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Fluphenazine

Name: Fluphenazine
Description: A phenothiazine used in the treatment of psychoses. Its properties and uses are generally similar to those of chlorpromazine. (PubChem) Pharmacology: Fluphenazine is a trifluoro-methyl phenothiazine derivative intended for the management of schizophrenia and other psychotic disorders. Fluphenazine has not been shown effective in the management of behaviorial complications in patients with mental retardation. Mechanism of action: Fluphenazine blocks postsynaptic mesolimbic dopaminergic D1 and D2 receptors in the brain; depresses the release of hypothalamic and hypophyseal hormones and is believed to depress the reticular activating system thus affecting basal metabolism, body temperature, wakefulness, vasomotor tone, and emesis. Drug type: Approved. Small Molecule. Drug category: Antipsychotic Agents. Antipsychotics. Dopamine Antagonists. Phenothiazines
Synonym(s): Fluorfenazine, Fluorophenazine, Fluorphenazine, Fluphenazine Decanoate, Fluphenazine Hcl, Triflumethazine, Apo-Fluphenazine, Elinol, Modecate, Moditen Enanthate, Moditen Hcl, Permitil Concentrate, Prolixin, Prolixin Concentrate, Prolixin Enanthate, Prolixine, Sevinol, Siqualine, Siqualon, Vespazine, Yespazine
Has role: Drug
Super-category: Molecular entity
URL: http://www.drugbank.ca/drugs/DB00623
*Id: DB00623
Related to: D(1A) dopamine receptor, Calmodulin, D(2) dopamine receptor
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Facts about FluphenazineRDF feed
Commenttaken from DrugBank
CuratorAb  +
DefiningCitationhttp://www.drugbank.ca/drugs/DB00623  +
DefinitionA phenothiazine used in the treatment of p A phenothiazine used in the treatment of psychoses. Its properties and uses are generally similar to those of chlorpromazine. (PubChem) Pharmacology: Fluphenazine is a trifluoro-methyl phenothiazine derivative intended for the management of schizophrenia and other psychotic disorders. Fluphenazine has not been shown effective in the management of behaviorial complications in patients with mental retardation. Mechanism of action: Fluphenazine blocks postsynaptic mesolimbic dopaminergic D1 and D2 receptors in the brain; depresses the release of hypothalamic and hypophyseal hormones and is believed to depress the reticular activating system thus affecting basal metabolism, body temperature, wakefulness, vasomotor tone, and emesis. Drug type: Approved. Small Molecule. Drug category: Antipsychotic Agents. Antipsychotics. Dopamine Antagonists. Phenothiazines tics. Dopamine Antagonists. Phenothiazines
Has roleDrug  +
IdDB00623  +
LabelFluphenazine  +
ModifiedDate14 April 2014  +
RelatedToD(1A) dopamine receptor  +, Calmodulin  +, and D(2) dopamine receptor  +
SuperCategoryMolecular entity  +
SynonymFluorfenazine  +, Fluorophenazine  +, Fluorphenazine  +, Fluphenazine Decanoate  +, Fluphenazine Hcl  +, Triflumethazine  +, Apo-Fluphenazine  +, Elinol  +, Modecate  +, Moditen Enanthate  +, Moditen Hcl  +, Permitil Concentrate  +, Prolixin  +, Prolixin Concentrate  +, Prolixin Enanthate  +, Prolixine  +, Sevinol  +, Siqualine  +, Siqualon  +, Vespazine  +, and Yespazine  +