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Atropine

Name: Atropine
Description: An alkaloid, originally from Atropa belladonna, but found in other plants, mainly solanaceae. (PubChem) Pharmacology: Atropine, a naturally occurring belladonna alkaloid, is a racemic mixture of equal parts of d- and l-hyoscyamine, whose activity is due almost entirely to the levo isomer of the drug. Atropine is commonly classified as an anticholinergic or antiparasympathetic (parasympatholytic) drug. More precisely, however, it is termed an antimuscarinic agent since it antagonizes the muscarine-like actions of acetylcholine and other choline esters. Adequate doses of atropine abolish various types of reflex vagal cardiac slowing or asystole. The drug also prevents or abolishes bradycardia or asystole produced by injection of choline esters, anticholinesterase agents or other parasympathomimetic drugs, and cardiac arrest produced by stimulation of the vagus. Atropine may also lessen the degree of partial heart block when vagal activity is an etiologic factor. Atropine in clinical doses counteracts the peripheral dilatation and abrupt decrease in blood pressure produced by choline esters. However, when given by itself, atropine does not exert a striking or uniform effect on blood vessels or blood pressure. Mechanism of action: Generally, atropine lowers the "rest and digest" activity of all muscles and glands regulated by the parasympathetic nervous system. This occurs because atropine is a competitive inhibitor of the muscarinic acetylcholine receptors (acetylcholine is the neurotransmitter used by the parasympathetic nervous system). Drug type: Approved. Small Molecule. Drug category: Adjuvants, Anesthesia. Anti-Arrhythmia Agents. Bronchodilator Agents. Muscarinic Antagonists. Mydriatics. Parasympatholytics
Synonym(s): Atropin (German), Atropina (Italian), Atropine Sulfate, DL-Hyoscyamine, DL-Tropyl tropate, Atnaa, Atropair, Atropen, Atropin, Atropin-flexiolen, Atropine Care, Atropine Sulfate Ansyr Plastic Syringe, Atropine Sulfate S, O, P, Atropinol, Atropisol, Atrosulf, Equipin, Eyesules, Homapin-10, Homapin-5, I-Tropine, Isopto Atropine, Isopto-atropine, Minims Atropine, Ocu-Tropine, Tropine tropate, Troyl tropate
Related to: Muscarinic acetylcholine receptor M3, Muscarinic acetylcholine receptor M1, Muscarinic acetylcholine receptor M5, Muscarinic acetylcholine receptor M4, Acetylcholinesterase, Muscarinic acetylcholine receptor M2, Phospholipase A2 VRV-PL-VIIIa
Has role: Drug
Super-category: Molecular entity
URL: http://www.drugbank.ca/drugs/DB00572
Id: CHEBI_16684
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Commenttaken from DrugBank
CurationStatusuncurated  +
CuratorAb  +
DefiningCitationhttp://www.drugbank.ca/drugs/DB00572  +
DefinitionAn alkaloid, originally from Atropa bellad An alkaloid, originally from Atropa belladonna, but found in other plants, mainly solanaceae. (PubChem) Pharmacology: Atropine, a naturally occurring belladonna alkaloid, is a racemic mixture of equal parts of d- and l-hyoscyamine, whose activity is due almost entirely to the levo isomer of the drug. Atropine is commonly classified as an anticholinergic or antiparasympathetic (parasympatholytic) drug. More precisely, however, it is termed an antimuscarinic agent since it antagonizes the muscarine-like actions of acetylcholine and other choline esters. Adequate doses of atropine abolish various types of reflex vagal cardiac slowing or asystole. The drug also prevents or abolishes bradycardia or asystole produced by injection of choline esters, anticholinesterase agents or other parasympathomimetic drugs, and cardiac arrest produced by stimulation of the vagus. Atropine may also lessen the degree of partial heart block when vagal activity is an etiologic factor. Atropine in clinical doses counteracts the peripheral dilatation and abrupt decrease in blood pressure produced by choline esters. However, when given by itself, atropine does not exert a striking or uniform effect on blood vessels or blood pressure. Mechanism of action: Generally, atropine lowers the "rest and digest" activity of all muscles and glands regulated by the parasympathetic nervous system. This occurs because atropine is a competitive inhibitor of the muscarinic acetylcholine receptors (acetylcholine is the neurotransmitter used by the parasympathetic nervous system). Drug type: Approved. Small Molecule. Drug category: Adjuvants, Anesthesia. Anti-Arrhythmia Agents. Bronchodilator Agents. Muscarinic Antagonists. Mydriatics. Parasympatholytics ntagonists. Mydriatics. Parasympatholytics
Has roleDrug  +
IdCHEBI_16684  +
LabelAtropine  +
ModifiedDate14 April 2014  +
RelatedToMuscarinic acetylcholine receptor M3  +, Muscarinic acetylcholine receptor M1  +, Muscarinic acetylcholine receptor M5  +, Muscarinic acetylcholine receptor M4  +, Acetylcholinesterase  +, Muscarinic acetylcholine receptor M2  +, and Phospholipase A2 VRV-PL-VIIIa  +
SuperCategoryMolecular entity  +
SynonymAtropin (German)  +, Atropina (Italian)  +, Atropine Sulfate  +, DL-Hyoscyamine  +, DL-Tropyl tropate  +, Atnaa  +, Atropair  +, Atropen  +, Atropin  +, Atropin-flexiolen  +, Atropine Care  +, Atropine Sulfate Ansyr Plastic Syringe  +, Atropine Sulfate S  +, O  +, P  +, Atropinol  +, Atropisol  +, Atrosulf  +, Equipin  +, Eyesules  +, Homapin-10  +, Homapin-5  +, I-Tropine  +, Isopto Atropine  +, Isopto-atropine  +, Minims Atropine  +, Ocu-Tropine  +, Tropine tropate  +, and Troyl tropate  +