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Auranofin

Name: Auranofin
Description: Auranofin is a organogold compound classified by the World Health Organization as an antirheumatic agent. Auranofin appears to induce heme oxygenase 1 (HO-1) mRNA. Heme oxygenase 1 is an inducible heme-degrading enzyme with anti-inflammatory properties. Pharmacology: Auranofin is a gold salt used in treating inflammatory arthritis. Gold salts are called second-line drugs because they are often considered when the arthritis progresses in spite of antiinflammatory drugs (NSAIDs and corticosteroids). Mechanism of action: Exactly how auranofin works is not well understood. In patients with inflammatory arthritis, such as adult and juvenile rheumatoid arthritis, gold salts can decrease the inflammation of the joint lining. This effect can prevent destruction of bone and cartilage. Drug type: Approved. Small Molecule. Drug category: Antirheumatic Agents, Gold
Synonym(s): Auroafen, Ridaura
Related to: Serum albumin, Peroxiredoxin-5, mitochondrial, Inhibitor of nuclear factor kappa-B kinase subunit beta
Has role: Drug
Super-category: Molecular entity
URL: http://www.drugbank.ca/drugs/DB00995
Id: DB00995
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Commenttaken from DrugBank
CuratorAb  +
DefiningCitationhttp://www.drugbank.ca/drugs/DB00995  +
DefinitionAuranofin is a organogold compound classif Auranofin is a organogold compound classified by the World Health Organization as an antirheumatic agent. Auranofin appears to induce heme oxygenase 1 (HO-1) mRNA. Heme oxygenase 1 is an inducible heme-degrading enzyme with anti-inflammatory properties. Pharmacology: Auranofin is a gold salt used in treating inflammatory arthritis. Gold salts are called second-line drugs because they are often considered when the arthritis progresses in spite of antiinflammatory drugs (NSAIDs and corticosteroids). Mechanism of action: Exactly how auranofin works is not well understood. In patients with inflammatory arthritis, such as adult and juvenile rheumatoid arthritis, gold salts can decrease the inflammation of the joint lining. This effect can prevent destruction of bone and cartilage. Drug type: Approved. Small Molecule. Drug category: Antirheumatic Agents, Gold Drug category: Antirheumatic Agents, Gold
Has roleDrug  +
IdDB00995  +
LabelAuranofin  +
ModifiedDate14 April 2014  +
RelatedToSerum albumin  +, Peroxiredoxin-5  +, Mitochondrial  +, and Inhibitor of nuclear factor kappa-B kinase subunit beta  +
SuperCategoryMolecular entity  +
SynonymAuroafen  +, and Ridaura  +