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Dipyridamole

Name: Dipyridamole
Description: A phosphodiesterase inhibitor that blocks uptake and metabolism of adenosine by erythrocytes and vascular endothelial cells. Dipyridamole also potentiates the antiaggregating action of prostacyclin. (From AMA Drug Evaluations Annual, 1994, p752) Pharmacology: Dipyridamole, a non-nitrate coronary vasodilator that also inhibits platelet aggregation, is combined with other anticoagulant drugs, such as warfarin, to prevent thrombosis in patients with valvular or vascular disorders. Dipyridamole is also used in myocardial perfusion imaging, as an antiplatelet agent, and in combination with aspirin for stroke prophylaxis. Mechanism of action: Dipyridamole likely inhibits both adenosine deaminase and phosphodiesterase, preventing the degradation of cAMP, an inhibitor of platelet function. This elevation in cAMP blocks the release of arachidonic acid from membrane phospholipids and reduces thromboxane A2 activity. Dipyridamole also directly stimulates the release of prostacyclin, which induces adenylate cyclase activity, thereby raising the intraplatelet concentration of cAMP and further inhibiting platelet aggregation. Drug type: Approved. Small Molecule. Drug category: Phosphodiesterase Inhibitors. Platelet Aggregation Inhibitors. Vasodilator Agents
Synonym(s): Dipiridamol, Dipyridamine, Dipyridamol, Dipyudamine, Dypyridamol, Usaf Ge-12, Aggrenox, Agilease, Anginal, Apo-Dipyridamole Fc, Apo-Dipyridamole Sc, Apricor, Cardioflux, Cardoxil, Chilcolan, Cleridium, Cleridium 150, Coribon, Coridil, Coronarine, Corosan, Coroxin, Curantyl, Dipyridan, Gulliostin, IV Persantine, Justpertin, Kurantil, Natyl, Novo-Dipiradol, Peridamol, Permiltin, Persantin, Persantine, Piroan, Prandiol, Prandiol 75, Protangix, RA 8, RA-8, Stenocardil, Stenocardiol, Stimolcardio
Has role: Drug
Super-category: Molecular entity
URL: http://www.drugbank.ca/drugs/DB00975
Id: CHEBI:4653
Related to: cGMP-specific 3', 5'-cyclic phosphodiesterase, cAMP and cAMP-inhibited cGMP 3', 5'-cyclic phosphodiesterase 10A, Multidrug resistance protein 1, cAMP-specific 3', 5'-cyclic phosphodiesterase 4A, Adenosine deaminase
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Commenttaken from DrugBank
CurationStatusuncurated  +
CuratorAb  +
DefiningCitationhttp://www.drugbank.ca/drugs/DB00975  +
DefinitionA phosphodiesterase inhibitor that blocks A phosphodiesterase inhibitor that blocks uptake and metabolism of adenosine by erythrocytes and vascular endothelial cells. Dipyridamole also potentiates the antiaggregating action of prostacyclin. (From AMA Drug Evaluations Annual, 1994, p752) Pharmacology: Dipyridamole, a non-nitrate coronary vasodilator that also inhibits platelet aggregation, is combined with other anticoagulant drugs, such as warfarin, to prevent thrombosis in patients with valvular or vascular disorders. Dipyridamole is also used in myocardial perfusion imaging, as an antiplatelet agent, and in combination with aspirin for stroke prophylaxis. Mechanism of action: Dipyridamole likely inhibits both adenosine deaminase and phosphodiesterase, preventing the degradation of cAMP, an inhibitor of platelet function. This elevation in cAMP blocks the release of arachidonic acid from membrane phospholipids and reduces thromboxane A2 activity. Dipyridamole also directly stimulates the release of prostacyclin, which induces adenylate cyclase activity, thereby raising the intraplatelet concentration of cAMP and further inhibiting platelet aggregation. Drug type: Approved. Small Molecule. Drug category: Phosphodiesterase Inhibitors. Platelet Aggregation Inhibitors. Vasodilator Agents Aggregation Inhibitors. Vasodilator Agents
Has roleDrug  +
IdCHEBI:4653  +
LabelDipyridamole  +
ModifiedDate12 August 2014  +
RelatedToCGMP-specific 3'  +, 5'-cyclic phosphodiesterase  +, CAMP and cAMP-inhibited cGMP 3'  +, 5'-cyclic phosphodiesterase 10A  +, Multidrug resistance protein 1  +, CAMP-specific 3'  +, 5'-cyclic phosphodiesterase 4A  +, and Adenosine deaminase  +
SuperCategoryMolecular entity  +
SynonymDipiridamol  +, Dipyridamine  +, Dipyridamol  +, Dipyudamine  +, Dypyridamol  +, Usaf Ge-12  +, Aggrenox  +, Agilease  +, Anginal  +, Apo-Dipyridamole Fc  +, Apo-Dipyridamole Sc  +, Apricor  +, Cardioflux  +, Cardoxil  +, Chilcolan  +, Cleridium  +, Cleridium 150  +, Coribon  +, Coridil  +, Coronarine  +, Corosan  +, Coroxin  +, Curantyl  +, Dipyridan  +, Gulliostin  +, IV Persantine  +, Justpertin  +, Kurantil  +, Natyl  +, Novo-Dipiradol  +, Peridamol  +, Permiltin  +, Persantin  +, Persantine  +, Piroan  +, Prandiol  +, Prandiol 75  +, Protangix  +, RA 8  +, RA-8  +, Stenocardil  +, Stenocardiol  +, and Stimolcardio  +