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Dapsone

Name: Dapsone
Description: A sulfone active against a wide range of bacteria but mainly employed for its actions against mycobacterium leprae. Its mechanism of action is probably similar to that of the sulfonamides which involves inhibition of folic acid synthesis in susceptible organisms. It is also used with pyrimethamine in the treatment of malaria. (From Martindale, The Extra Pharmacopoeia, 30th ed, p157-8) Pharmacology: Dapsone is a sulfone with anti-inflammatory immunosuppressive properties as well as antibacterial and antibiotic properties. Dapsone is the principal drug in a multidrug regimen recommended by the World Health Organization for the treatment of leprosy. As an anti-infective agent, it is also used for treating malaria and, recently, for Pneumocystic carinii pneumonia in AIDS patients. Dapsone is absorbed rapidly and nearly completely from the gastrointestinal tract. Dapsone is distributed throughout total body water and is present in all tissues. However, it tends to be retained in skin and muscle and especially in the liver and kidney: traces of the drug are present in these organs up to 3 weeks after therapy cessation. Mechanism of action: Dapsone acts against bacteria and protozoa in the same way as sulphonamides, that is by inhibiting the synthesis of dihydrofolic acid through competition with para-amino-benzoate for the active site of dihydropteroate synthetase. The anti-inflammatory action of the drug is unrelated to its antibacterial action and is still not fully understood. Drug type: Approved. Investigational. Small Molecule. Drug category: Anti-Infective Agents. Anti-Infectives. Anti-inflammatory Agents. Antimalarials. Antimycobacterials. Folic Acid Antagonists. Leprostatic Agents
Synonym(s): Acedapsone, DADPS, DDS, DSS, Dapson, Dapsonum, Dds, Diaphenylsulfone, Dds, Pharmaceutical, Diamino-diphenyl sulphone, Diaminodifenilsulfona, Diaminodiphenyl Sulfone, Diaphenylsulfon, Diaphenylsulfone, Diaphenylsulphon, Diaphenylsulphone, Diphenasone, Metabolite C, N, N'-Diphenyl Sulfondiamide, P, P'-Sulfonyldianiline, P, P'-Diaminodiphenyl Sulfone, P, P-Diaminodiphenyl Sulphone, P, P-Sulfonylbisbenzamine, P, P-Sulfonylbisbenzenamine, P, P-Sulphonylbisbenzamine, P, P-Sulphonylbisbenzenamine, P, P-Sulphonyldianiline, P-Aminophenyl Sulfone, Sulfonyldianiline, Sulphadione, Sulphonyldianiline, dapsone, Araldite Ht, Avlosulfon, Avlosulfone, Avlosulphone, Croysulfone, Croysulphone, Dimitone, Diphone, Dubronax, Dumitone, Eporal, ICI, Normet, Novophone, Recolip, Sulfadione, Sulfanona-Mae, Sulfon-Mere, Sulfona, Sulfona-Mae, Sulfone Ucb, Sulphon-Mere, Sumicure S, Tarimyl, Udolac
Has role: Drug
Super-category: Molecular entity
URL: http://www.drugbank.ca/drugs/DB00250
*Id: DB00250
Related to: Dihydrofolate reductase, Dihydropteroate synthase 1, Dihydropteroate synthase 2
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Facts about DapsoneRDF feed
Commenttaken from DrugBank
CuratorAb  +
DefiningCitationhttp://www.drugbank.ca/drugs/DB00250  +
DefinitionA sulfone active against a wide range of b A sulfone active against a wide range of bacteria but mainly employed for its actions against mycobacterium leprae. Its mechanism of action is probably similar to that of the sulfonamides which involves inhibition of folic acid synthesis in susceptible organisms. It is also used with pyrimethamine in the treatment of malaria. (From Martindale, The Extra Pharmacopoeia, 30th ed, p157-8) Pharmacology: Dapsone is a sulfone with anti-inflammatory immunosuppressive properties as well as antibacterial and antibiotic properties. Dapsone is the principal drug in a multidrug regimen recommended by the World Health Organization for the treatment of leprosy. As an anti-infective agent, it is also used for treating malaria and, recently, for Pneumocystic carinii pneumonia in AIDS patients. Dapsone is absorbed rapidly and nearly completely from the gastrointestinal tract. Dapsone is distributed throughout total body water and is present in all tissues. However, it tends to be retained in skin and muscle and especially in the liver and kidney: traces of the drug are present in these organs up to 3 weeks after therapy cessation. Mechanism of action: Dapsone acts against bacteria and protozoa in the same way as sulphonamides, that is by inhibiting the synthesis of dihydrofolic acid through competition with para-amino-benzoate for the active site of dihydropteroate synthetase. The anti-inflammatory action of the drug is unrelated to its antibacterial action and is still not fully understood. Drug type: Approved. Investigational. Small Molecule. Drug category: Anti-Infective Agents. Anti-Infectives. Anti-inflammatory Agents. Antimalarials. Antimycobacterials. Folic Acid Antagonists. Leprostatic Agents Folic Acid Antagonists. Leprostatic Agents
Has roleDrug  +
IdDB00250  +
LabelDapsone  +
ModifiedDate14 April 2014  +
RelatedToDihydrofolate reductase  +, Dihydropteroate synthase 1  +, and Dihydropteroate synthase 2  +
SuperCategoryMolecular entity  +
SynonymAcedapsone  +, DADPS  +, DDS  +, DSS  +, Dapson  +, Dapsonum  +, Dds  +, Diaphenylsulfone  +, Pharmaceutical  +, Diamino-diphenyl sulphone  +, Diaminodifenilsulfona  +, Diaminodiphenyl Sulfone  +, Diaphenylsulfon  +, Diaphenylsulphon  +, Diaphenylsulphone  +, Diphenasone  +, Metabolite C  +, N  +, N'-Diphenyl Sulfondiamide  +, P  +, P'-Sulfonyldianiline  +, P'-Diaminodiphenyl Sulfone  +, P-Diaminodiphenyl Sulphone  +, P-Sulfonylbisbenzamine  +, P-Sulfonylbisbenzenamine  +, P-Sulphonylbisbenzamine  +, P-Sulphonylbisbenzenamine  +, P-Sulphonyldianiline  +, P-Aminophenyl Sulfone  +, Sulfonyldianiline  +, Sulphadione  +, Sulphonyldianiline  +, dapsone  +, Araldite Ht  +, Avlosulfon  +, Avlosulfone  +, Avlosulphone  +, Croysulfone  +, Croysulphone  +, Dimitone  +, Diphone  +, Dubronax  +, Dumitone  +, Eporal  +, ICI  +, Normet  +, Novophone  +, Recolip  +, Sulfadione  +, Sulfanona-Mae  +, Sulfon-Mere  +, Sulfona  +, Sulfona-Mae  +, Sulfone Ucb  +, Sulphon-Mere  +, Sumicure S  +, Tarimyl  +, and Udolac  +