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Dextromethorphan

Name: Dextromethorphan
Description: The d-isomer of the codeine analog of levorphanol. Dextromethorphan shows high affinity binding to several regions of the brain, including the medullary cough center. This compound is an NMDA receptor antagonist (receptors, N-methyl-D-aspartate) and acts as a non-competitive channel blocker. It is one of the widely used antitussives, and is also used to study the involvement of glutamate receptors in neurotoxicity. (PubChem) Pharmacology: Dextromethorphan suppresses the cough reflex by a direct action on the cough center in the medulla of the brain. Dextromethorphan shows high affinity binding to several regions of the brain, including the medullary cough center. This compound is an NMDA receptor antagonist and acts as a non-competitive channel blocker. It is one of the widely used antitussives, and is also used to study the involvement of glutamate receptors in neurotoxicity. Mechanism of action: Dextromethorphan is an opioid-like drug that binds to and acts as antagonist to the NMDA glutamatergic receptor, it is an agonist to the opioid sigma 1 and sigma 2 receptors, it is also an alpha3/beta4 nicotinic receptor antagonist and targets the serotonin reuptake pump. Dextromethorphan is rapidly absorbed from the gastrointestinal tract, where it enters the bloodstream and crosses the blood-brain barrier. The first-pass through the hepatic portal vein results in some of the drug being metabolized into an active metabolite of dextromethorphan, dextrorphan, the 3-hydroxy derivative of dextromethorphan. Drug type: Approved. Small Molecule. Drug category: Analgesics, Opioid. Antitussive Agents. Excitatory Amino Acid Antagonists
Synonym(s): D-Methorphan, D-Methorphan Hydrobromide, Delta-Methorphan, Demorphan, Demorphan Hydrobromide, Demorphine, Destrometerfano (Dcit), Dextromethorfan (Czech), Dextromethorphan Bromhydrate, Dextromethorphan Bromide, Dextrometorfano (INN-Spanish), Dextrometorphan, Dextromorphan, Dexyromethorphan, L-Methorphan, Levomethorphan, Levomethorphan (Ban:Dcf:Inn), Levomethorphane (INN-French), Levomethorphanum (INN-Latin), Levometorfano (INN-Spanish), Antussan, Balminil DM, Benylin DM, Calmylin, Canfodion, Cosylan, Creo-Terpin, Delsym, Dormetan, Dormethan, Hihustan M, Koffex DM, Medicon, Methorate Hydrobromide, Methorphan, Metrorat, Novahistex DM, Novahistine DM, Pertussin, Pertussin DM, Robitussin, Romilar, Triaminic DM, Trocal, Tusilan, Tussade, Vicks 44
Abbreviation: DM
Has role: Drug, Drug of abuse role, Antagonist role
Super-category: Molecular entity
URL: http://www.drugbank.ca/drugs/DB00514
*Id: CHEBI:4470
Related to: Cholinergic system, Sigma 1-type opioid receptor, Opioid receptor, sigma 1, Glutamate (NMDA) receptor subunit 3A, Neuronal acetylcholine receptor subunit alpha-2, Sodium-dependent serotonin transporter, Alpha 3 Acetylcholine Receptor
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Categories related to Dextromethorphan

Alpha 3 Acetylcholine Receptor


street names: Cough-X, Hold DM,



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Facts about DextromethorphanRDF feed
AbbrevDM  +
Commenttaken from DrugBank
CurationStatusuncurated  +
CuratorAb  +
DefiningCitationhttp://www.drugbank.ca/drugs/DB00514  +
DefinitionThe d-isomer of the codeine analog of levo The d-isomer of the codeine analog of levorphanol. Dextromethorphan shows high affinity binding to several regions of the brain, including the medullary cough center. This compound is an NMDA receptor antagonist (receptors, N-methyl-D-aspartate) and acts as a non-competitive channel blocker. It is one of the widely used antitussives, and is also used to study the involvement of glutamate receptors in neurotoxicity. (PubChem) Pharmacology: Dextromethorphan suppresses the cough reflex by a direct action on the cough center in the medulla of the brain. Dextromethorphan shows high affinity binding to several regions of the brain, including the medullary cough center. This compound is an NMDA receptor antagonist and acts as a non-competitive channel blocker. It is one of the widely used antitussives, and is also used to study the involvement of glutamate receptors in neurotoxicity. Mechanism of action: Dextromethorphan is an opioid-like drug that binds to and acts as antagonist to the NMDA glutamatergic receptor, it is an agonist to the opioid sigma 1 and sigma 2 receptors, it is also an alpha3/beta4 nicotinic receptor antagonist and targets the serotonin reuptake pump. Dextromethorphan is rapidly absorbed from the gastrointestinal tract, where it enters the bloodstream and crosses the blood-brain barrier. The first-pass through the hepatic portal vein results in some of the drug being metabolized into an active metabolite of dextromethorphan, dextrorphan, the 3-hydroxy derivative of dextromethorphan. Drug type: Approved. Small Molecule. Drug category: Analgesics, Opioid. Antitussive Agents. Excitatory Amino Acid Antagonists Agents. Excitatory Amino Acid Antagonists
Has roleDrug  +, Drug of abuse role  +, and Antagonist role  +
IdCHEBI:4470  +
LabelDextromethorphan  +
ModifiedDate12 August 2014  +
RelatedToCholinergic system  +, Sigma 1-type opioid receptor  +, Opioid receptor  +, Sigma 1  +, Glutamate (NMDA) receptor subunit 3A  +, Neuronal acetylcholine receptor subunit alpha-2  +, Sodium-dependent serotonin transporter  +, and Alpha 3 Acetylcholine Receptor  +
SuperCategoryMolecular entity  +
SynonymD-Methorphan  +, D-Methorphan Hydrobromide  +, Delta-Methorphan  +, Demorphan  +, Demorphan Hydrobromide  +, Demorphine  +, Destrometerfano (Dcit)  +, Dextromethorfan (Czech)  +, Dextromethorphan Bromhydrate  +, Dextromethorphan Bromide  +, Dextrometorfano (INN-Spanish)  +, Dextrometorphan  +, Dextromorphan  +, Dexyromethorphan  +, L-Methorphan  +, Levomethorphan  +, Levomethorphan (Ban:Dcf:Inn)  +, Levomethorphane (INN-French)  +, Levomethorphanum (INN-Latin)  +, Levometorfano (INN-Spanish)  +, Antussan  +, Balminil DM  +, Benylin DM  +, Calmylin  +, Canfodion  +, Cosylan  +, Creo-Terpin  +, Delsym  +, Dormetan  +, Dormethan  +, Hihustan M  +, Koffex DM  +, Medicon  +, Methorate Hydrobromide  +, Methorphan  +, Metrorat  +, Novahistex DM  +, Novahistine DM  +, Pertussin  +, Pertussin DM  +, Robitussin  +, Romilar  +, Triaminic DM  +, Trocal  +, Tusilan  +, Tussade  +, and Vicks 44  +