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Edetic Acid

Name: Edetic Acid
Description: A chelating agent (chelating agents) that sequesters a variety of polyvalent cations. It is used in pharmaceutical manufacturing and as a food additive. (PubChem) Pharmacology: Edetate calcium is a heavy metal chelating agent. The calcium in edetate calcium can be displaced by divalent or trivalent metals to form a stable water soluble complex that can be excreted in the urine. In theory, 1 g of edetate calcium can theoretically bind 620 mg of lead, but in reality only about 5 mg per gram is actually excreted into the urine in lead poisoned patients. In addition to chelating lead, edetate calcium also chelates and eliminates zinc from the body. Edetate calcium also binds cadmium, copper, iron and manganese, but to a much lesser extent than either lead or zinc. Edetate calcium is relatively ineffective for use in treating mercury, gold or arsenic poisoning. Mechanism of action: The pharmacologic effects of edetate calcium disodium are due to the formation of chelates with divalent and trivalent metals. A stable chelate will form with any metal that has the ability to displace calcium from the molecule, a feature shared by lead, zinc, cadmium, manganese, iron and mercury. The amounts of manganese and iron metabolized are not significant. Copper is not mobilized and mercury is unavailable for chelation because it is too tightly bound to body ligands or it is stored in inaccessible body compartments. The excretion of calcium by the body is not increased following intravenous administration of edetate calcium disodium, but the excretion of zinc is considerably increased. Drug type: Approved. Small Molecule. Drug category: Anticoagulants. Chelating Agents. Food Additives
Synonym(s): CaEDTA, Calcium Disodium Edetate (JAN), Calcium Disodium Versenate, Calcium disodium versenate (TN), EDT, EDTA, Edetate Calcium, Edetate calcium disodium (USP), Cheladrate, Endrate, Havidote, Titriplex, Versenate
Has role: Drug
Super-category: Molecular entity
URL: http://www.drugbank.ca/drugs/DB00974
*Id: DB00974
Link to OWL / RDF: Download this content as OWL/RDF


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Facts about Edetic AcidRDF feed
Commenttaken from DrugBank
CuratorAb  +
DefiningCitationhttp://www.drugbank.ca/drugs/DB00974  +
DefinitionA chelating agent (chelating agents) that A chelating agent (chelating agents) that sequesters a variety of polyvalent cations. It is used in pharmaceutical manufacturing and as a food additive. (PubChem) Pharmacology: Edetate calcium is a heavy metal chelating agent. The calcium in edetate calcium can be displaced by divalent or trivalent metals to form a stable water soluble complex that can be excreted in the urine. In theory, 1 g of edetate calcium can theoretically bind 620 mg of lead, but in reality only about 5 mg per gram is actually excreted into the urine in lead poisoned patients. In addition to chelating lead, edetate calcium also chelates and eliminates zinc from the body. Edetate calcium also binds cadmium, copper, iron and manganese, but to a much lesser extent than either lead or zinc. Edetate calcium is relatively ineffective for use in treating mercury, gold or arsenic poisoning. Mechanism of action: The pharmacologic effects of edetate calcium disodium are due to the formation of chelates with divalent and trivalent metals. A stable chelate will form with any metal that has the ability to displace calcium from the molecule, a feature shared by lead, zinc, cadmium, manganese, iron and mercury. The amounts of manganese and iron metabolized are not significant. Copper is not mobilized and mercury is unavailable for chelation because it is too tightly bound to body ligands or it is stored in inaccessible body compartments. The excretion of calcium by the body is not increased following intravenous administration of edetate calcium disodium, but the excretion of zinc is considerably increased. Drug type: Approved. Small Molecule. Drug category: Anticoagulants. Chelating Agents. Food Additives agulants. Chelating Agents. Food Additives
Has roleDrug  +
IdDB00974  +
LabelEdetic Acid  +
ModifiedDate14 April 2014  +
SuperCategoryMolecular entity  +
SynonymCaEDTA  +, Calcium Disodium Edetate (JAN)  +, Calcium Disodium Versenate  +, Calcium disodium versenate (TN)  +, EDT  +, EDTA  +, Edetate Calcium  +, Edetate calcium disodium (USP)  +, Cheladrate  +, Endrate  +, Havidote  +, Titriplex  +, and Versenate  +