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D1 receptor

Name: D1 receptor
Description: Dopamine receptor that stimulates adenylyl cyclase activity, and has a high affinity for SKF 38393 and its homologs. It is a protien that is encoded, in humans, by the DRD1 gene. The D1 subtype is the most abundant dopamine receptor in the central nervous system. This G-protein coupled receptor stimulates adenylyl cyclase and activates cyclic AMP-dependent protein kinases. D1 receptors are enriched in Caudate-putamen, nucleus accumbens, and olfactory tubercles. These receptors regulate neuronal growth and development, mediate some behavioral responses, and modulate dopamine receptor D2-mediated events. Alternate transcription initiation sites result in two transcript variants of this gene. (adapted from Entrez Gene)
Synonym(s): D1; D(1A) dopamine receptor, DRD1, D1 dopamine receptor, dopamine D1 receptor
Abbreviation: D1R
Is part of: Catecholamine system, Dopaminergic system
Has role: Dopamine receptor, Neurotransmitter Receptor, G-protein coupled receptor
Super-category: Protein
URL: Entrez Gene
*Id: nifext_5845
PMID: PMID 215920
Related to: Dopamine, Schizophrenia, D5 receptor
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Categories related to D1 receptor

Acetophenazine, Amantadine, Apomorphine, Carphenazine, Chlorprothixene, Clozapine, Cocaine, D5 receptor, Dopamine, Fenoldopam, Flupenthixol, Fluphenazine, Haloperidol, Levodopa, Lisuride, Loxapine, Methylergonovine, Minaprine, Olanzapine, Pegademase bovine, Pergolide, Perphenazine, Prochlorperazine, Promazine, Propiomazine, Quetiapine, Thiethylperazine, Thioridazine, Triflupromazine, Zuclopenthixol




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*Note: Neurolex imports many terms and their ids from existing community ontologies, e.g., the Gene Ontology. Neurolex, however, is a dynamic site and any content beyond the identifier should not be presumed to reflect the content or views of the source ontology. Users should consult with the authoritative source for each ontology for current information.

Facts about D1 receptorRDF feed
AbbrevD1R  +
Created19 September 2007  +
CurationStatusuncurated  +
DefiningCitationEntrez Gene  +
DefinitionDopamine receptor that stimulates adenylyl Dopamine receptor that stimulates adenylyl cyclase activity, and has a high affinity for SKF 38393 and its homologs. It is a protien that is encoded, in humans, by the DRD1 gene. The D1 subtype is the most abundant dopamine receptor in the central nervous system. This G-protein coupled receptor stimulates adenylyl cyclase and activates cyclic AMP-dependent protein kinases. D1 receptors are enriched in Caudate-putamen, nucleus accumbens, and olfactory tubercles. These receptors regulate neuronal growth and development, mediate some behavioral responses, and modulate dopamine receptor D2-mediated events. Alternate transcription initiation sites result in two transcript variants of this gene. (adapted from Entrez Gene) s of this gene. (adapted from Entrez Gene)
Has roleDopamine receptor  +, Neurotransmitter Receptor  +, and G-protein coupled receptor  +
Idnifext_5845  +
Is part ofCatecholamine system  +, and Dopaminergic system  +
LabelD1 receptor  +
ModifiedDate20 June 2012  +
PMID215920  +
RelatedToDopamine  +, Schizophrenia  +, and D5 receptor  +
SuperCategoryProtein  +
SynonymD1; D(1A) dopamine receptor  +, DRD1  +, D1 dopamine receptor  +, and dopamine D1 receptor  +