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Colliculus Inferior GABAergic Principal Cell

Name: Colliculus Inferior GABAergic Principal Cell
Description: Winer and colleagues (1996) first described that GABAergic neurons project to the medial geniculate body in cat. Peruzzi et al. (1997) showed that the cell type is also found in rats, and sends action potentials more rapidly than glutamatergic IC neurons. Ito and colleagues (2009) showed that the cell type is the largest neuron in the IC and receives dense VGLUT2-positive axosomatic terminals on the cell body. Other cell types such as glutamatergic neurons and small GABAergic neurons do not have such endings.[1]
Synonym(s): large GABAergic (LG) neurons[1]
Has role: Principal neuron role[2]
Super-category: Neuron
URL: Winer et al, 1996
Id: nlx_60854
PMID: PMID 8755593
Publication link: http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&Cmd=Retrieve&list_uids=8755593
Defining criteria: large soma with dense VGLUT2+ endings[2]
Organism: Mammal
Link to OWL / RDF: Download this content as OWL/RDF

Soma Specific Properties

Cell Soma Shape: Multipolar[3]
Cell Soma Size: Large soma[2]
Soma Location: inferior colliculus[2]

Dendrite Specific Properties

Dendrite location: Inferior colliculus[2]
Spine density on dendrites: Smooth
Branching type: stellate

Axon Specific Properties

Axon myelination: myelinated[4]
Axon projection laterality: ipsilateral
Origin of axon: soma
Location of distant axon arborization: medial geniculate body

Intrinsic Properties

Neurotransmitter released: GABA[5]
Neurotransmitter receptors: Glutamate-gated cationic channel, GABA-gated anionic channel, Glycine-gated chloride channel
Molecular constituents: parvalbumin[6]
Defining Criteria: large soma with dense VGLUT2+ endings [2]


References

  1. 1.0 1.1 Ito T & Oliver DL (2012) The basic circuit of the IC: tectothalamic neurons with different patterns of synaptic organization send different messages to the thalamus. Front Neural Circuits 6: 48 PubMed
  2. 2.0 2.1 2.2 2.3 2.4 2.5 Ito T et al. (2009) Two classes of GABAergic neurons in the inferior colliculus. J Neurosci 29: 13860-9 PubMed
  3. Oliver DL et al. (1994) Morphology of GABAergic neurons in the inferior colliculus of the cat. J Comp Neurol 340: 27-42 PubMed
  4. 4.0 4.1 4.2 Saint Marie RL et al. (1997) Substrate for rapid feedforward inhibition of the auditory forebrain. Brain Res 765: 173-6 PubMed
  5. Winer JA et al. (1996) GABAergic feedforward projections from the inferior colliculus to the medial geniculate body. Proc Natl Acad Sci U S A 93: 8005-10 PubMed
  6. Fredrich M et al. (2009) Neuronal subtype identity in the rat auditory brainstem as defined by molecular profile and axonal projection. Exp Brain Res 195: 241-60 PubMed
  7. 7.0 7.1 Bartlett EL et al. (2000) Comparison of the fine structure of cortical and collicular terminals in the rat medial geniculate body. Neuroscience 100: 811-28 PubMed

Notes

This page uses this default form:Petilla_neuron



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Facts about Colliculus Inferior GABAergic Principal CellRDF feed
AxonDiameterMean: 1.63 micrometer  +
AxonMyelinationmyelinated  +
AxonProjectionLateralityipsilateral  +
AxonTractBrachium of the inferior colliculus  +
BranchingMetricsstellate  +
CellSomaShapeCategory:Multipolar   +
CellSomaSizeLarge soma  +
CellularSynapticTargetMedial geniculate body stellate cell  +
CurationStatusuncurated  +
DefiningCitationWiner et al, 1996  +
DefiningCriterialarge soma with dense VGLUT2+ endings  +
DefinitionWiner and colleagues (1996) first describe Winer and colleagues (1996) first described that GABAergic neurons project to the medial geniculate body in cat. Peruzzi et al. (1997) showed that the cell type is also found in rats, and sends action potentials more rapidly than glutamatergic IC neurons. Ito and colleagues (2009) showed that the cell type is the largest neuron in the IC and receives dense VGLUT2-positive axosomatic terminals on the cell body. Other cell types such as glutamatergic neurons and small GABAergic neurons do not have such endings. ABAergic neurons do not have such endings.
DendriteLocationInferior colliculus  +
Has default formThis property is a special property in this wiki.Petilla neuron  +
Has rolePrincipal neuron role  +
Idnlx_60854  +
LabelColliculus Inferior GABAergic Principal Cell  +
Located inInferior colliculus  +
LocationOfAxonArborizationMedial geniculate body  +
ModifiedDate3 April 2013  +
MolecularConstituentsParvalbumin  +
NeurotransmitterGABA  +
NeurotransmitterReceptorsGlutamate-gated cationic channel  +, GABA-gated anionic channel  +, and Glycine-gated chloride channel  +
OriginOfAxonsoma  +
PMID8755593  +
Page has default formThis property is a special property in this wiki.Petilla neuron  +
PublicationLinkhttp://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&Cmd=Retrieve&list_uids=8755593  +
SpeciesMammal  +
SpineDensityOnDendritesSmooth  +
SubcellularSynapticTargetdendrite  +
SuperCategoryNeuron  +
Synonymlarge GABAergic (LG) neurons  +