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Dobutamine

Name: Dobutamine
Description: A beta-2 agonist catecholamine that has cardiac stimulant action without evoking vasoconstriction or tachycardia. It is proposed as a cardiotonic after myocardial infarction or open heart surgery. (PubChem) Pharmacology: Dobutamine is a direct-acting inotropic agent whose primary activity results from stimulation of the beta-adrenoceptors of the heart while producing comparatively mild chronotropic, hypertensive, arrhythmogenic, and vasodilative effects. Dobutamine acts primarily on beta-1 adrenergic receptors, with little effect on beta-2 or alpha receptors. It does not cause the release of endogenous norepinephrine, as does dopamine. Dobutamine is indicated when parenteral therapy is necessary for inotropic support in the short-term treatment of patients with cardiac decompensation due to depressed contractility resulting either from organic heart disease or from cardiac surgical procedures. Mechanism of action: Dobutamine directly stimulates beta-1 receptors of the heart to increase myocardial contractility and stroke volume, resulting in increased cardiac output. Drug type: Approved. Small Molecule. Drug category: Adrenergic beta-Agonists. Cardiotonic Agents. Sympathomimetic. Sympathomimetics
Synonym(s): Dobutamina (INN-Spanish), Dobutamine Hcl, Dobutamine Hcl in Dextrose 5%, Dobutamine Hydrochloride, Dobutamine (Usan:Ban:Inn), Dobutamine (Usan), Dobutaminum (INN-Latin), Dobutrex, Inotrex, Racemic-Dobutamine
Related to: Beta-1 adrenergic receptor
Has role: Drug
Super-category: Molecular entity
URL: http://www.drugbank.ca/drugs/DB00841
Id: DB00841
Link to OWL / RDF: Download this content as OWL/RDF


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Commenttaken from DrugBank
CuratorAb  +
DefiningCitationhttp://www.drugbank.ca/drugs/DB00841  +
DefinitionA beta-2 agonist catecholamine that has ca A beta-2 agonist catecholamine that has cardiac stimulant action without evoking vasoconstriction or tachycardia. It is proposed as a cardiotonic after myocardial infarction or open heart surgery. (PubChem) Pharmacology: Dobutamine is a direct-acting inotropic agent whose primary activity results from stimulation of the beta-adrenoceptors of the heart while producing comparatively mild chronotropic, hypertensive, arrhythmogenic, and vasodilative effects. Dobutamine acts primarily on beta-1 adrenergic receptors, with little effect on beta-2 or alpha receptors. It does not cause the release of endogenous norepinephrine, as does dopamine. Dobutamine is indicated when parenteral therapy is necessary for inotropic support in the short-term treatment of patients with cardiac decompensation due to depressed contractility resulting either from organic heart disease or from cardiac surgical procedures. Mechanism of action: Dobutamine directly stimulates beta-1 receptors of the heart to increase myocardial contractility and stroke volume, resulting in increased cardiac output. Drug type: Approved. Small Molecule. Drug category: Adrenergic beta-Agonists. Cardiotonic Agents. Sympathomimetic. Sympathomimetics Agents. Sympathomimetic. Sympathomimetics
Has roleDrug  +
IdDB00841  +
LabelDobutamine  +
ModifiedDate14 April 2014  +
RelatedToBeta-1 adrenergic receptor  +
SuperCategoryMolecular entity  +
SynonymDobutamina (INN-Spanish)  +, Dobutamine Hcl  +, Dobutamine Hcl in Dextrose 5%  +, Dobutamine Hydrochloride  +, Dobutamine (Usan:Ban:Inn)  +, Dobutamine (Usan)  +, Dobutaminum (INN-Latin)  +, Dobutrex  +, Inotrex  +, and Racemic-Dobutamine  +