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Epinephrine

Name: Epinephrine
Description: The active sympathomimetic hormone from the adrenal medulla in most species. It stimulates both the alpha- and beta- adrenergic systems, causes systemic vasoconstriction and gastrointestinal relaxation, stimulates the heart, and dilates bronchi and cerebral vessels. It is used in asthma and cardiac failure and to delay absorption of local anesthetics. (PubChem) Pharmacology: Epinephrine is indicated for intravenous injection in treatment of acute hypersensitivity, treatment of acute asthmatic attacks to relieve bronchospasm, and treatment and prophylaxis of cardiac arrest and attacks of transitory atrioventricular heart block with syncopal seizures (Stokes-Adams Syndrome). The actions of epinephrine resemble the effects of stimulation of adrenergic nerves. To a variable degree it acts on both alpha and beta receptor sites of sympathetic effector cells. Its most prominent actions are on the beta receptors of the heart, vascular and other smooth muscle. When given by rapid intravenous injection, it produces a rapid rise in blood pressure, mainly systolic, by (1) direct stimulation of cardiac muscle which increases the strength of ventricular contraction, (2) increasing the heart rate and (3) constriction of the arterioles in the skin, mucosa and splanchnic areas of the circulation. When given by slow intravenous injection, epinephrine usually produces only a moderate rise in systolic and a fall in diastolic pressure. Although some increase in pulse pressure occurs, there is usually no great elevation in mean blood pressure. Accordingly, the compensatory reflex mechanisms that come into play with a pronounced increase in blood pressure do not antagonize the direct cardiac actions of epinephrine as much as with catecholamines that have a predominant action on alpha receptors. Mechanism of action: Epinephrine works via the stimulation of alpha and beta-1 adrenergic receptors, and a moderate activity at beta-2 adrenergic receptors. Drug type: Approved. Small Molecule. Drug category: Adrenergic Agonists. Adrenergic alpha-Agonists. Adrenergic beta-Agonists. Bronchodilator Agents. Mydriatics. Sympathomimetics. Vasoconstrictor Agents
Synonym(s): ADR Adrenaline, Adrenalin, Adrenalin Chloride, Adrenalina, Adrenaline, Adrenalinum, D-Adrenaline, D-Epifrin, D-Epinephrine, Epinefrin (Czech), Epinefrina (INN-Spanish), Epinephran, Epinephrine Bitartrate, Epinephrinum (INN-Latin), L-Adrenalin, L-Adrenaline, L-Adrenaline Base, L-Epinephine, L-Epinephrine, L-Epirenamine, Levoadrenaline, Levoepinephrine, Racepinefrina (inn-spanish), Racepinefrine, Racepinefrinum (inn-latin), Racepinephrine, ADROP, Adnephrine, Adrenal, Adrenalin-Medihaler, Adrenamine, Adrenan, Adrenapax, Adrenasol, Adrenatrate, Adrenine, Adrenodis, Adrenohorma, Adrenor, Adrenosan, Adrenutol, Adrin, Adrine, Aktamin, Ana-Guard, Antiasthmatique, Asmatane Mist, Asthma Meter Mist, Asthma-Nefrin, Asthmahaler Mist, Asthmanefrin, Astmahalin, Astminhal, Balmadren, Bernarenin, Biorenine, Bosmin, Brevirenin, Bronkaid, Bronkaid Mist, Bronkaid Suspension Mist, Chelafrin, Citanest Forte, Corisol, Drenamist, Duranest, Dylephrin, Epi EZ Pen Jr, Epifrin, Epiglaufrin, Epipen, Epipen Auto-Injector, Epipen EZ Pen, Epipen Jr, Epipen Jr, Auto-Injector, Epirenamine, Epirenan, Epirenin, Epitrate, Eppy, Esphygmogenina, Exadrin, Glaucon, Glaucosan, Glauposine, Glycirenan, Haemostasin, Haemostatin, Hektalin, Hemisine, Hemostasin, Hemostatin, Hypernephrin, Hyporenin, IOP, Intranefrin, Iontocaine, Isoptoepinal, Kidoline, Levonor, Levorenen, Levorenin, Levorenine, Lidocaton, Lyophrin, Medihaler-Epi, Metanephrin, Micronefrin, Mucidrina, Myosthenine, Mytrate, Nephridine, Nephron, Nieraline, Nor-Epirenan, Norartrinal, Paranephrin, Primatene Mist, Renagladin, Renaglandin, Renaglandulin, Renaleptine, Renalina, Renoform, Renostypricin, Renostypticin, Renostyptin, Scurenaline, Septocaine, Simplene, Sindrenina, Soladren, Sphygmogenin, Stryptirenal, Styptirenal, Supracapsulin, Supradin, Supranefran, Supranephrane, Supranephrine, Supranol, Suprarenaline, Suprarenin, Suprel, Surenine, Surrenine, Sus-Phrine, Susphrine, Sympathin E, Sympathin I, Takamina, Takamine, Tokamina, Tolansin, Tolax, Tolcil, Tolhart, Tonogen, Twinject, Vaponefrin, Vasoconstrictine, Vasodrine, Vasoton, Vasotonin
Abbreviation: EPI
Is part of: Catecholamine system, Adrenergic system, Noradrenergic system
Has role: Drug, Hormone, Neurotransmitter
Super-category: Molecular entity
URL: http://www.drugbank.ca/drugs/DB00668
*Id: DB00668
Related to: Beta-1 adrenergic receptor, Alpha-1A adrenergic receptor, Beta-2 adrenergic receptor, Phenylalanine-4-hydroxylase
Link to OWL / RDF: Download this content as OWL/RDF

Categories related to Epinephrine

Adrenoceptor receptor, Alpha1A receptor, Alpha1B receptor, Alpha1D receptor, Alpha2A receptor, Alpha2B receptor, Alpha2C receptor, Alpha2D receptor, Beta1 receptor, Beta2 receptor, Beta3 receptor, Phenylethanolamine N-Methyltransferase, S-Adenosylmethionine




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Facts about EpinephrineRDF feed
AbbrevEPI  +
Commenttaken from DrugBank
CurationStatusuncurated  +
CuratorAb  +
DefiningCitationhttp://www.drugbank.ca/drugs/DB00668  +
DefinitionThe active sympathomimetic hormone from th The active sympathomimetic hormone from the adrenal medulla in most species. It stimulates both the alpha- and beta- adrenergic systems, causes systemic vasoconstriction and gastrointestinal relaxation, stimulates the heart, and dilates bronchi and cerebral vessels. It is used in asthma and cardiac failure and to delay absorption of local anesthetics. (PubChem) Pharmacology: Epinephrine is indicated for intravenous injection in treatment of acute hypersensitivity, treatment of acute asthmatic attacks to relieve bronchospasm, and treatment and prophylaxis of cardiac arrest and attacks of transitory atrioventricular heart block with syncopal seizures (Stokes-Adams Syndrome). The actions of epinephrine resemble the effects of stimulation of adrenergic nerves. To a variable degree it acts on both alpha and beta receptor sites of sympathetic effector cells. Its most prominent actions are on the beta receptors of the heart, vascular and other smooth muscle. When given by rapid intravenous injection, it produces a rapid rise in blood pressure, mainly systolic, by (1) direct stimulation of cardiac muscle which increases the strength of ventricular contraction, (2) increasing the heart rate and (3) constriction of the arterioles in the skin, mucosa and splanchnic areas of the circulation. When given by slow intravenous injection, epinephrine usually produces only a moderate rise in systolic and a fall in diastolic pressure. Although some increase in pulse pressure occurs, there is usually no great elevation in mean blood pressure. Accordingly, the compensatory reflex mechanisms that come into play with a pronounced increase in blood pressure do not antagonize the direct cardiac actions of epinephrine as much as with catecholamines that have a predominant action on alpha receptors. Mechanism of action: Epinephrine works via the stimulation of alpha and beta-1 adrenergic receptors, and a moderate activity at beta-2 adrenergic receptors. Drug type: Approved. Small Molecule. Drug category: Adrenergic Agonists. Adrenergic alpha-Agonists. Adrenergic beta-Agonists. Bronchodilator Agents. Mydriatics. Sympathomimetics. Vasoconstrictor Agents . Sympathomimetics. Vasoconstrictor Agents
Has roleDrug  +, Hormone  +, and Neurotransmitter  +
IdDB00668  +
Is part ofCatecholamine system  +, Adrenergic system  +, and Noradrenergic system  +
LabelEpinephrine  +
ModifiedDate14 April 2014  +
RelatedToBeta-1 adrenergic receptor  +, Alpha-1A adrenergic receptor  +, Beta-2 adrenergic receptor  +, and Phenylalanine-4-hydroxylase  +
SuperCategoryMolecular entity  +
SynonymADR Adrenaline  +, Adrenalin  +, Adrenalin Chloride  +, Adrenalina  +, Adrenaline  +, Adrenalinum  +, D-Adrenaline  +, D-Epifrin  +, D-Epinephrine  +, Epinefrin (Czech)  +, Epinefrina (INN-Spanish)  +, Epinephran  +, Epinephrine Bitartrate  +, Epinephrinum (INN-Latin)  +, L-Adrenalin  +, L-Adrenaline  +, L-Adrenaline Base  +, L-Epinephine  +, L-Epinephrine  +, L-Epirenamine  +, Levoadrenaline  +, Levoepinephrine  +, Racepinefrina (inn-spanish)  +, Racepinefrine  +, Racepinefrinum (inn-latin)  +, Racepinephrine  +, ADROP  +, Adnephrine  +, Adrenal  +, Adrenalin-Medihaler  +, Adrenamine  +, Adrenan  +, Adrenapax  +, Adrenasol  +, Adrenatrate  +, Adrenine  +, Adrenodis  +, Adrenohorma  +, Adrenor  +, Adrenosan  +, Adrenutol  +, Adrin  +, Adrine  +, Aktamin  +, Ana-Guard  +, Antiasthmatique  +, Asmatane Mist  +, Asthma Meter Mist  +, Asthma-Nefrin  +, Asthmahaler Mist  +, Asthmanefrin  +, Astmahalin  +, Astminhal  +, Balmadren  +, Bernarenin  +, Biorenine  +, Bosmin  +, Brevirenin  +, Bronkaid  +, Bronkaid Mist  +, Bronkaid Suspension Mist  +, Chelafrin  +, Citanest Forte  +, Corisol  +, Drenamist  +, Duranest  +, Dylephrin  +, Epi EZ Pen Jr  +, Epifrin  +, Epiglaufrin  +, Epipen  +, Epipen Auto-Injector  +, Epipen EZ Pen  +, Epipen Jr  +, Auto-Injector  +, Epirenamine  +, Epirenan  +, Epirenin  +, Epitrate  +, Eppy  +, Esphygmogenina  +, Exadrin  +, Glaucon  +, Glaucosan  +, Glauposine  +, Glycirenan  +, Haemostasin  +, Haemostatin  +, Hektalin  +, Hemisine  +, Hemostasin  +, Hemostatin  +, Hypernephrin  +, Hyporenin  +, IOP  +, Intranefrin  +, Iontocaine  +, Isoptoepinal  +, Kidoline  +, Levonor  +, Levorenen  +, Levorenin  +, Levorenine  +, Lidocaton  +, Lyophrin  +, Medihaler-Epi  +, Metanephrin  +, Micronefrin  +, Mucidrina  +, Myosthenine  +, Mytrate  +, Nephridine  +, Nephron  +, Nieraline  +, Nor-Epirenan  +, Norartrinal  +, Paranephrin  +, Primatene Mist  +, Renagladin  +, Renaglandin  +, Renaglandulin  +, Renaleptine  +, Renalina  +, Renoform  +, Renostypricin  +, Renostypticin  +, Renostyptin  +, Scurenaline  +, Septocaine  +, Simplene  +, Sindrenina  +, Soladren  +, Sphygmogenin  +, Stryptirenal  +, Styptirenal  +, Supracapsulin  +, Supradin  +, Supranefran  +, Supranephrane  +, Supranephrine  +, Supranol  +, Suprarenaline  +, Suprarenin  +, Suprel  +, Surenine  +, Surrenine  +, Sus-Phrine  +, Susphrine  +, Sympathin E  +, Sympathin I  +, Takamina  +, Takamine  +, Tokamina  +, Tolansin  +, Tolax  +, Tolcil  +, Tolhart  +, Tonogen  +, Twinject  +, Vaponefrin  +, Vasoconstrictine  +, Vasodrine  +, Vasoton  +, and Vasotonin  +