Aromatic L-Amino Acid Decarboxylase

Current revision (unreviewed)

Name:	Aromatic L-Amino Acid Decarboxylase
Description:	A protein that is a translation product of the DDC gene or a 1:1 ortholog thereof. It is a synthetic enzyme that is involved in the second step of the catecholamine synthesis, in which it converts L-DOPA to dopamine via the removal of the carboxyl group from the alpha-carbon on the side chain, with the subsequent liberation of free carbon dioxide. This process also involves the co-factor Pyridoxal phosphate. AADC acts on a variety of aromatic amino acids besides DOPA. (Adapted from "Principles of Neuropsychopharmacology" and PRotein Ontology).
Synonym(s):	DOPA decarboxylase; DDC; Dopa decarboxylase; Dopa-decarboxylase; DOPA-decarboxylase; Aromatic L-amino acid decarboxylase; EC 4.1.1.28;
Is part of:	Catecholamine system, Dopaminergic system
Related to:	Dopamine, L Dopa, Dopaminergic system, Pyridoxal Phosphate
Has role:	Synthetic Enzyme
Abbreviation:	AADC
Super-category:	Protein
URL:	PRotein Ontology; "Principles of Neuropsychopharmacology" Feldman, Meyer, and Quenzer
Id:	PRO:000006342
Link to OWL / RDF:	Download this content as OWL/RDF

Contributors

Abbrev	AADC +
CurationStatus	uncurated +
DefiningCitation	PRotein Ontology; "Principles of Neuropsychopharmacology" Feldman, Meyer, and Quenzer +
Definition	A protein that is a translation product of … A protein that is a translation product of the DDC gene or a 1:1 ortholog thereof. It is a synthetic enzyme that is involved in the second step of the catecholamine synthesis, in which it converts L-DOPA to dopamine via the removal of the carboxyl group from the alpha-carbon on the side chain, with the subsequent liberation of free carbon dioxide. This process also involves the co-factor Pyridoxal phosphate. AADC acts on a variety of aromatic amino acids besides DOPA. (Adapted from "Principles of Neuropsychopharmacology" and PRotein Ontology). psychopharmacology" and PRotein Ontology).
Has role	Synthetic Enzyme +
Id	PRO:000006342 +
Is part of	Catecholamine system +, and Dopaminergic system +
Label	Aromatic L-Amino Acid Decarboxylase +
ModifiedDate	1 May 2010 +
RelatedTo	Dopamine +, L Dopa +, Dopaminergic system +, and Pyridoxal Phosphate +
SuperCategory	Protein +
Synonym	DOPA decarboxylase; DDC; Dopa decarboxylase; Dopa-decarboxylase; DOPA-decarboxylase; Aromatic L-amino acid decarboxylase; EC 4.1.1.28; +