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Ciprofloxacin

Name: Ciprofloxacin
Description: A broad-spectrum antimicrobial carboxyfluoroquinoline. (PubChem) Pharmacology: Ciprofloxacin is a broad-spectrum antiinfective agent of the fluoroquinolone class. Ciprofloxacin has in vitro activity against a wide range of gram-negative and gram-positive microorganisms. The mechanism of action of quinolones, including ciprofloxacin, is different from that of other antimicrobial agents such as beta-lactams, macrolides, tetracyclines, or aminoglycosides; therefore, organisms resistant to these drugs may be susceptible to ciprofloxacin. There is no known cross-resistance between ciprofloxacin and other classes of antimicrobials. Notably the drug has 100 times higher affinity for bacterial DNA gyrase than for mammalian. Mechanism of action: The bactericidal action of ciprofloxacin results from inhibition of the enzymes topoisomerase II (DNA gyrase) and topoisomerase IV, which are required for bacterial DNA replication, transcription, repair, and recombination. Drug type: Approved. Investigational. Small Molecule. Drug category: Anti-Infective Agents. Anti-Infectives. Nucleic Acid Synthesis Inhibitors. Quinolones
Synonym(s): Ciprofloxacin HCl, Ciprofloxacin dihydrochloride, Ciprofloxacin hydrochloride, Ciprofloxacin monohydrochloride, Ciprofloxacina, ciprofloxacin, Bacquinor, Baycip, Bernoflox, Ciflox, Cifloxin, Ciloxan, Ciprinol, Cipro, Cipro I, V, Cipro XL, Cipro XR, Ciprobay, Ciprocinol, Ciprodar, Cipromycin, Ciproquinol, Ciproxan, Ciproxin, Flociprin, Floxin, Ocuflox, Proquin XR, Septicide, Velomonit
Has role: Drug
Super-category: Molecular entity
URL: http://www.drugbank.ca/drugs/DB00537
*Id: DB00537
Related to: DNA gyrase subunit A, DNA topoisomerase 4 subunit A, Serum albumin, DNA topoisomerase 2-alpha, Acriflavine resistance protein B
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Facts about CiprofloxacinRDF feed
Commenttaken from DrugBank
CuratorAb  +
DefiningCitationhttp://www.drugbank.ca/drugs/DB00537  +
DefinitionA broad-spectrum antimicrobial carboxyfluo A broad-spectrum antimicrobial carboxyfluoroquinoline. (PubChem) Pharmacology: Ciprofloxacin is a broad-spectrum antiinfective agent of the fluoroquinolone class. Ciprofloxacin has in vitro activity against a wide range of gram-negative and gram-positive microorganisms. The mechanism of action of quinolones, including ciprofloxacin, is different from that of other antimicrobial agents such as beta-lactams, macrolides, tetracyclines, or aminoglycosides; therefore, organisms resistant to these drugs may be susceptible to ciprofloxacin. There is no known cross-resistance between ciprofloxacin and other classes of antimicrobials. Notably the drug has 100 times higher affinity for bacterial DNA gyrase than for mammalian. Mechanism of action: The bactericidal action of ciprofloxacin results from inhibition of the enzymes topoisomerase II (DNA gyrase) and topoisomerase IV, which are required for bacterial DNA replication, transcription, repair, and recombination. Drug type: Approved. Investigational. Small Molecule. Drug category: Anti-Infective Agents. Anti-Infectives. Nucleic Acid Synthesis Inhibitors. Quinolones leic Acid Synthesis Inhibitors. Quinolones
Has roleDrug  +
IdDB00537  +
LabelCiprofloxacin  +
ModifiedDate14 April 2014  +
RelatedToDNA gyrase subunit A  +, DNA topoisomerase 4 subunit A  +, Serum albumin  +, DNA topoisomerase 2-alpha  +, and Acriflavine resistance protein B  +
SuperCategoryMolecular entity  +
SynonymCiprofloxacin HCl  +, Ciprofloxacin dihydrochloride  +, Ciprofloxacin hydrochloride  +, Ciprofloxacin monohydrochloride  +, Ciprofloxacina  +, ciprofloxacin  +, Bacquinor  +, Baycip  +, Bernoflox  +, Ciflox  +, Cifloxin  +, Ciloxan  +, Ciprinol  +, Cipro  +, Cipro I  +, V  +, Cipro XL  +, Cipro XR  +, Ciprobay  +, Ciprocinol  +, Ciprodar  +, Cipromycin  +, Ciproquinol  +, Ciproxan  +, Ciproxin  +, Flociprin  +, Floxin  +, Ocuflox  +, Proquin XR  +, Septicide  +, and Velomonit  +