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Econazole

Name: Econazole
Description: A broad spectrum antimycotic with some action against Gram positive bacteria. It is used topically in dermatomycoses also orally and parenterally. (PubChem) Pharmacology: Econazole is an antifungal medication related to fluconazole (Diflucan), ketoconazole (Nizoral), itraconazole (Sporanox), and clotrimazole (Lotrimin, Mycelex). Econazole prevents fungal organisms from producing vital substances required for growth and function. This medication is effective only for infections caused by fungal organisms. It will not work for bacterial or viral infections. Mechanism of action: Econazole interacts with 14- demethylase, a cytochrome P-450 enzyme necessary to convert lanosterol to ergosterol. As ergosterol is an essential component of the fungal cell membrane, inhibition of its synthesis results in increased cellular permeability causing leakage of cellular contents. Econazole may also inhibit endogenous respiration, interact with membrane phospholipids, inhibit the transformation of yeasts to mycelial forms, inhibit purine uptake, and impair triglyceride and/or phospholipid biosynthesis. Drug type: Approved. Small Molecule. Drug category: Antifungal Agents
Synonym(s): Econazole Nitrate, Ecostatin, Ecostatin Vaginal Ovules, Ecostatin cream, Gyno-Pevaryl, Gyno-Pevaryl 150, Ifenec, Palavale, Pevaryl, Spectazole, Spectazole cream
Related to: Cytochrome P450 51
Has role: Drug
Super-category: Molecular entity
URL: http://www.drugbank.ca/drugs/DB01127
Id: CHEBI_4754
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Facts about EconazoleRDF feed
Commenttaken from DrugBank
CurationStatusuncurated  +
CuratorAb  +
DefiningCitationhttp://www.drugbank.ca/drugs/DB01127  +
DefinitionA broad spectrum antimycotic with some act A broad spectrum antimycotic with some action against Gram positive bacteria. It is used topically in dermatomycoses also orally and parenterally. (PubChem) Pharmacology: Econazole is an antifungal medication related to fluconazole (Diflucan), ketoconazole (Nizoral), itraconazole (Sporanox), and clotrimazole (Lotrimin, Mycelex). Econazole prevents fungal organisms from producing vital substances required for growth and function. This medication is effective only for infections caused by fungal organisms. It will not work for bacterial or viral infections. Mechanism of action: Econazole interacts with 14- demethylase, a cytochrome P-450 enzyme necessary to convert lanosterol to ergosterol. As ergosterol is an essential component of the fungal cell membrane, inhibition of its synthesis results in increased cellular permeability causing leakage of cellular contents. Econazole may also inhibit endogenous respiration, interact with membrane phospholipids, inhibit the transformation of yeasts to mycelial forms, inhibit purine uptake, and impair triglyceride and/or phospholipid biosynthesis. Drug type: Approved. Small Molecule. Drug category: Antifungal Agents Molecule. Drug category: Antifungal Agents
Has roleDrug  +
IdCHEBI_4754  +
LabelEconazole  +
ModifiedDate14 April 2014  +
RelatedToCytochrome P450 51  +
SuperCategoryMolecular entity  +
SynonymEconazole Nitrate  +, Ecostatin  +, Ecostatin Vaginal Ovules  +, Ecostatin cream  +, Gyno-Pevaryl  +, Gyno-Pevaryl 150  +, Ifenec  +, Palavale  +, Pevaryl  +, Spectazole  +, and Spectazole cream  +