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Colliculus Inferior GABAergic Principal Cell
| Name: | Colliculus Inferior GABAergic Principal Cell |
| Description: | Winer and colleagues (1996) first described that GABAergic neurons project to the medial geniculate body in cat. Peruzzi et al. (1997) showed that the cell type is also found in rats, and sends action potentials more rapidly than glutamatergic IC neurons. Ito and colleagues (2009) showed that the cell type is the largest neuron in the IC and receives dense VGLUT2-positive axosomatic terminals on the cell body. Other cell types such as glutamatergic neurons and small GABAergic neurons do not have such endings.[1] |
| Synonym(s): | large GABAergic (LG) neurons[1] |
| Has role: | Principal neuron role[2] |
| Super-category: | Neuron |
| URL: | Winer et al, 1996 |
| PMID: | PMID 8755593 |
| Publication link: | http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&Cmd=Retrieve&list_uids=8755593 |
| Id: | nlx_60854 |
| Defining criteria: | large soma with dense VGLUT2+ endings[2] |
| Organism: | Mammal |
| Link to OWL / RDF: | Download this content as OWL/RDF |
Soma Specific Properties
| Cell Soma Shape: | Multipolar[3] |
| Cell Soma Size: | Large soma[2] |
| Soma Location: | inferior colliculus[2] |
Dendrite Specific Properties
| Dendrite location: | Inferior colliculus[2] |
| Spine density on dendrites: | Smooth |
| Branching type: | stellate |
Axon Specific Properties
| Axon myelination: | myelinated[4] |
| Axon projection laterality: | ipsilateral |
| Origin of axon: | soma |
| Location of distant axon arborization: | medial geniculate body |
Intrinsic Properties
| Neurotransmitter released: | GABA[5] |
| Neurotransmitter receptors: | Glutamate-gated cationic channel, GABA-gated anionic channel, Glycine-gated chloride channel |
| Molecular constituents: | parvalbumin[6] |
| Defining Criteria: | large soma with dense VGLUT2+ endings [2] |
References
- ↑ 1.0 1.1 Ito T & Oliver DL (2012) The basic circuit of the IC: tectothalamic neurons with different patterns of synaptic organization send different messages to the thalamus. Front Neural Circuits 6: 48 PubMed
- ↑ 2.0 2.1 2.2 2.3 2.4 2.5 Ito T et al. (2009) Two classes of GABAergic neurons in the inferior colliculus. J Neurosci 29: 13860-9 PubMed
- ↑ Oliver DL et al. (1994) Morphology of GABAergic neurons in the inferior colliculus of the cat. J Comp Neurol 340: 27-42 PubMed
- ↑ 4.0 4.1 4.2 Saint Marie RL et al. (1997) Substrate for rapid feedforward inhibition of the auditory forebrain. Brain Res 765: 173-6 PubMed
- ↑ Winer JA et al. (1996) GABAergic feedforward projections from the inferior colliculus to the medial geniculate body. Proc Natl Acad Sci U S A 93: 8005-10 PubMed
- ↑ Fredrich M et al. (2009) Neuronal subtype identity in the rat auditory brainstem as defined by molecular profile and axonal projection. Exp Brain Res 195: 241-60 PubMed
- ↑ 7.0 7.1 Bartlett EL et al. (2000) Comparison of the fine structure of cortical and collicular terminals in the rat medial geniculate body. Neuroscience 100: 811-28 PubMed
Notes
This page uses this default form:Petilla_neuron
Facts about Colliculus Inferior GABAergic Principal CellRDF feed
| AxonDiameter | Mean: 1.63 micrometer + |
| AxonMyelination | myelinated + |
| AxonProjectionLaterality | ipsilateral + |
| AxonTract | Brachium of the inferior colliculus + |
| BranchingMetrics | stellate + |
| CellSomaShape | Category:Multipolar + |
| CellSomaSize | Large soma + |
| CellularSynapticTarget | Medial geniculate body stellate cell + |
| CurationStatus | uncurated + |
| DefiningCitation | Winer et al, 1996 + |
| DefiningCriteria | large soma with dense VGLUT2+ endings + |
| Definition | Winer and colleagues (1996) first describe … Winer and colleagues (1996) first described that GABAergic neurons project to the medial geniculate body in cat. Peruzzi et al. (1997) showed that the cell type is also found in rats, and sends action potentials more rapidly than glutamatergic IC neurons. Ito and colleagues (2009) showed that the cell type is the largest neuron in the IC and receives dense VGLUT2-positive axosomatic terminals on the cell body. Other cell types such as glutamatergic neurons and small GABAergic neurons do not have such endings. ABAergic neurons do not have such endings. |
| DendriteLocation | Inferior colliculus + |
| Has default formThis property is a special property in this wiki. | Petilla neuron + |
| Has role | Principal neuron role + |
| Id | nlx_60854 + |
| Label | Colliculus Inferior GABAergic Principal Cell + |
| Located in | Inferior colliculus + |
| LocationOfAxonArborization | Medial geniculate body + |
| ModifiedDate | 3 April 2013 + |
| MolecularConstituents | Parvalbumin + |
| Neurotransmitter | GABA + |
| NeurotransmitterReceptors | Glutamate-gated cationic channel +, GABA-gated anionic channel +, and Glycine-gated chloride channel + |
| OriginOfAxon | soma + |
| PMID | 8755593 + |
| Page has default formThis property is a special property in this wiki. | Petilla neuron + |
| PublicationLink | http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&Cmd=Retrieve&list_uids=8755593 + |
| Species | Mammal + |
| SpineDensityOnDendrites | Smooth + |
| SubcellularSynapticTarget | dendrite + |
| SuperCategory | Neuron + |
| Synonym | large GABAergic (LG) neurons + |