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Fludarabine

Name: Fludarabine
Description: Fludarabine (marketed as fludarabine phosphate under the trade name Fludara) is a chemotherapy drug used in the treatment of hematological malignancies. (Wikipedia) Pharmacology: Fludarabine is a chemotherapy drug used in the treatment of chronic lymphocytic leukemia. It acts at DNA polymerase alpha, ribonucleotide reductase and DNA primase, results in the inhibition of DNA synthesis, and destroys the cancer cells. Mechanism of action: Fludarabine phosphate is rapidly dephosphorylated to 2-fluoro-ara-A and then phosphorylated intracellularly by deoxycytidine kinase to the active triphosphate, 2-fluoro-ara-ATP. This metabolite appears to act by inhibiting DNA polymerase alpha, ribonucleotide reductase and DNA primase, thus inhibiting DNA synthesis. The mechanism of action of this antimetabolite is not completely characterized and may be multi-faceted. Drug type: Approved. Small Molecule. Drug category: Antimetabolites. Antimetabolites, Antineoplastic. Antineoplastic Agents. Immunosuppressive Agents
Synonym(s): FAMP, Fludarabine 5'-monophosphate, Fludarabine monophosphate, Fludarabine phosphate, Fludara, Fludura
Related to: Apoptosis regulator Bcl-2, Ribonucleoside-diphosphate reductase large subunit, DNA polymerase alpha catalytic subunit, Signal transducer and activator of transcription 1-alpha/beta, Adenosine deaminase
Has role: Drug
Super-category: Molecular entity
URL: http://www.drugbank.ca/drugs/DB01073
Id: DB01073
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Commenttaken from DrugBank
CuratorAb  +
DefiningCitationhttp://www.drugbank.ca/drugs/DB01073  +
DefinitionFludarabine (marketed as fludarabine phosp Fludarabine (marketed as fludarabine phosphate under the trade name Fludara) is a chemotherapy drug used in the treatment of hematological malignancies. (Wikipedia) Pharmacology: Fludarabine is a chemotherapy drug used in the treatment of chronic lymphocytic leukemia. It acts at DNA polymerase alpha, ribonucleotide reductase and DNA primase, results in the inhibition of DNA synthesis, and destroys the cancer cells. Mechanism of action: Fludarabine phosphate is rapidly dephosphorylated to 2-fluoro-ara-A and then phosphorylated intracellularly by deoxycytidine kinase to the active triphosphate, 2-fluoro-ara-ATP. This metabolite appears to act by inhibiting DNA polymerase alpha, ribonucleotide reductase and DNA primase, thus inhibiting DNA synthesis. The mechanism of action of this antimetabolite is not completely characterized and may be multi-faceted. Drug type: Approved. Small Molecule. Drug category: Antimetabolites. Antimetabolites, Antineoplastic. Antineoplastic Agents. Immunosuppressive Agents eoplastic Agents. Immunosuppressive Agents
Has roleDrug  +
IdDB01073  +
LabelFludarabine  +
ModifiedDate14 April 2014  +
RelatedToApoptosis regulator Bcl-2  +, Ribonucleoside-diphosphate reductase large subunit  +, DNA polymerase alpha catalytic subunit  +, Signal transducer and activator of transcription 1-alpha/beta  +, and Adenosine deaminase  +
SuperCategoryMolecular entity  +
SynonymFAMP  +, Fludarabine 5'-monophosphate  +, Fludarabine monophosphate  +, Fludarabine phosphate  +, Fludara  +, and Fludura  +