EditFrom NeuroLex
Dipyridamole
| Name: | Dipyridamole |
| Description: | A phosphodiesterase inhibitor that blocks uptake and metabolism of adenosine by erythrocytes and vascular endothelial cells. Dipyridamole also potentiates the antiaggregating action of prostacyclin. (From AMA Drug Evaluations Annual, 1994, p752) Pharmacology: Dipyridamole, a non-nitrate coronary vasodilator that also inhibits platelet aggregation, is combined with other anticoagulant drugs, such as warfarin, to prevent thrombosis in patients with valvular or vascular disorders. Dipyridamole is also used in myocardial perfusion imaging, as an antiplatelet agent, and in combination with aspirin for stroke prophylaxis. Mechanism of action: Dipyridamole likely inhibits both adenosine deaminase and phosphodiesterase, preventing the degradation of cAMP, an inhibitor of platelet function. This elevation in cAMP blocks the release of arachidonic acid from membrane phospholipids and reduces thromboxane A2 activity. Dipyridamole also directly stimulates the release of prostacyclin, which induces adenylate cyclase activity, thereby raising the intraplatelet concentration of cAMP and further inhibiting platelet aggregation. Drug type: Approved. Small Molecule. Drug category: Phosphodiesterase Inhibitors. Platelet Aggregation Inhibitors. Vasodilator Agents |
| Synonym(s): | Dipiridamol, Dipyridamine, Dipyridamol, Dipyudamine, Dypyridamol, Usaf Ge-12, Aggrenox, Agilease, Anginal, Apo-Dipyridamole Fc, Apo-Dipyridamole Sc, Apricor, Cardioflux, Cardoxil, Chilcolan, Cleridium, Cleridium 150, Coribon, Coridil, Coronarine, Corosan, Coroxin, Curantyl, Dipyridan, Gulliostin, IV Persantine, Justpertin, Kurantil, Natyl, Novo-Dipiradol, Peridamol, Permiltin, Persantin, Persantine, Piroan, Prandiol, Prandiol 75, Protangix, RA 8, RA-8, Stenocardil, Stenocardiol, Stimolcardio |
| Related to: | cGMP-specific 3', 5'-cyclic phosphodiesterase, cAMP and cAMP-inhibited cGMP 3', 5'-cyclic phosphodiesterase 10A, Multidrug resistance protein 1, cAMP-specific 3', 5'-cyclic phosphodiesterase 4A, Adenosine deaminase |
| Has role: | Drug |
| Super-category: | Molecule |
| URL: | http://www.drugbank.ca/drugs/DB00975 |
| Id: | CHEBI_4653 |
| Link to OWL / RDF: | Download this content as OWL/RDF |
Facts about DipyridamoleRDF feed
| Comment | taken from DrugBank |
| CurationStatus | uncurated + |
| Curator | Ab + |
| DefiningCitation | http://www.drugbank.ca/drugs/DB00975 + |
| Definition | A phosphodiesterase inhibitor that blocks … A phosphodiesterase inhibitor that blocks uptake and metabolism of adenosine by erythrocytes and vascular endothelial cells. Dipyridamole also potentiates the antiaggregating action of prostacyclin. (From AMA Drug Evaluations Annual, 1994, p752) Pharmacology: Dipyridamole, a non-nitrate coronary vasodilator that also inhibits platelet aggregation, is combined with other anticoagulant drugs, such as warfarin, to prevent thrombosis in patients with valvular or vascular disorders. Dipyridamole is also used in myocardial perfusion imaging, as an antiplatelet agent, and in combination with aspirin for stroke prophylaxis. Mechanism of action: Dipyridamole likely inhibits both adenosine deaminase and phosphodiesterase, preventing the degradation of cAMP, an inhibitor of platelet function. This elevation in cAMP blocks the release of arachidonic acid from membrane phospholipids and reduces thromboxane A2 activity. Dipyridamole also directly stimulates the release of prostacyclin, which induces adenylate cyclase activity, thereby raising the intraplatelet concentration of cAMP and further inhibiting platelet aggregation. Drug type: Approved. Small Molecule. Drug category: Phosphodiesterase Inhibitors. Platelet Aggregation Inhibitors. Vasodilator Agents Aggregation Inhibitors. Vasodilator Agents |
| Has role | Drug + |
| Id | CHEBI_4653 + |
| Label | Dipyridamole + |
| ModifiedDate | 16 November 2010 + |
| RelatedTo | CGMP-specific 3' +, 5'-cyclic phosphodiesterase +, CAMP and cAMP-inhibited cGMP 3' +, 5'-cyclic phosphodiesterase 10A +, Multidrug resistance protein 1 +, CAMP-specific 3' +, 5'-cyclic phosphodiesterase 4A +, and Adenosine deaminase + |
| SuperCategory | Molecule + |
| Synonym | Dipiridamol +, Dipyridamine +, Dipyridamol +, Dipyudamine +, Dypyridamol +, Usaf Ge-12 +, Aggrenox +, Agilease +, Anginal +, Apo-Dipyridamole Fc +, Apo-Dipyridamole Sc +, Apricor +, Cardioflux +, Cardoxil +, Chilcolan +, Cleridium +, Cleridium 150 +, Coribon +, Coridil +, Coronarine +, Corosan +, Coroxin +, Curantyl +, Dipyridan +, Gulliostin +, IV Persantine +, Justpertin +, Kurantil +, Natyl +, Novo-Dipiradol +, Peridamol +, Permiltin +, Persantin +, Persantine +, Piroan +, Prandiol +, Prandiol 75 +, Protangix +, RA 8 +, RA-8 +, Stenocardil +, Stenocardiol +, and Stimolcardio + |