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Bromodiphenhydramine

Name: Bromodiphenhydramine
Description: Bromodiphenhydramine is an ethanolamine antihistamine with antimicrobial property. Bromodiphenhydramine is used in the control of cutaneous allergies. Ethanolamine antihistamines produce marked sedation in most patients Pharmacology: Bromodiphenhydramine is an antihistamine of the ethanolamine class. Ethanolamine antihistamines have significant antimuscarinic activity and produce marked sedation in most patients. In addition to the usual allergic symptoms, the drug also treats irritant cough and nausea, vomiting, and vertigo associated with motion sickness. It also is used commonly to treat drug-induced extrapyramidal symptoms as well as to treat mild cases of Parkinson's disease. Rather than preventing the release of histamine, as do cromolyn and nedocromil, Bromodiphenhydramine competes with free histamine for binding at HA-receptor sites. Bromodiphenhydramine competitively antagonizes the effects of histamine on HA-receptors in the GI tract, uterus, large blood vessels, and bronchial muscle. Ethanolamine derivatives have greater anticholinergic activity than do other antihistamines, which probably accounts for the antidyskinetic action of Bromodiphenhydramine. This anticholinergic action appears to be due to a central antimuscarinic effect, which also may be responsible for its antiemetic effects, although the exact mechanism is unknown. Mechanism of action: Bromodiphenhydramine competes with free histamine for binding at HA-receptor sites. This antagonizes the effects of histamine on HA-receptors, leading to a reduction of the negative symptoms brought on by histamine HA-receptor binding. Drug type: Approved. Small Molecule. Drug category: Antihistamines
Synonym(s): Ambodryl Hydrochloride, Amodryl, Bromanautine, Bromazin, Bromazine, Bromazine hydrochloride, Bromdiphenhydramine, Bromdiphenhydramine hydrochloride, Bromdiphenylhydramine Hydrochloride, Bromodiphenhydramine hydrochloride, Bromo-Benadryl, Bromo-Benzdryl, Deserol, Histabromamine, Neo-Benadryl
Has role: Drug
Super-category: Molecular entity
URL: http://www.drugbank.ca/drugs/DB01237
Id: DB01237
Related to: Histamine H1 receptor
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Commenttaken from DrugBank
CuratorAb  +
DefiningCitationhttp://www.drugbank.ca/drugs/DB01237  +
DefinitionBromodiphenhydramine is an ethanolamine an Bromodiphenhydramine is an ethanolamine antihistamine with antimicrobial property. Bromodiphenhydramine is used in the control of cutaneous allergies. Ethanolamine antihistamines produce marked sedation in most patients Pharmacology: Bromodiphenhydramine is an antihistamine of the ethanolamine class. Ethanolamine antihistamines have significant antimuscarinic activity and produce marked sedation in most patients. In addition to the usual allergic symptoms, the drug also treats irritant cough and nausea, vomiting, and vertigo associated with motion sickness. It also is used commonly to treat drug-induced extrapyramidal symptoms as well as to treat mild cases of Parkinson's disease. Rather than preventing the release of histamine, as do cromolyn and nedocromil, Bromodiphenhydramine competes with free histamine for binding at HA-receptor sites. Bromodiphenhydramine competitively antagonizes the effects of histamine on HA-receptors in the GI tract, uterus, large blood vessels, and bronchial muscle. Ethanolamine derivatives have greater anticholinergic activity than do other antihistamines, which probably accounts for the antidyskinetic action of Bromodiphenhydramine. This anticholinergic action appears to be due to a central antimuscarinic effect, which also may be responsible for its antiemetic effects, although the exact mechanism is unknown. Mechanism of action: Bromodiphenhydramine competes with free histamine for binding at HA-receptor sites. This antagonizes the effects of histamine on HA-receptors, leading to a reduction of the negative symptoms brought on by histamine HA-receptor binding. Drug type: Approved. Small Molecule. Drug category: Antihistamines ll Molecule. Drug category: Antihistamines
Has roleDrug  +
IdDB01237  +
LabelBromodiphenhydramine  +
ModifiedDate14 April 2014  +
RelatedToHistamine H1 receptor  +
SuperCategoryMolecular entity  +
SynonymAmbodryl Hydrochloride  +, Amodryl  +, Bromanautine  +, Bromazin  +, Bromazine  +, Bromazine hydrochloride  +, Bromdiphenhydramine  +, Bromdiphenhydramine hydrochloride  +, Bromdiphenylhydramine Hydrochloride  +, Bromodiphenhydramine hydrochloride  +, Bromo-Benadryl  +, Bromo-Benzdryl  +, Deserol  +, Histabromamine  +, and Neo-Benadryl  +