitrite  +, C5H11NO2  +, amyl nitrite  +, snappers  +, and poppers  +