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Aromatic L-Amino Acid Decarboxylase

Name: Aromatic L-Amino Acid Decarboxylase
Description: A protein that is a translation product of the DDC gene or a 1:1 ortholog thereof. It is a synthetic enzyme that is involved in the second step of the catecholamine synthesis, in which it converts L-DOPA to dopamine via the removal of the carboxyl group from the alpha-carbon on the side chain, with the subsequent liberation of free carbon dioxide. This process also involves the co-factor Pyridoxal phosphate. AADC acts on a variety of aromatic amino acids besides DOPA. (Adapted from "Principles of Neuropsychopharmacology" and PRotein Ontology).
Synonym(s): DOPA decarboxylase; DDC; Dopa decarboxylase; Dopa-decarboxylase; DOPA-decarboxylase; Aromatic L-amino acid decarboxylase; EC 4.1.1.28;
Abbreviation: AADC
Is part of: Catecholamine system, Dopaminergic system
Has role: Synthetic Enzyme
Super-category: Protein
URL: PRotein Ontology; "Principles of Neuropsychopharmacology" Feldman, Meyer, and Quenzer
Id: PRO:000006342
Related to: Dopamine, L Dopa, Dopaminergic system, Pyridoxal Phosphate
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Facts about Aromatic L-Amino Acid DecarboxylaseRDF feed
AbbrevAADC  +
CurationStatusuncurated  +
DefiningCitationPRotein Ontology; "Principles of Neuropsychopharmacology" Feldman, Meyer, and Quenzer  +
DefinitionA protein that is a translation product of A protein that is a translation product of the DDC gene or a 1:1 ortholog thereof. It is a synthetic enzyme that is involved in the second step of the catecholamine synthesis, in which it converts L-DOPA to dopamine via the removal of the carboxyl group from the alpha-carbon on the side chain, with the subsequent liberation of free carbon dioxide. This process also involves the co-factor Pyridoxal phosphate. AADC acts on a variety of aromatic amino acids besides DOPA. (Adapted from "Principles of Neuropsychopharmacology" and PRotein Ontology). psychopharmacology" and PRotein Ontology).
Has roleSynthetic Enzyme  +
IdPRO:000006342  +
Is part ofCatecholamine system  +, and Dopaminergic system  +
LabelAromatic L-Amino Acid Decarboxylase  +
ModifiedDate1 May 2010  +
RelatedToDopamine  +, L Dopa  +, Dopaminergic system  +, and Pyridoxal Phosphate  +
SuperCategoryProtein  +
SynonymDOPA decarboxylase; DDC; Dopa decarboxylase; Dopa-decarboxylase; DOPA-decarboxylase; Aromatic L-amino acid decarboxylase; EC 4.1.1.28;  +