EditFrom NeuroLex
Fludarabine
| Name: | Fludarabine |
| Description: | Fludarabine (marketed as fludarabine phosphate under the trade name Fludara) is a chemotherapy drug used in the treatment of hematological malignancies. (Wikipedia) Pharmacology: Fludarabine is a chemotherapy drug used in the treatment of chronic lymphocytic leukemia. It acts at DNA polymerase alpha, ribonucleotide reductase and DNA primase, results in the inhibition of DNA synthesis, and destroys the cancer cells. Mechanism of action: Fludarabine phosphate is rapidly dephosphorylated to 2-fluoro-ara-A and then phosphorylated intracellularly by deoxycytidine kinase to the active triphosphate, 2-fluoro-ara-ATP. This metabolite appears to act by inhibiting DNA polymerase alpha, ribonucleotide reductase and DNA primase, thus inhibiting DNA synthesis. The mechanism of action of this antimetabolite is not completely characterized and may be multi-faceted. Drug type: Approved. Small Molecule. Drug category: Antimetabolites. Antimetabolites, Antineoplastic. Antineoplastic Agents. Immunosuppressive Agents |
| Synonym(s): | FAMP, Fludarabine 5'-monophosphate, Fludarabine monophosphate, Fludarabine phosphate, Fludara, Fludura |
| Related to: | Apoptosis regulator Bcl-2, Ribonucleoside-diphosphate reductase large subunit, DNA polymerase alpha catalytic subunit, Signal transducer and activator of transcription 1-alpha/beta, Adenosine deaminase |
| Has role: | Drug |
| Super-category: | Molecule |
| URL: | http://www.drugbank.ca/drugs/DB01073 |
| Id: | DB01073 |
| Link to OWL / RDF: | Download this content as OWL/RDF |
Facts about FludarabineRDF feed
| Comment | taken from DrugBank |
| Curator | Ab + |
| DefiningCitation | http://www.drugbank.ca/drugs/DB01073 + |
| Definition | Fludarabine (marketed as fludarabine phosp … Fludarabine (marketed as fludarabine phosphate under the trade name Fludara) is a chemotherapy drug used in the treatment of hematological malignancies. (Wikipedia) Pharmacology: Fludarabine is a chemotherapy drug used in the treatment of chronic lymphocytic leukemia. It acts at DNA polymerase alpha, ribonucleotide reductase and DNA primase, results in the inhibition of DNA synthesis, and destroys the cancer cells. Mechanism of action: Fludarabine phosphate is rapidly dephosphorylated to 2-fluoro-ara-A and then phosphorylated intracellularly by deoxycytidine kinase to the active triphosphate, 2-fluoro-ara-ATP. This metabolite appears to act by inhibiting DNA polymerase alpha, ribonucleotide reductase and DNA primase, thus inhibiting DNA synthesis. The mechanism of action of this antimetabolite is not completely characterized and may be multi-faceted. Drug type: Approved. Small Molecule. Drug category: Antimetabolites. Antimetabolites, Antineoplastic. Antineoplastic Agents. Immunosuppressive Agents eoplastic Agents. Immunosuppressive Agents |
| Has role | Drug + |
| Id | DB01073 + |
| Label | Fludarabine + |
| ModifiedDate | 4 February 2010 + |
| RelatedTo | Apoptosis regulator Bcl-2 +, Ribonucleoside-diphosphate reductase large subunit +, DNA polymerase alpha catalytic subunit +, Signal transducer and activator of transcription 1-alpha/beta +, and Adenosine deaminase + |
| SuperCategory | Molecule + |
| Synonym | FAMP +, Fludarabine 5'-monophosphate +, Fludarabine monophosphate +, Fludarabine phosphate +, Fludara +, and Fludura + |