From NeuroLex
Drug of abuse
| Name: | Drug of abuse |
| Description: | Any substance that is defined by the national institutes of drug abuse as being an abused drug. |
| Synonym(s): | abused drug, illegal drug, illicit drug |
| Super-category: | Defined class |
| Id: | nlx_chem_1003011 |
| Link to OWL / RDF: | Download this content as OWL/RDF |
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| Label | Id | Synonym | Definition | Has role | |
|---|---|---|---|---|---|
| Alkyl nitrite | Alkyl nitrite | nlx_chem_100301 | With a long history of safe medical use in treating angina, as well as an antidote to cyanide poisoning, several alkyl nitrites which are used in over-the-counter products, such as air fresheners and video head cleaners, are often inhaled with the goal of enhancing sexual pleasure and have also been part of the club culture from the 1970s disco scene to the 1980s and 1990s rave scene. (Adapted from Wikipedia) | Drug of abuse role Inhalant Drug |
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| Alprazolam | Alprazolam | CHEBI_2611 | TUS-1 alprazolam Alplax Alpronax Alviz Bestrol Cassadan Constan D 65MT Esparon Frontal Intensol Niravam Restyl Solanax Tafil Tranax Trankimazin Tranquinal Xanax Xanax XR Xanor |
A triazolobenzodiazepine compound with antianxiety and sedative-hypnotic actions, that is efficacious in the treatment of panic disorders, with or without agoraphobia, and in generalized anxiety disorders. (From AMA Drug Evaluations Annual, 1994, p238) Pharmacology: Alprazolam, a benzodiazepine, is used to treat panic disorder and anxiety disorder. Unlike chlordiazepoxide, clorazepate, and prazepam, alprazolam has a shorter half-life and metabolites with minimal activity. Like other triazolo benzodiazepines such as triazolam, alprazolam may have significant drug interactions involving the hepatic cytochrome P-450 3A4 isoenzyme. Clinically, all benzodiazepines cause a dose-related central nervous system depressant activity varying from mild impairment of task performance to hypnosis. Unlike other benzodiazepines, alprazolam may also have some antidepressant activity, although clinical evidence of this is lacking. Mechanism of action: Benzodiazepines bind nonspecifically to benzodiazepine receptors BNZ1, which mediates sleep, and BNZ2, which affects muscle relaxation, anticonvulsant activity, motor coordination, and memory. As benzodiazepine receptors are thought to be coupled to gamma-aminobutyric acid-A (GABAA) receptors, this enhances the effects of GABA by increasing GABA affinity for the GABA receptor. Binding of the inhibitory neurotransmitter GABA to the site opens the chloride channel, resulting in a hyperpolarized cell membrane that prevents further excitation of the cell. Drug type: Approved. Illicit. Investigational. Small Molecule. Drug category: Anti-anxiety Agents. Benzodiazepines. GABA Modulators. Hypnotics and Sedatives | Drug Drug of abuse role |
| Amobarbital | Amobarbital | CHEBI_2673 | Isomytal Amytal amylobarbitone Amytal sodium |
A barbiturate with hypnotic and sedative properties (but not antianxiety). Adverse effects are mainly a consequence of dose-related CNS depression and the risk of dependence with continued use is high. (From Martindale, The Extra Pharmacopoeia, 30th ed, p565) Pharmacology: Not Available Mechanism of action: Amobarbital (like all barbiturates) works by binding to the GABAA receptor at either the alpha or the beta sub unit. These are binding sites that are distinct from GABA itself and also distinct from the benzodiazepine binding site. Like benzodiazepines, barbiturates potentiate the effect of GABA at this receptor. This GABAA receptor binding decreases input resistance, depresses burst and tonic firing, especially in ventrobasal and intralaminar neurons, while at the same time increasing burst duration and mean conductance at individual chloride channels; this increases both the amplitude and decay time of inhibitory postsynaptic currents. In addition to this GABA-ergic effect, barbiturates also block the AMPA receptor, a subtype of glutamate receptor. Glutamate is the principal excitatory neurotransmitter in the mammalian CNS. Amobarbital also appears to bind neuronal nicotinic acetylcholine receptors. Drug type: Approved. Illicit. Small Molecule. Drug category: GABA Modulators. Hypnotics and Sedatives | Drug Drug of abuse role |
| Amyl Nitrite | Amyl Nitrite | CHEBI_2691 | 3-Methylbutanol nitrite 3-Methylbutyl nitrite Amilnitrit Amilnitrite Amyl nitrit Amyl nitrite I Amyl nitrosum IPN Isoamyl nitrite Isopentyl nitrite Nitramyl 3-methylbutyl ester Nitrous acid isopentyl ester Pentanoli nitris Pentyl nitrite Aspiral Vaporole 3-methylbutyl nitrite C5H11NO2 amyl nitrite snappers poppers |
Amyl Nitrite is an antihypertensive medicine. Amyl nitrite is employed medically to treat heart diseases such as angina and to treat cyanide poisoning. Like other alkyl nitrites, amyl nitrite is bioactive in mammals, being a vasodilator which is the basis of its use as a prescription medicine. As an inhalant, it also has psychoactive effect which has led to illegal drug use. Pharmacology: Amyl nitrite, in common with other alkyl nitrites, is a potent vasodilator. It expands blood vessels, resulting in lowering of the blood pressure. Alkyl nitrite functions as a source of nitric oxide, which signals for relaxation of the involuntary muscles. Physical effects include decrease in blood pressure, headache, flushing of the face, increased heart rate, dizziness, and relaxation of involuntary muscles, especially the blood vessel walls and the anal sphincter. There are no withdrawal symptoms. Mechanism of action: Amyl nitrite's antianginal action is thought to be the result of a reduction in systemic and pulmonary arterial pressure (afterload) and decreased cardiac output because of peripheral vasodilation, rather than coronary artery dilation. As an antidote (to cyanide poisoning), amyl nitrite promotes formation of methemoglobin, which combines with cyanide to form nontoxic cyanmethemoglobin. Drug type: Approved. Small Molecule. Drug category: Vasodilator Agents | Drug Drug of abuse role Inhalant |
| Anabolic steroid | Anabolic steroid | CHEBI_50786 | anabolic steroids steroids anabolic-androgenic steroid |
Drug of abuse role Anabolic agent Drug |
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| Barbiturate | Barbiturate | CHEBI_22693 | A class of drugs that act as central nervous system depressants, and, by virtue of this, they produce a wide spectrum of effects, from mild sedation to total anesthesia. They are also effective as anxiolytics, hypnotics and as anticonvulsants. They have addiction potential, both physical and psychological. (Wikipedia) | Drug of abuse role Central nervous system depressant Anesthetic drug Anticonvulsant drug Drug |
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| Boldenone | Boldenone | CHEBI_34584 | (17beta)-17-hydroxyandrosta-1 4-dien-3-one C19H26O2 1 4-androstadiene-3-one-17β-ol Equipoise Ganabol Equigan Ultragan Boldenone undecyclenate Boldenone Undeclynate |
An anabolic androgenic steroid that has formula C19H26O2. | Drug of abuse role |
| Butane | Butane | CHEBI_37808 | C4H10 | An alkane that has formula C4H10. | Drug of abuse role Inhalant |
| Chlordiazepoxide | Chlordiazepoxide | CHEBI_3611 | A-Poxide Abboxide Apo-Chlordiazepoxide Chloradiazepoxide Chlordiazachel Chlordiazepoxid Chlordiazepoxide Base Chlordiazepoxide Hcl Chlordiazepoxidum Chloridazepoxide Chloridiazepide Chloridiazepoxide Chlorodiazepoxide Chlozepid Clopoxide Clordiazepossido Contol Decacil Elenium Helogaphen Ifibrium Kalmocaps Librax Librelease Librinin Libritabs Librium Limbitrol Limbitrol Ds Lygen Menrium Mesural Methaminodiazepoxide Mildmen Multum Napoton Napton Novo-Poxide Psicosan Radepur Risolid Silibrin Tropium Viopsicol |
An anxiolytic benzodiazepine derivative with anticonvulsant, sedative, and amnesic properties. It has also been used in the symptomatic treatment of alcohol withdrawal. (PubChem) Pharmacology: Chlordiazepoxide has antianxiety, sedative, appetite-stimulating and weak analgesic actions. The precise mechanism of action is not known. The drug blocks EEG arousal from stimulation of the brain stem reticular formation. The drug has been studied extensively in many species of animals and these studies are suggestive of action on the limbic system of the brain, which recent evidence indicates is involved in emotional responses. Hostile monkeys were made tame by oral drug doses which did not cause sedation. Chlordiazepoxide revealed a "taming" action with the elimination of fear and aggression. The taming effect of chlordiazepoxide was further demonstrated in rats made vicious by lesions in the septal area of the brain. The drug dosage which effectively blocked the vicious reaction was well below the dose which caused sedation in these animals. Mechanism of action: Chlordiazepoxide binds to stereospecific benzodiazepine (BZD) binding sites on GABA (A) receptor complexes at several sites within the central nervous system, including the limbic system and reticular formation. BZDs enhance GABA-mediated chloride influx through GABA receptor channels, causing membrane hyperpolarization. The net neuro-inhibitory effects result in the observed sedative, hypnotic, anxiolytic, and muscle relaxant properties. Drug type: Approved. Illicit. Small Molecule. Drug category: Adjuvants, Anesthesia. Anti-anxiety Agents. Benzodiazepines. GABA Modulators. Hypnotics and Sedatives | Drug Drug of abuse role |
| Cocaine | Cocaine | CHEBI_27958 | Benzoylethylecgonine Benzoylmethylecgonine Beta-Cocain Cocain Cocaina Cocaine-M D-pseudococaine Delcaine Depsococaine Dextrocaine Eritroxilina Erytroxylin Isocaine Isococain Isococaine L-Cocain L-Cocaine Methyl Benzoylecgonine Neurocaine Cocaine hydrochloride Cocaine HCl |
An alkaloid ester extracted from the leaves of plants including coca. It is a local anesthetic and vasoconstrictor and is clinically used for that purpose, particularly in the eye, ear, nose, and throat. It also has powerful central nervous system effects similar to the amphetamines and is a drug of abuse. Cocaine, like amphetamines, acts by multiple mechanisms on brain catecholaminergic neurons; the mechanism of its reinforcing effects is thought to involve inhibition of dopamine uptake. (PubChem) Pharmacology: Cocaine is a local anesthetic indicated for the introduction of local (topical) anesthesia of accessible mucous membranes of the oral, laryngeal and nasal cavities. Mechanism of action: Cocaine produces anesthesia by inhibiting excitation of nerve endings or by blocking conduction in peripheral nerves. This is achieved by reversibly binding to and inactivating sodium channels. Sodium influx through these channels is necessary for the depolarization of nerve cell membranes and subsequent propagation of impulses along the course of the nerve. Cocaine is the only local anesthetic with vasoconstrictive properties. This is a result of its blockade of norepinephrine reuptake in the autonomic nervous system. Cocaine binds differentially to the dopamine, serotonin, and norepinephrine transport proteins and directly prevents the re-uptake of dopamine, serotonin, and norepinephrine into pre-synaptic neurons. Cocaine also produces a number of indirect actions, which alter other neuromodulatory systems (i.e., opioidergic, glutamatergic, and GABAergic systems). Drug type: Approved. Illicit. Small Molecule. Drug category: Anesthetics. Anesthetics, Local. Dopamine Uptake Inhibitors. Local Anesthetics. Vasoconstrictor Agents | Drug Drug of abuse role |
| Codeine | Codeine | CHEBI_16714 | Codeine anhydrous L-Codeine Methylmorphine Morphine monomethyl ether Norcodeine N-Methyl Norcodine Codicept Coducept |
An opioid analgesic related to morphine but with less potent analgesic properties and mild sedative effects. It also acts centrally to suppress cough. (PubChem) Pharmacology: Codeine, an opiate agonist in the CNS, is similar to other phenanthrene derivatives such as morphine. Codeine, in combination with guaifenesin or iodinated glycerol, is used as a cough suppressant and, as a single agent or in combination with acetaminophen or other products, is used for pain control and as an antidiarrheal agent. Mechanism of action: Opiate receptors are coupled with G-protein receptors and function as both positive and negative regulators of synaptic transmission via G-proteins that activate effector proteins. Binding of the opiate stimulates the exchange of GTP for GDP on the G-protein complex. As the effector system is adenylate cyclase and cAMP located at the inner surface of the plasma membrane, opioids decrease intracellular cAMP by inhibiting adenylate cyclase. Subsequently, the release of nociceptive neurotransmitters such as substance P, GABA, dopamine, acetylcholine and noradrenaline is inhibited. Opioids also inhibit the release of vasopressin, somatostatin, insulin and glucagon. Codeine's analgesic activity is, most likely, due to its conversion to morphine. Opioids close N-type voltage-operated calcium channels (OP2-receptor agonist) and open calcium-dependent inwardly rectifying potassium channels (OP3 and OP1 receptor agonist). This results in hyperpolarization and reduced neuronal excitability. Drug type: Approved. Illicit. Small Molecule. Drug category: Analgesics. Analgesics, Opioid. Antitussive Agents. Antitussives. Narcotics. Opiate Agonists | Drug Drug of abuse role |
| Cyclohexyl nitrite | Cyclohexyl nitrite | nlx_chem_100302 | An alkyl nitrite made from cyclohexanol. It acts as an antianginal. (Wikipedia) | Drug of abuse role Inhalant Drug |
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| Dextromethorphan | Dextromethorphan | CHEBI_4470 | D-Methorphan D-Methorphan Hydrobromide Delta-Methorphan Demorphan Demorphan Hydrobromide Demorphine Destrometerfano (Dcit) Dextromethorfan (Czech) Dextromethorphan Bromhydrate Dextromethorphan Bromide Dextrometorfano (INN-Spanish) Dextrometorphan Dextromorphan Dexyromethorphan L-Methorphan Levomethorphan Levomethorphan (Ban:Dcf:Inn) Levomethorphane (INN-French) Levomethorphanum (INN-Latin) Levometorfano (INN-Spanish) Antussan Balminil DM Benylin DM Calmylin Canfodion Cosylan Creo-Terpin Delsym Dormetan Dormethan Hihustan M Koffex DM Medicon Methorate Hydrobromide Methorphan Metrorat Novahistex DM Novahistine DM Pertussin Pertussin DM Robitussin Romilar Triaminic DM Trocal Tusilan Tussade Vicks 44 |
The d-isomer of the codeine analog of levorphanol. Dextromethorphan shows high affinity binding to several regions of the brain, including the medullary cough center. This compound is an NMDA receptor antagonist (receptors, N-methyl-D-aspartate) and acts as a non-competitive channel blocker. It is one of the widely used antitussives, and is also used to study the involvement of glutamate receptors in neurotoxicity. (PubChem) Pharmacology: Dextromethorphan suppresses the cough reflex by a direct action on the cough center in the medulla of the brain. Dextromethorphan shows high affinity binding to several regions of the brain, including the medullary cough center. This compound is an NMDA receptor antagonist and acts as a non-competitive channel blocker. It is one of the widely used antitussives, and is also used to study the involvement of glutamate receptors in neurotoxicity. Mechanism of action: Dextromethorphan is an opioid-like drug that binds to and acts as antagonist to the NMDA glutamatergic receptor, it is an agonist to the opioid sigma 1 and sigma 2 receptors, it is also an alpha3/beta4 nicotinic receptor antagonist and targets the serotonin reuptake pump. Dextromethorphan is rapidly absorbed from the gastrointestinal tract, where it enters the bloodstream and crosses the blood-brain barrier. The first-pass through the hepatic portal vein results in some of the drug being metabolized into an active metabolite of dextromethorphan, dextrorphan, the 3-hydroxy derivative of dextromethorphan. Drug type: Approved. Small Molecule. Drug category: Analgesics, Opioid. Antitussive Agents. Excitatory Amino Acid Antagonists | Drug Drug of abuse role Antagonist role |
| Diazepam | Diazepam | CHEBI_49575 | Methyldiazepinone Alboral Aliseum Alupram Amiprol Ansiolin Ansiolisina Apaurin Apo-Diazepam Apozepam Armonil Assival Atensine Atilen Bensedin Bialzepam Calmocitene Calmpose Cercine Ceregulart Diacepan Dialag Dialar Diapam Diastat Diazemuls Diazemulus Diazepam Intensol Diazepan Diazetard Dienpax Dipam Dipezona Dizac Domalium Duksen Duxen Evacalm Faustan Freudal Frustan Gewacalm Gihitan Kabivitrum Kiatrium Lembrol Levium Mandrozep Morosan Neurolytril Novazam Novo-Dipam Paceum Pacitran Paranten Paxate Paxel Plidan Quetinil Quiatril Quievita Relaminal Relanium Renborin Ruhsitus Saromet Sedapam Sedipam Seduksen Seduxen Serenack Serenamin Serenzin Servizepam Setonil Sibazon Sibazone Sonacon Stesolin Tensopam Tranimul Tranqdyn Tranquase Tranquirit Tranquo-Puren Tranquo-Tablinen Umbrium Unisedil Usempax Ap Valaxona Valeo Valiquid Valitran Valium Valrelease Vatran Zetran Zipan |
A benzodiazepine with anticonvulsant, anxiolytic, sedative, muscle relaxant, and amnesic properties and a long duration of action. Its actions are mediated by enhancement of gamma-aminobutyric acid activity. It is used in the treatment of severe anxiety disorders, as a hypnotic in the short-term management of insomnia, as a sedative and premedicant, as an anticonvulsant, and in the management of alcohol withdrawal syndrome. (From Martindale, The Extra Pharmacopoeia, 30th ed, p589) Pharmacology: Diazepam, a benzodiazepine, generates the same active metabolite as chlordiazepoxide and clorazepate. In animals, diazepam appears to act on parts of the limbic system, the thalamus and hypothalamus, and induces calming effects. Diazepam, unlike chlorpromazine and reserpine, has no demonstrable peripheral autonomic blocking action, nor does it produce extrapyramidal side effects; however, animals treated with diazepam do have a transient ataxia at higher doses. Diazepam was found to have transient cardiovascular depressor effects in dogs. Long-term experiments in rats revealed no disturbances of endocrine function. Injections into animals have produced localized irritation of tissue surrounding injection sites and some thickening of veins after intravenous use. Mechanism of action: Benzodiazepines bind nonspecifically to benzodiazepine receptors which mediate sleep, affects muscle relaxation, anticonvulsant activity, motor coordination, and memory. As benzodiazepine receptors are thought to be coupled to gamma-aminobutyric acid-A (GABAA) receptors, this enhances the effects of GABA by increasing GABA affinity for the GABA receptor. Binding of GABA to the site opens the chloride channel, resulting in a hyperpolarized cell membrane that prevents further excitation of the cell. Drug type: Approved. Illicit. Small Molecule. Drug category: Adjuvants, Anesthesia. Anesthetics, Intravenous. Anti-anxiety Agents. Anticonvulsants. Antiemetics. GABA Modulators. Hypnotics and Sedatives. Muscle Relaxants, Central | Drug Drug of abuse role |
| Fentanyl | Fentanyl | DB00813 | Fentanila (INN-Spanish) Fentanyl citrate Fentanylum (INN-Latin) fentanyl Actiq Duragesic Duragesic-100 Durogesic Fentanest Fentanil Nasalfent Pentanyl Phentanyl Rapinyl Sentonil Sublimaze |
A potent narcotic analgesic, abuse of which leads to habituation or addiction. It is primarily a mu-opioid agonist. Fentanyl is also used as an adjunct to general anesthetics, and as an anesthetic for induction and maintenance. (From Martindale, The Extra Pharmacopoeia, 30th ed, p1078) Pharmacology: Fentanyl is an opioid analgesic. Fentanyl interacts predominately with the opioid mu-receptor. These mu-binding sites are discretely distributed in the human brain, spinal cord, and other tissues. In clinical settings, Fentanyl exerts its principal pharmacologic effects on the central nervous system. Its primary actions of therapeutic value are analgesia and sedation. Fentanyl may increase the patient's tolerance for pain and decrease the perception of suffering, although the presence of the pain itself may still be recognized. In addition to analgesia, alterations in mood, euphoria and dysphoria, and drowsiness commonly occur. Fentanyl depresses the respiratory centers, depresses the cough reflex, and constricts the pupils. Mechanism of action: Opiate receptors are coupled with G-protein receptors and function as both positive and negative regulators of synaptic transmission via G-proteins that activate effector proteins. Binding of the opiate stimulates the exchange of GTP for GDP on the G-protein complex. As the effector system is adenylate cyclase and cAMP located at the inner surface of the plasma membrane, opioids decrease intracellular cAMP by inhibiting adenylate cyclase. Subsequently, the release of nociceptive neurotransmitters such as substance P, GABA, dopamine, acetylcholine and noradrenaline is inhibited. Opioids also inhibit the release of vasopressin, somatostatin, insulin and glucagon. Fentanyl's analgesic activity is, most likely, due to its conversion to morphine. Opioids close N-type voltage-operated calcium channels (OP2-receptor agonist) and open calcium-dependent inwardly rectifying potassium channels (OP3 and OP1 receptor agonist). This results in hyperpolarization and reduced neuronal excitability. Drug type: Approved. Illicit. Investigational. Small Molecule. Drug category: Adjuvants. Adjuvants, Anesthesia. Analgesics. Analgesics, Opioid. Anesthetics. Anesthetics, Intravenous. Narcotics. Opiate Agonists | Drug Drug of abuse role |
| Flunitrazepam | Flunitrazepam | DB01544 | Flunitrazepamum (inn-latin) Narcozep Primun Rohypnol Roipnol |
A benzodiazepine with pharmacologic actions similar to those of diazepam that can cause anterograde amnesia. Some reports indicate that it is used as a date rape drug and suggest that it may precipitate violent behavior. The United States Government has banned the importation of this drug. (PubChem) Pharmacology: Flunitrazepam is a powerful hypnotic drug that is a benzodiazepine derivative. It has powerful hypnotic, sedative, anxiolytic, and skeletal muscle relaxant properties. The drug is sometimes used as a date rape drug. In the United States, the drug has not been approved by the Food and Drug Administration for medical use, and is considered to be an illegal drug. It has however been approved in the United Kingdom and other countries. Mechanism of action: Benzodiazepines bind nonspecifically to benzodiazepine receptors BNZ1, which mediates sleep, and BNZ2, which affects affects muscle relaxation, anticonvulsant activity, motor coordination, and memory. As benzodiazepine receptors are thought to be coupled to gamma-aminobutyric acid-A (GABAA) receptors, this enhances the effects of GABA by increasing GABA affinity for the GABA receptor. Binding of the inhibitory neurotransmitter GABA to the site opens the chloride channel, resulting in a hyperpolarized cell membrane that prevents further excitation of the cell. Drug type: Approved. Illicit. Small Molecule. Drug category: Anti-anxiety Agents. Benzodiazepines. GABA Modulators. Hypnotics and Sedatives | Drug Drug of abuse role |
| GHB | GHB | CHEBI_16724 | Xyrem gamma-hydroxybutyrate Gamma-OH Gamma hydroxy butyrate gamma-Hydroxybutyric acid Sodium Oxybate 4-hydroxybutanoic acid 4-hydroxybutyrate 4-hydroxybutanoate |
A hydroxy monocarboxylic acid anion that has formula C4H7O3; a central nervous system (CNS) depressant that was approved by the Food and Drug Administration (FDA) in 2002 for use in the treatment of narcolepsy (a sleep disorder). GHB is also a metabolite of the inhibitory neurotransmitter gamma-aminobutyric acid (GABA); thus, it is found naturally in the brain, but at concentrations much lower than doses that are abused. | Drug of abuse role Central nervous system depressant Drug |
| Heroin | Heroin | CHEBI_27808 | diacetyl-morphine Diacetylmorphine diacetylmorphine-HCl Diacetylmorphine Hydrochloride 17-methyl-7 8-didehydro-4 5alpha-epoxymorphinan-3 6alpha-diyl diacetate |
A narcotic analgesic that may be habit-forming. It is a controlled substance (opium derivative) listed in the U.S. Code of Federal Regulations, Title 21 Parts 329.1, 1308.11 (1987). Sale is forbidden in the United States by Federal statute. (Merck Index, 11th ed) | Drug of abuse role |
| Isobutyl nitrite | Isobutyl nitrite | CHEBI_46643 | 2-methylpropyl nitrite C4H9NO2 butyl nitrite N-butyl nitrite 1-butyl nitrite |
A nitrite ester that has formula C4H9NO2. | Drug of abuse role Inhalant Drug |
| Ketamine | Ketamine | DB01221 | (-)-Ketamine (S)-(-)-Ketamine (S)-Ketamine CI 581 base Ketamine Base Ketamine HCL l-Ketamine Esketamine Ketaject Ketalar Ketanest Ketolar Ketalar SV |
A cyclohexanone derivative used for induction of anesthesia. Its mechanism of action is not well understood, but ketamine can block NMDA receptors (receptors, N-methyl-D-aspartate) and may interact with sigma receptors. (PubChem) Pharmacology: Ketamine is a rapid-acting general anesthetic producing an anesthetic state characterized by profound analgesia, normal pharyngeal-laryngeal reflexes, normal or slightly enhanced skeletal muscle tone, cardiovascular and respiratory stimulation, and occasionally a transient and minimal respiratory depression. Ketamine is indicated as the sole anesthetic agent for diagnostic and surgical procedures that do not require skeletal muscle relaxation. The anesthetic state produced by Ketamine has been termed dissociative anesthesia in that it appears to selectively interrupt association pathways of the brain before producing somesthetic sensory blockade. It may selectively depress the thalamoneocortical system before significantly obtunding the more ancient cerebral centers and pathways (reticularactivating and limbic systems). Mechanism of action: Ketamine has several clinically useful properties, including analgesia and less cardiorespiratory depressant effects than other anaesthetic agents, it also causes some stimulation of the cardiocascular system. Ketamine has been reported to produce general as well as local anaesthesia. It interacts with N-methyl-D-aspartate (NMDA) receptors, opioid receptors, monoaminergic receptors, muscarinic receptors and voltage sensitive Ca ion channels. Unlike other general anaesthetic agents, ketamine does not interact with GABA receptors. Drug type: Approved. Small Molecule. Drug category: Analgesics. Anesthetics, Dissociative. Excitatory Amino Acid Antagonists. General Anesthetics | Drug Drug of abuse role |
| LSD | LSD | CHEBI_6605 | lysergic acid diethylamide acid LSD-25 |
Drug of abuse role Hallucinogen Drug |
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| Lormetazepam | Lormetazepam | CHEBI_52993 | 7-chloro-5-(2-chlorophenyl)-3-hydroxy-1-methyl-1 3-dihydro-2H-1 4-benzodiazepin-2-one; Lorazepam; Ativan; Loramet |
A 1,4-benzodiazepinone compound having a methyl substituent at the 1-position, a hydroxy substituent at the 3-position, a 2-chlorpophenyl group at the 5-position and a chloro substituent at the 7-position. | Drug of abuse role Central nervous system depressant Drug |
| Marijuana | Marijuana | nlx_chem_100306 | cannabis THC |
Any part of, or extract from, the female hemp plant Cannabis sativa. Marijuana contains cannabinoids, substances with hallucinogenic, psychoactive, and addictive properties. This agent has potential use for treating cancer pain and cachexia (NCI Thesaurus) | Drug of abuse role Drug |
| Mescaline | Mescaline | CHEBI_28346 | 2-(3 4 5-trimethoxyphenyl)ethanamine Meskalin mescalina mezcalina C11H17NO3 |
A phenethylamine alkaloid that has formula C11H17NO3. | Drug of abuse role Hallucinogen Drug |
| Methamphetamine hydrochloride | Methamphetamine hydrochloride | CHEBI_35340 | Desoxyn | Drug of abuse role Central nervous system stimulant Drug |
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| Methaqualone | Methaqualone | nlx_chem_100307 | C16H14N2O | A nonbarbiturate sedative-hypnotic, unrelated chemically to other sedatives, it is tasteless, odorless and potentially habit-forming. | Drug of abuse role Central nervous system depressant Drug |
| Methaqualone hydrochloride | Methaqualone hydrochloride | nlx_chem_100308 | Parest Optimil Somnafac |
Drug of abuse role Drug |
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| Methylphenidate | Methylphenidate | CHEBI_6887 | Methyl phenidyl acetate Methylphenidate HCl Methylphenidate hydrochloride Methylphenidatum (INN-Latin) Methylphenidylacetate hydrochloride Metilfenidat hydrochloride Metilfenidato (INN-Spanish) Metilfenidato (Italian) Phenidylate d-methylphenidate HCl methylphenidate 4311/B Ciba Calocain Centedein Centedrin Centedrine Centredin Concerta Daytrana Focalin Focalin XR Meridil Metadate Metadate CD Metadate ER Methylin Methylin ER Methylofenidan Methylphen Methylphenidan Methypatch PMS-Methylphenidate Plimasine Riphenidate Ritalin Ritalin LA Ritalin SR Ritalin hydrochloride Ritalin-SR Ritaline Ritcher Works |
A central nervous system stimulant used most commonly in the treatment of attention-deficit disorders in children and for narcolepsy. Its mechanisms appear to be similar to those of dextroamphetamine. (PubChem) Pharmacology: Methylphenidate is a central nervous system stimulant used most commonly in the treatment of attention-deficit disorders in children and for narcolepsy. Its mechanisms appear to be similar to those of dextroamphetamine. Mechanism of action: Methylphenidate blocks dopamine uptake in central adrenergic neurons by blocking dopamine transport or carrier proteins. Methylphenidate acts at the brain stem arousal system and the cerebral cortex and causes increased sympathomimetic activity in the central nervous system. Alteration of serotonergic pathways via changes in dopamine transport may result. Drug type: Approved. Investigational. Small Molecule. Drug category: Adrenergic Agents. Adrenergic Uptake Inhibitors. Central Nervous System Stimulants. Dopamine Uptake Inhibitors. Sympathomimetics | Drug Drug of abuse role |
| Morphine | Morphine | CHEBI_17303 | (-)-Heroin hydrochloride (-)-Morphine D-(-)-Morphine Diacetylmorphine hydrochloride Diamorphine hydrochloride Heroin hydrochloride Heroine hydrochloride Morphin Morphina Morphine Sulfate Morphinum O'-Diacetylmorphine hydrochloride Apokyn Astramorph PF Avinza Depodur Dulcontin Duramorph PF Duromorph Epimorph Kadian M-Eslon MSIR Meconium Morfina Morphia Morphine Extra-Forte Morphine Forte Morphine H Morphinism Morphitec Morphium Moscontin Ms Contin Nepenthe Oramorph SR Ospalivina RMS Uniserts Rescudose Roxanol Roxanol 100 Roxanol UD Statex l-Morphine Morphine hydrochloride |
The principal alkaloid in opium and the prototype opiate analgesic and narcotic. Morphine has widespread effects in the central nervous system and on smooth muscle. (PubChem) Pharmacology: Morphine is a narcotic pain management agent indicated for the relief of pain in patients who require opioid analgesics for more than a few days. Morphine interacts predominantly with the opioid mu-receptor. These mu-binding sites are discretely distributed in the human brain, with high densities in the posterior amygdala, hypothalamus, thalamus, nucleus caudatus, putamen, and certain cortical areas. They are also found on the terminal axons of primary afferents within laminae I and II (substantia gelatinosa) of the spinal cord and in the spinal nucleus of the trigeminal nerve. In clinical settings, morphine exerts its principal pharmacological effect on the central nervous system and gastrointestinal tract. Its primary actions of therapeutic value are analgesia and sedation. Morphine appears to increase the patient's tolerance for pain and to decrease discomfort, although the presence of the pain itself may still be recognized. In addition to analgesia, alterations in mood, euphoria and dysphoria, and drowsiness commonly occur. Opioids also produce respiratory depression by direct action on brain stem respiratory centers. Mechanism of action: The precise mechanism of the analgesic action of morphine is unknown. However, specific CNS opiate receptors have been identified and likely play a role in the expression of analgesic effects. The mechanism of respiratory depression involves a reduction in the responsiveness of the brain stem respiratory centers to increases in carbon dioxide tension and to electrical stimulation. Drug type: Approved. Investigational. Small Molecule. Drug category: Analgesics. Analgesics, Opioid. Narcotics. Opiate Agonists | Drug Drug of abuse role |
| Nandrolone | Nandrolone | CHEBI_7466 | 19NTPP NPP NTPP Nadrolone Phenylpropionate Nandrolin Nandrolon Phenylpropionate Nandrolone Phenylpionate Nandrolone Phenylpropionate Norandrolone Phenyl Propionate Norandrostenolone Phenylpropionate Nortestosterone Phenylpropionate Testosterone Phenylpropionate Activin Deca-Durabolin Durabol Durabolin FTS Fenobolin Nandrobolic Nerobil Nerobiolil Nerobolil Phenobolin Strabolene Superanabolon |
C18 steroid with androgenic and anabolic properties. It is generally prepared from alkyl ethers of estradiol to resemble testosterone but less one carbon at the 19 position. Pharmacology: Nandrolone is an anabolic steroid occurring naturally in the human body, albeit in small quantities. Nandrolone increases production and urinary excretion of erythropoietin. It may also have a direct action on bone marrow. Nandrolone binds to the androgen receptor to a greater degree than testosterone, but due to its inability to act on the muscle in ways unmediated by the receptor, has less overall effect on muscle growth. Mechanism of action: Nandrolone is an androgen receptor agonist. Drug type: Approved. Illicit. Small Molecule. Drug category: Anabolic Agents. Androgens | Drug Drug of abuse role |
| Nicotine | Nicotine | CHEBI_18723 | L-Nicotine Nicotine Alkaloid Fumetobac Habitrol Nicocide Nicoderm Nicoderm Cq Nicorette Nicorette Plus Nicotin Nicotina Nicotine Polacrilex Nicotrol Nicotrol Inhaler Nicotrol Ns Nikotin Nikotyna Nicotine bitartrate |
Nicotine is highly toxic alkaloid. It is the prototypical agonist at nicotinic cholinergic receptors where it dramatically stimulates neurons and ultimately blocks synaptic transmission. Nicotine is also important medically because of its presence in tobacco smoke. (PubChem) Pharmacology: Nicotine, the primary alkaloid in tobacco products binds stereo-selectively to nicotinic-cholinergic receptors on autonomic ganglia, the adrenal medulla, neuromuscular junctions and in the brain. Nicotine exerts two effects, a stimulant effect exerted at the locus ceruleus and a reward effect in the limbic system. Itranvenous administration of nicotine causes release of acetylcholine, norepinephrine, dopamine, serotonine, vasopressin, beta-endorphin and ACTH. Nicotine is a highly addictive substance. Nicotine also induces peripheral vasoconstriction, tachycardia and elevated blood pressure. Nicotine inhalers and patches are used to treat smoking withdrawl syndrome. Nicotine is classified as a stimulant of autonomic ganglia. Mechanism of action: Nicotine binds to the nicotinic acetylcholine receptor. Stimulation of nicotinic receptors leads to a variety of cholinergic and adrenergic effects; tachycardia or bradycardia mediated by either stimulation or interference with sympathetic or parasympathetic pathways, stimulation of receptors in the carotic and aortic bodies, release of epinephrine from the adrenal medulla, and stimulation of the chemoreceptor-trigger zone. Drug type: Approved. Small Molecule. Drug category: Anti-craving Agents. Autonomic drugs. Central Nervous System Agents. Ganglionic Stimulants. Nicotinic Agonists | Drug Drug of abuse role |
| Nitrous oxide | Nitrous oxide | CHEBI_17045 | dinitrogen oxide oxidodinitrogen(N--N) |
A nitrogen oxide that has formula N2O. | Drug of abuse role Inhalant Drug |
| Opium | Opium | nlx_chem_100309 | Drug of abuse role Drug |
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| Oxandrolone | Oxandrolone | CHEBI_7820 | Ossandrolone (DCIT) Oxandrolona (INN-Spanish) Oxandrolonum (INN-Latin) oxandrolone Anavar Lonavar Oxandrin Protivar Provitar Vasorome |
A synthetic hormone with anabolic and androgenic properties. (PubChem) Pharmacology: Oxandrolone is an anabolic steroids indicated as adjunctive therapy to promote weight gain after weight loss following extensive surgery, chronic infections, or severe trauma, and in some patients who without definite pathophysiologic reasons fail to gain or to maintain normal weight, to offset the protein catabolism associated with prolonged administration of corticosteroids, and for the relief of the bone pain frequently accompanying osteoporosis. Anabolic steroids are synthetic derivatives of testosterone. Mechanism of action: Oxandrolones interact with androgen receptors in target tissues. Drug type: Approved. Investigational. Small Molecule. Drug category: Anabolic Agents. Androgens | Drug Drug of abuse role |
| Oxycodone hydrochloride | Oxycodone hydrochloride | CHEBI_7859 | oxycodone HCL Oxycontin 14-hydroxy-3-methoxy-17-methyl-4 5alpha-epoxymorphinan-6-one hydrochloride |
A hydrochloride that has formula C18H22ClNO4. | Drug of abuse role Drug |
| Oxymetholone | Oxymetholone | nlx_chem_100310 | Anadrol C21H32O3 |
A synthetic anabolic steroid developed by Zoltan 'Anadrol Z' F. in 1960. Its primary clinical applications include treatment of osteoporosis and anaemia, as well as stimulating muscle growth in undernourished or underdeveloped patients. (Wikipedia) | Drug of abuse role Drug |
| Pentobarbital | Pentobarbital | CHEBI_7983 | Pentabarbital Pentabarbitone Pentobarbital Sodium Pentobarbitone Pentobarbiturate Pentobarbituric acid Sodium Pentobarbital Dorsital Ethaminal Mebubarbital Mebumal Nebralin Nembutal Nembutal Sodium Neodorm Rivadorm |
A short-acting barbiturate that is effective as a sedative and hypnotic (but not as an anti-anxiety) agent and is usually given orally. It is prescribed more frequently for sleep induction than for sedation but, like similar agents, may lose its effectiveness by the second week of continued administration. (From AMA Drug Evaluations Annual, 1994, p236) Pharmacology: Pentobarbital, a barbiturate, is used for the treatment of short term insomnia. It belongs to a group of medicines called central nervous system (CNS) depressants that induce drowsiness and relieve tension or nervousness. Little analgesia is conferred by barbiturates; their use in the presence of pain may result in excitation. Mechanism of action: Pentobarbital binds at a distinct binding site associated with a Cl- ionopore at the GABAA receptor, increasing the duration of time for which the Cl- ionopore is open. The post-synaptic inhibitory effect of GABA in the thalamus is, therefore, prolonged. All of these effects are associated with marked decreases in GABA-sensitive neuronal calcium conductance (gCa). The net result of barbiturate action is acute potentiation of inhibitory GABAergic tone. Barbiturates also act through potent (if less well characterized) and direct inhibition of excitatory AMPA-type glutamate receptors, resulting in a profound suppression of glutamatergic neurotransmission. Drug type: Approved. Small Molecule. Drug category: Adjuvants, Anesthesia. Barbiturates. GABA Modulators. Hypnotics and Sedatives | Drug Drug of abuse role |
| Phencyclidine | Phencyclidine | nlx_chem_100311 | phenylcyclohexylpiperidine | Drug of abuse role Dissociative drug Anesthetic drug NMDA (N-methyl d-aspartate) receptor antagonist Drug |
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| Phenobarbital | Phenobarbital | CHEBI_8069 | Fenobarbital Phenobarbitol Phenobarbituric Acid Phenylethylbarbiturate Phenylethylbarbituric Acid Phenylethylmalonylurea Adonal Aephenal Agrypnal Amylofene Aphenylbarbit Aphenyletten Barbenyl Barbinal Barbiphen Barbiphenyl Barbipil Barbita Barbivis Barbonal Barbophen Bardorm Bartol Bialminal Blu-Phen Cabronal Calmetten Calminal Cardenal Chinoin Codibarbita Coronaletta Cratecil Damoral Dezibarbitur Dormina Dormiral Dormital Doscalun Duneryl Ensobarb Ensodorm Epanal Epidorm Epilol Episedal Epsylone Eskabarb Etilfen Euneryl Fenbital Fenemal Fenosed Fenylettae Gardenal Gardepanyl Glysoletten Haplopan Haplos Helional Hennoletten Henotal Hypnaletten Hypnette Hypno-Tablinetten Hypnogen Hypnolone Hypnoltol Hysteps Lefebar Leonal Lephebar Lepinal Lepinaletten Linasen Liquital Lixophen Lubergal Lubrokal Lumen Lumesettes Lumesyn Luminal Lumofridetten Luphenil Luramin Molinal Neurobarb Nirvonal Noptil Nova-Pheno Nunol Parkotal Pharmetten Phen-Bar Phenaemal Phenemal Phenemalum Phenobal Phenobarbyl Phenoluric Phenolurio Phenomet Phenonyl Phenoturic Phenyletten Phenyral Phob Polcominal Promptonal Seda-Tablinen Sedabar Sedicat Sedizorin Sedlyn Sedofen Sedonal Sedonettes Sevenal Sinoratox Solfoton Solfoton Talpheno Solu-Barb Sombutol Somnolens Somnoletten Somnosan Somonal Spasepilin Starifen Starilettae Stental Stental Extentabs Talpheno Teolaxin Teoloxin Thenobarbital Theoloxin Triabarb Tridezibarbitur Triphenatol Versomnal Zadoletten Zadonal |
A barbituric acid derivative that acts as a nonselective central nervous system depressant. It promotes binding to inhibitory gamma-aminobutyric acid subtype receptors, and modulates chloride currents through receptor channels. It also inhibits glutamate induced depolarizations. (PubChem) Pharmacology: Phenobarbital, the longest-acting barbiturate, is used for its anticonvulsant and sedative-hypnotic properties in the management of all seizure disorders except absence (petit mal). Mechanism of action: Phenobarbital acts on GABAA receptors, increasing synaptic inhibition. This has the effect of elevating seizure threshold and reducing the spread of seizure activity from a seizure focus. Phenobarbital may also inhibit calcium channels, resulting in a decrease in excitatory transmitter release. The sedative-hypnotic effects of phenobarbital are likely the result of its effect on the polysynaptic midbrain reticular formation, which controls CNS arousal. Drug type: Approved. Small Molecule. Drug category: Anticonvulsants. Excitatory Amino Acid Antagonists. GABA Modulators. Hypnotics and Sedatives | Drug Drug of abuse role |
| Psilocybin | Psilocybin | CHEBI_8614 | The major hallucinogenic alkaloid isolated from Psilocybe mushrooms (also known as Teonanacatl or "magic mushrooms"). | Drug of abuse role Hallucinogen Drug |
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| Secobarbital | Secobarbital | CHEBI_9073 | (+/-)-Secobarbital Secobarbital Sodium Secobarbitale (DCIT) Secobarbitalum (INN-Latin) Sodium Secobarbital Sodium quinalbarbitone Barbosec Bipanal Bipinal sodium Evronal Evronal Sodium Evrronal Hypotrol Hyptran Imesonal Immenoctal Immenox Meballymal Meballymal sodium Meballymalum Novosecobarb Pramil Quinalbarbital Quinalbarbitone Quinalbarbitone sodium Quinalspan Sebar Seco 8 Secobarbitone Seconal Sedutain Seotal Somosal Synate Trisomnin |
Secobarbital (marketed by Eli Lilly and Company under the brand names Seconal and Tuinal) is a barbiturate derivative drug. It possesses anaesthetic, anticonvulsant, sedative and hypnotic properties. In the United Kingdom, it was known as Quinalbarbitone. Pharmacology: Secobarbital, a barbiturate, is used for the induction of anesthesia prior to the use of other general anesthetic agents and for induction of anesthesia for short surgical, diagnostic, or therapeutic procedures associated with minimal painful stimuli. Little analgesia is conferred by barbiturates; their use in the presence of pain may result in excitation. Mechanism of action: Secobarbital binds at a distinct binding site associated with a Cl- ionopore at the GABAA receptor, increasing the duration of time for which the Cl- ionopore is open. The post-synaptic inhibitory effect of GABA in the thalamus is, therefore, prolonged. Drug type: Approved. Small Molecule. Drug category: Adjuvants. Adjuvants, Anesthesia. Barbiturates. GABA Modulators. Hypnotics and Sedatives | Drug Drug of abuse role |
| Testosterone | Testosterone | CHEBI_17347 | Testosteron Testosterona (INN-Spanish) Testosterone Cypionate Testosterone Enanthate Testosterone Hydrate Testosteronum (INN-Latin) Testostosterone Trans-Testosterone testosterone Andriol Andro Andro 100 Andro L Androderm Androgel Android 10 Android 25 Android 5 Androlin Andronaq Andronate 100 Andronate 200 Andropatch Andropository 200 Androsorb Andrusol Andryl 200 Beta Testosterone CDB 111C Cristerona T Cristerone T Delatest Delatestryl Depo-Testosterone Depo-Testosterone Cypionate Depotest Everone 200 Geno-Cristaux Gremy Homosteron Homosterone Libigel Malerone Malestrone Malogen Aquaspension Mertestate Metandren Methyltestosterone Neo-Hombreol F Neo-Testis Neotestis Oreton Oreton F Oreton Methyl Oreton-F Orquisteron Perandren Percutacrine Androgenique Primotest Primoteston Relibra Scheinpharm Testone-Cyp Striant Sustanon Sustanone Sustason 250 Synandrol F T-Cypionate Teslen Testamone 100 Testandrone Testaqua Testiculosterone Testim Testobase Testoderm Testoderm Tts Testogel Testoject-50 Testolin Testopel Pellets Testopropon Testosteroid Testoviron Testoviron Schering Testoviron T Testred Testred Cypionate 200 Testrin-P A Testro Aq Testrone Testryl Virilon Virilon IM Virormone Virosterone |
A potent androgenic steroid and major product secreted by the leydig cells of the testis. Its production is stimulated by luteinizing hormone from the pituitary gland. In turn, testosterone exerts feedback control of the pituitary LH and FSH secretion. Depending on the tissues, testosterone can be further converted to dihydrotestosterone or estradiol. (PubChem) Pharmacology: Testosterone is a steroid hormone from the androgen group. Testosterone is primarily secreted in the testes of males and the ovaries of females although small amounts are secreted by the adrenal glands. It is the principal male sex hormone and an anabolic steroid. In both males and females, it plays key roles in health and well-being. Examples include enhanced libido, energy, immune function, and protection against osteoporosis. On average, the adult male body produces about twenty times the amount of testosterone than an adult female's body does. Mechanism of action: The effects of testosterone in humans and other vertebrates occur by way of two main mechanisms: by activation of the androgen receptor (directly or as DHT), and by conversion to estradiol and activation of certain estrogen receptors. Free testosterone (T) is transported into the cytoplasm of target tissue cells, where it can bind to the androgen receptor, or can be reduced to 5-dihydrotestosterone (DHT) by the cytoplasmic enzyme 5-reductase. DHT binds to the same androgen receptor even more strongly than T, so that its androgenic potency is about 2.5 times that of T. The T-receptor or DHT-receptor complex undergoes a structural change that allows it to move into the cell nucleus and bind directly to specific nucleotide sequences of the chromosomal DNA. The areas of binding are called hormone response elements (HREs), and influence transcriptional activity of certain genes, producing the androgen effects. Drug type: Approved. Investigational. Small Molecule. Drug category: Androgens | Drug Drug of abuse role |
| Testosterone cypionate | Testosterone cypionate | CHEBI_9463 | 3-oxoandrost-4-en-17beta-yl 3-cyclopentylpropanoate C27H40O3 Depo- Testosterone |
A sterol ester that has formula C27H40O3. | Drug of abuse role Drug |
| Tetrahydrocannabinol | Tetrahydrocannabinol | nifext_5031 | delta-9-tetrahydrocannabinol Δ9-THC Δ1-THC Delta9-THC delta9-tetrahydrocannabinol 9-tetrahydrocannabinol Delta(9)-tetrahydrocannabinol |
The main psychoactive substance found in the Cannabis plant. (Wikipedia) | Drug of abuse role Drug |
| Triazolam | Triazolam | CHEBI_9674 | DEA No 2887 Triazolamum (INN-Latin) Alti-Triazolam Apo-Triazo Clorazolam Gen-Triazolam Halcion Novidorm Novo-Triolam Novodorm Songar |
Withdrawn in the United Kingdom due to risk of psychiatric adverse drug reactions. This drug continues to be available in the U.S. Internationally, triazolam is a Schedule IV drug under the Convention on Psychotropic Substances. Pharmacology: A short-acting benzodiazepine used as a hypnotic agent in the treatment of insomnia. Some countries temporarily withdrew triazolam from the market because of concerns about adverse reactions, mostly psychological, associated with higher dose ranges. Its use at lower doses with appropriate care and labeling has been reaffirmed by the FDA and most other countries. Triazolam has a shorter half-life than chlordiazepoxide, flurazepam, and prazepam and does not generate active metabolites. Mechanism of action: Benzodiazepines bind nonspecifically to bezodiazepine receptors BNZ1, which mediates sleep, and BNZ2, which affects affects muscle relaxation, anticonvulsant activity, motor coordination, and memory. As benzodiazepine receptors are thought to be coupled to gamma-aminobutyric acid-A (GABAA) receptors, this enhances the effects of GABA by increasing GABA affinity for the GABA receptor. Binding of GABA to the site opens the chloride channel, resulting in a hyperpolarized cell membrane that prevents further excitation of the cell. Drug type: Approved. Illicit. Small Molecule. Withdrawn. Drug category: Adjuvants, Anesthesia. Anti-anxiety Agents. Benzodiazepines. GABA Modulators | Drug Drug of abuse role |
| Vicodin | Vicodin | nlx_chem_100313 | is a brand mixture of two drugs: acetaminophen + hydrocodone bitartrate | Drug of abuse role Drug |
Facts about Drug of abuseRDF feed
| CurationStatus | uncurated + |
| Definition | Any substance that is defined by the national institutes of drug abuse as being an abused drug. |
| Id | nlx_chem_1003011 + |
| Label | Drug of abuse + |
| ModifiedDate | 23 July 2012 + |
| SuperCategory | Defined class + |
| Synonym | abused drug +, illegal drug +, and illicit drug + |