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Domperidone

Name: Domperidone
Description: A specific blocker of dopamine receptors. It speeds gastrointestinal peristalsis, causes prolactin release, and is used as antiemetic and tool in the study of dopaminergic mechanisms. (PubChem) Pharmacology: Domperidone is a specific blocker of dopamine receptors. It speeds gastrointestinal peristalsis, causes prolactin release, and is used as antiemetic and tool in the study of dopaminergic mechanisms. Mechanism of action: Gastrointestinal emptying (delayed) adjunct; peristaltic stimulant: The gastroprokinetic properties of domperidone are related to its peripheral dopamine receptor blocking properties. Domperidone facilitates gastric emptying and decreases small bowel transit time by increasing esophageal and gastric peristalsis and by lowering esophageal sphincter pressure. Antiemetic: The antiemetic properties of domperidone are related to its dopamine receptor blocking activity at both the chemoreceptor trigger zone and at the gastric level. Drug type: Approved. Small Molecule. Drug category: Antiemetics. Dopamine Antagonists
Synonym(s): Lopac-D-122, Motilium, Nauzelin
Has role: Drug
Super-category: Molecular entity
URL: http://www.drugbank.ca/drugs/DB01184
*Id: DB01184
Related to: D(2) dopamine receptor
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Facts about DomperidoneRDF feed
Commenttaken from DrugBank
CuratorAb  +
DefiningCitationhttp://www.drugbank.ca/drugs/DB01184  +
DefinitionA specific blocker of dopamine receptors. A specific blocker of dopamine receptors. It speeds gastrointestinal peristalsis, causes prolactin release, and is used as antiemetic and tool in the study of dopaminergic mechanisms. (PubChem) Pharmacology: Domperidone is a specific blocker of dopamine receptors. It speeds gastrointestinal peristalsis, causes prolactin release, and is used as antiemetic and tool in the study of dopaminergic mechanisms. Mechanism of action: Gastrointestinal emptying (delayed) adjunct; peristaltic stimulant: The gastroprokinetic properties of domperidone are related to its peripheral dopamine receptor blocking properties. Domperidone facilitates gastric emptying and decreases small bowel transit time by increasing esophageal and gastric peristalsis and by lowering esophageal sphincter pressure. Antiemetic: The antiemetic properties of domperidone are related to its dopamine receptor blocking activity at both the chemoreceptor trigger zone and at the gastric level. Drug type: Approved. Small Molecule. Drug category: Antiemetics. Dopamine Antagonists ategory: Antiemetics. Dopamine Antagonists
Has roleDrug  +
IdDB01184  +
LabelDomperidone  +
ModifiedDate14 April 2014  +
RelatedToD(2) dopamine receptor  +
SuperCategoryMolecular entity  +
SynonymLopac-D-122  +, Motilium  +, and Nauzelin  +