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Cochlear nucleus (dorsal) unipolar brush cell

Name: Cochlear nucleus (dorsal) unipolar brush cell
Description: Unipolar brush cells are characterized by having one dendrite that terminates in a paintbrush-like structure of dendrioles that receives input from a single mossy fiber terminal. The axon usually emanates from the opposite pole, branches 1-3 times and ends in mossy terminals. They were defined by E. Mugnaini and his colleagues in the 1990s.[1]
Synonym(s): DCN glutamatergic cell, Dorsal cochlear nucleus glutamatergic cell
Abbreviation: UBC[2]
Has role: Intrinsic neuron role[3]
Super-category: Neuron
URL: 8106879
Id: nifext_135
Related to: Cerelllum unipolar brush cell[2]
Organism: Vertebrata
Link to OWL / RDF: Download this content as OWL/RDF

Soma Specific Properties

Cell Soma Shape: Spherical[4]
Cell Soma Size: Small soma[4]
Soma Location: dorsal cochlear nucleus[4]

Dendrite Specific Properties

Dendrite location: Brush of dendrites is short and lies near the cell body[4]
Spine density on dendrites: Smooth
Branching type: unipolar[5]

Axon Specific Properties

Axon myelination: unmyelinated[6]
Axon projection laterality: ipsilateral[3]
Origin of axon: soma[3]
Location of distant axon arborization: none
Location of local axon arborization: within the same granule cell domain as the cell body[3]

Intrinsic Properties

Neurotransmitter released: glutamate[3]
Neurotransmitter receptors: GluR2, GluR3, GluR5/6/7, NR1, GABA A-gated anionic channel[7]
Molecular constituents: calretinin, mGluR1alpha, epidermal growth factor substrate 8 (Eps8), T-box gene (Tbr2), alpha 6 GABA-A receptor, actin[8]


References

  1. Harris J et al. (1995) Properties of transmission at a giant glutamatergic synapse in cerebellum: the mossy fiber-unipolar brush cell synapse. J Neurophysiol 74: 24-42 PubMed
  2. 2.0 2.1 Mugnaini E et al. (2011) The unipolar brush cell: a remarkable neuron finally receiving deserved attention. Brain Res Rev 66: 220-45 PubMed
  3. 3.0 3.1 3.2 3.3 3.4 Rossi DJ et al. (1995) Properties of transmission at a giant glutamatergic synapse in cerebellum: the mossy fiber-unipolar brush cell synapse. J Neurophysiol 74: 24-42 PubMed
  4. 4.0 4.1 4.2 4.3 Diño MR & Mugnaini E (2008) Distribution and phenotypes of unipolar brush cells in relation to the granule cell system of the rat cochlear nucleus. Neuroscience 154: 29-50 PubMed
  5. Diño MR et al. (1995) Properties of transmission at a giant glutamatergic synapse in cerebellum: the mossy fiber-unipolar brush cell synapse. J Neurophysiol 74: 24-42 PubMed
  6. Diño MR et al. (2000) Unipolar brush cell: a potential feedforward excitatory interneuron of the cerebellum. Neuroscience 98: 625-36 PubMed
  7. Diño MR et al. (1995) Glutamate receptor subunits at mossy fiber-unipolar brush cell synapses: light and electron microscopic immunocytochemical study in cerebellar cortex of rat and cat. J Comp Neurol 357: 145-60 PubMed
  8. Diño MR et al. (2000) Postsynaptic actin filaments at the giant mossy fiber-unipolar brush cell synapse. Synapse 38: 499-510 PubMed

Notes

This page uses this default form:Petilla_neuron

  • Notes on soma location: granule cell domains, including those in the dorsal cochlear nucleus, subpeduncular corner but not the granule cell lamin


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Facts about Cochlear nucleus (dorsal) unipolar brush cellRDF feed
AbbrevUBC  +
AxonMyelinationunmyelinated  +
AxonProjectionLateralityipsilateral  +
BranchingMetricsunipolar  +
CellSomaShapeCategory:Spherical   +
CellSomaSizeSmall soma  +
Created5 September 2007  +
CurationStatusuncurated  +
DefiningCitation8106879  +
DefinitionUnipolar brush cells are characterized by Unipolar brush cells are characterized by having one dendrite that terminates in a paintbrush-like structure of dendrioles that receives input from a single mossy fiber terminal. The axon usually emanates from the opposite pole, branches 1-3 times and ends in mossy terminals. They were defined by E. Mugnaini and his colleagues in the 1990s. Mugnaini and his colleagues in the 1990s.
DendriteLocationBrush of dendrites is short and lies near the cell body  +
Has default formThis property is a special property in this wiki.Petilla neuron  +
Has roleIntrinsic neuron role  +
Idnifext_135  +
LabelCochlear nucleus (dorsal) unipolar brush cell  +
Located inDorsal cochlear nucleus  +
LocationOfAxonArborizationNone  +
LocationOfLocalAxonArborizationWithin the same granule cell domain as the cell body  +
ModifiedDate8 August 2013  +
MolecularConstituentsCalretinin  +, MGluR1alpha  +, Epidermal growth factor substrate 8 (Eps8)  +, T-box gene (Tbr2)  +, Alpha 6 GABA-A receptor  +, and Actin  +
NeurotransmitterGlutamate  +
NeurotransmitterReceptorsGluR2  +, GluR3  +, GluR5/6/7  +, NR1  +, and GABA A-gated anionic channel  +
OriginOfAxonsoma  +
Page has default formThis property is a special property in this wiki.Petilla neuron  +
RelatedToCerelllum unipolar brush cell  +
SpeciesVertebrata  +
SpineDensityOnDendritesSmooth  +
SuperCategoryNeuron  +
SynonymDCN glutamatergic cell  +, and Dorsal cochlear nucleus glutamatergic cell  +