EditFrom NeuroLex
Dobutamine
| Name: | Dobutamine |
| Description: | A beta-2 agonist catecholamine that has cardiac stimulant action without evoking vasoconstriction or tachycardia. It is proposed as a cardiotonic after myocardial infarction or open heart surgery. (PubChem) Pharmacology: Dobutamine is a direct-acting inotropic agent whose primary activity results from stimulation of the beta-adrenoceptors of the heart while producing comparatively mild chronotropic, hypertensive, arrhythmogenic, and vasodilative effects. Dobutamine acts primarily on beta-1 adrenergic receptors, with little effect on beta-2 or alpha receptors. It does not cause the release of endogenous norepinephrine, as does dopamine. Dobutamine is indicated when parenteral therapy is necessary for inotropic support in the short-term treatment of patients with cardiac decompensation due to depressed contractility resulting either from organic heart disease or from cardiac surgical procedures. Mechanism of action: Dobutamine directly stimulates beta-1 receptors of the heart to increase myocardial contractility and stroke volume, resulting in increased cardiac output. Drug type: Approved. Small Molecule. Drug category: Adrenergic beta-Agonists. Cardiotonic Agents. Sympathomimetic. Sympathomimetics |
| Synonym(s): | Dobutamina (INN-Spanish), Dobutamine Hcl, Dobutamine Hcl in Dextrose 5%, Dobutamine Hydrochloride, Dobutamine (Usan:Ban:Inn), Dobutamine (Usan), Dobutaminum (INN-Latin), Dobutrex, Inotrex, Racemic-Dobutamine |
| Related to: | Beta-1 adrenergic receptor |
| Has role: | Drug |
| Super-category: | Molecule |
| URL: | http://www.drugbank.ca/drugs/DB00841 |
| Id: | DB00841 |
| Link to OWL / RDF: | Download this content as OWL/RDF |
Facts about DobutamineRDF feed
| Comment | taken from DrugBank |
| Curator | Ab + |
| DefiningCitation | http://www.drugbank.ca/drugs/DB00841 + |
| Definition | A beta-2 agonist catecholamine that has ca … A beta-2 agonist catecholamine that has cardiac stimulant action without evoking vasoconstriction or tachycardia. It is proposed as a cardiotonic after myocardial infarction or open heart surgery. (PubChem) Pharmacology: Dobutamine is a direct-acting inotropic agent whose primary activity results from stimulation of the beta-adrenoceptors of the heart while producing comparatively mild chronotropic, hypertensive, arrhythmogenic, and vasodilative effects. Dobutamine acts primarily on beta-1 adrenergic receptors, with little effect on beta-2 or alpha receptors. It does not cause the release of endogenous norepinephrine, as does dopamine. Dobutamine is indicated when parenteral therapy is necessary for inotropic support in the short-term treatment of patients with cardiac decompensation due to depressed contractility resulting either from organic heart disease or from cardiac surgical procedures. Mechanism of action: Dobutamine directly stimulates beta-1 receptors of the heart to increase myocardial contractility and stroke volume, resulting in increased cardiac output. Drug type: Approved. Small Molecule. Drug category: Adrenergic beta-Agonists. Cardiotonic Agents. Sympathomimetic. Sympathomimetics Agents. Sympathomimetic. Sympathomimetics |
| Has role | Drug + |
| Id | DB00841 + |
| Label | Dobutamine + |
| ModifiedDate | 4 February 2010 + |
| RelatedTo | Beta-1 adrenergic receptor + |
| SuperCategory | Molecule + |
| Synonym | Dobutamina (INN-Spanish) +, Dobutamine Hcl +, Dobutamine Hcl in Dextrose 5% +, Dobutamine Hydrochloride +, Dobutamine (Usan:Ban:Inn) +, Dobutamine (Usan) +, Dobutaminum (INN-Latin) +, Dobutrex +, Inotrex +, and Racemic-Dobutamine + |