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Azlocillin

Name: Azlocillin
Description: A semisynthetic ampicillin-derived acylureido penicillin. (PubChem) Pharmacology: Azlocillin, similar to mezlocillin and piperacillin, is an acylampicillin with an extended spectrum of activity and greater in vitro potency than the carboxy penicillins. Azlocillin demonstrates antibacterial activity against a broad spectrum of bacteria, including Pseudomonas aeruginosa, and, in contrast to most cephalosporins, exhibits activity against enterococci. Mechanism of action: By binding to specific penicillin-binding proteins (PBPs) located inside the bacterial cell wall, azlocillin inhibits the third and last stage of bacterial cell wall synthesis. Cell lysis is then mediated by bacterial cell wall autolytic enzymes such as autolysins; it is possible that azlocillin interferes with an autolysin inhibitor. Drug type: Approved. Small Molecule. Drug category: Anti-Bacterial Agents. Penicillins
Synonym(s): Azlocilina (INN-Spanish), Azlocillin sodium salt, Azlocilline (INN-French), Azlocillinum (INN-Latin), Azlin, Bayer Brand of Azlocillin, Securopen
Has role: Drug
Super-category: Molecular entity
URL: http://www.drugbank.ca/drugs/DB01061
*Id: CHEBI:2956
Related to: Penicillin-binding proteins 1A/1B
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Facts about AzlocillinRDF feed
Commenttaken from DrugBank
CurationStatusuncurated  +
CuratorAb  +
DefiningCitationhttp://www.drugbank.ca/drugs/DB01061  +
DefinitionA semisynthetic ampicillin-derived acylure A semisynthetic ampicillin-derived acylureido penicillin. (PubChem) Pharmacology: Azlocillin, similar to mezlocillin and piperacillin, is an acylampicillin with an extended spectrum of activity and greater in vitro potency than the carboxy penicillins. Azlocillin demonstrates antibacterial activity against a broad spectrum of bacteria, including Pseudomonas aeruginosa, and, in contrast to most cephalosporins, exhibits activity against enterococci. Mechanism of action: By binding to specific penicillin-binding proteins (PBPs) located inside the bacterial cell wall, azlocillin inhibits the third and last stage of bacterial cell wall synthesis. Cell lysis is then mediated by bacterial cell wall autolytic enzymes such as autolysins; it is possible that azlocillin interferes with an autolysin inhibitor. Drug type: Approved. Small Molecule. Drug category: Anti-Bacterial Agents. Penicillins tegory: Anti-Bacterial Agents. Penicillins
Has roleDrug  +
IdCHEBI:2956  +
LabelAzlocillin  +
ModifiedDate12 August 2014  +
RelatedToPenicillin-binding proteins 1A/1B  +
SuperCategoryMolecular entity  +
SynonymAzlocilina (INN-Spanish)  +, Azlocillin sodium salt  +, Azlocilline (INN-French)  +, Azlocillinum (INN-Latin)  +, Azlin  +, Bayer Brand of Azlocillin  +, and Securopen  +