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Dihydroergotamine
| Name: | Dihydroergotamine |
| Description: | A 9,10alpha-dihydro derivative of ergotamine. It is used as a vasoconstrictor, specifically for the therapy of migraine disorders. (PubChem) Pharmacology: Dihydroergotamine is indicated for the acute treatment of migraine headaches with or without aura and the acute treatment of cluster headache episodes. Dihydroergotamine binds with high affinity to 5-HT1Da and 5-HT1Db receptors. It also binds with high affinity to serotonin 5-HT1A, 5-HT2A, and 5-HT2C receptors, noradrenaline a2A, a2B and a receptors, and dopamine D2L and D3 receptors. The therapeutic activity of Dihydroergotamine in migraine is generally attributed to the agonist effect at 5-HT1D receptors. Mechanism of action: Two theories have been proposed to explain the efficacy of 5-HT1D receptor agonists in migraine: 1) activation of 5-HT1D receptors located on intracranial blood vessels, including those on arterio-venous anastomoses, leads to vasoconstriction, which correlates with the relief of migraine headache and 2) activation of 5-HT1D receptors on sensory nerve endings of the trigeminal system results in the inhibition of pro-inflammatory neuropeptide release. Drug type: Approved. Small Molecule. Drug category: Analgesics. Analgesics, Non-Narcotic. Anti-migraine Agents. Dopamine Agonists. Sympatholytics. Vasoconstrictor Agents |
| Synonym(s): | 9, 10-dihydro-ergotamine, Dihidroergotamina (INN-Spanish), Dihydroergotamine mesylate, Dihydroergotamine methanesulfonate, Dihydroergotamine monomethanesulfonate, Dihydroergotaminum (INN-Latin), Agit, Angionorm, D, H, E, D, H, E, 45, DET MS, DHE-45, Dergotamine, Diergo, Dihydergot, Dirgotarl, Endophleban, Ergomimet, Ergont, Ergotonin, Ikaran, Migranal, Morena, Orstanorm, Tonopres, Verladyn |
| Related to: | 5-hydroxytryptamine 2A receptor, 5-hydroxytryptamine 1D receptor, 5-hydroxytryptamine 1B receptor |
| Has role: | Drug |
| Super-category: | Molecule |
| URL: | http://www.drugbank.ca/drugs/DB00320 |
| Id: | DB00320 |
| Link to OWL / RDF: | Download this content as OWL/RDF |
Facts about DihydroergotamineRDF feed
| Comment | taken from DrugBank |
| Curator | Ab + |
| DefiningCitation | http://www.drugbank.ca/drugs/DB00320 + |
| Definition | A 9,10alpha-dihydro derivative of ergotami … A 9,10alpha-dihydro derivative of ergotamine. It is used as a vasoconstrictor, specifically for the therapy of migraine disorders. (PubChem) Pharmacology: Dihydroergotamine is indicated for the acute treatment of migraine headaches with or without aura and the acute treatment of cluster headache episodes. Dihydroergotamine binds with high affinity to 5-HT1Da and 5-HT1Db receptors. It also binds with high affinity to serotonin 5-HT1A, 5-HT2A, and 5-HT2C receptors, noradrenaline a2A, a2B and a receptors, and dopamine D2L and D3 receptors. The therapeutic activity of Dihydroergotamine in migraine is generally attributed to the agonist effect at 5-HT1D receptors. Mechanism of action: Two theories have been proposed to explain the efficacy of 5-HT1D receptor agonists in migraine: 1) activation of 5-HT1D receptors located on intracranial blood vessels, including those on arterio-venous anastomoses, leads to vasoconstriction, which correlates with the relief of migraine headache and 2) activation of 5-HT1D receptors on sensory nerve endings of the trigeminal system results in the inhibition of pro-inflammatory neuropeptide release. Drug type: Approved. Small Molecule. Drug category: Analgesics. Analgesics, Non-Narcotic. Anti-migraine Agents. Dopamine Agonists. Sympatholytics. Vasoconstrictor Agents ts. Sympatholytics. Vasoconstrictor Agents |
| Has role | Drug + |
| Id | DB00320 + |
| Label | Dihydroergotamine + |
| ModifiedDate | 4 February 2010 + |
| RelatedTo | 5-hydroxytryptamine 2A receptor +, 5-hydroxytryptamine 1D receptor +, and 5-hydroxytryptamine 1B receptor + |
| SuperCategory | Molecule + |
| Synonym | 9 +, 10-dihydro-ergotamine +, Dihidroergotamina (INN-Spanish) +, Dihydroergotamine mesylate +, Dihydroergotamine methanesulfonate +, Dihydroergotamine monomethanesulfonate +, Dihydroergotaminum (INN-Latin) +, Agit +, Angionorm +, D +, H +, E +, 45 +, DET MS +, DHE-45 +, Dergotamine +, Diergo +, Dihydergot +, Dirgotarl +, Endophleban +, Ergomimet +, Ergont +, Ergotonin +, Ikaran +, Migranal +, Morena +, Orstanorm +, Tonopres +, and Verladyn + |