arrow

From NeuroLex

Jump to: navigation, search



Guaifenesin

Name: Guaifenesin
Description: An expectorant that also has some muscle relaxing action. It is used in many cough preparations. (PubChem) Pharmacology: Guaifenesin is an expectorant which increases the output of phlegm (sputum) and bronchial secretions by reducing adhesiveness and surface tension. The increased flow of less viscous secretions promotes ciliary action and changes a dry, unproductive cough to one that is more productive and less frequent. By reducing the viscosity and adhesiveness of secretions, guaifenesin increases the efficacy of the mucociliary mechanism in removing accumulated secretions from the upper and lower airway. Mechanism of action: Guaifenesin may act as an irritant to gastric vagal receptors, and recruit efferent parasympathetic reflexes that cause glandular exocytosis of a less viscous mucus mixture. Cough may be provoked. This combination may flush tenacious, congealed mucopurulent material from obstructed small airways and lead to a temporary improvement in dyspnea or the work of breathing. Drug type: Approved. Small Molecule. Drug category: Expectorants
Synonym(s): Glycerin guaiacolate, Glycerin monoguaiacol ether, Glycero-guaiacol ether, Glycerol guaiacolate, Glyceryl guaiacol, Glyceryl guaiacol ether, Glyceryl guaiacolate, Glyceryl guaiacolate ether, Glyceryl guaiacyl ether, Glyceryl guaicolate, Glyceryl guiacolate, Guiaphenesin, Metfenossidiolo, Methoxypropanediol, Methphenoxydiol, Metossipropandiolo, o-Methoxyphenyl glyceryl ether, Actifed-C, Aeronesin, Amonidren, Amonidrin, Anti-Tuss, Aresol, Balminil Expectorant, Benylin-E, Breonesin, Bronchol, Calmipan, Calmylin Expectorant, Colrex expectorant, Cortussin, Creson, Diabetic Tussin EX, Dilyn, Dorassin, Equicol, Fenesin, Flartussin, Gaiamar, Gee-Gee, Genatuss, Glycodex, Glycotuss, Glytuss, Gnaifenesin, Guaia-rom, Guaiacol glycerin ether, Guaiacol glycerol ether, Guaiacol glyceryl ether, Guaiacolglicerinetere, Guaiacuran, Guaiacurane, Guaiacyl glyceryl ether, Guaiamar, Guaianesin, Guaicol glycerine ether, Guaicol glyceryl ether, Guaiphenesin, Guaiphenesine, Guaiphesin, Guajacol-glycerinaether, Guajacuran, Guajamar, Guanar, Guayanesin, Guiatuss, Gvaja, Halotussin, Humibid L, A, Humibid Sprinkle, Hustodil, Hustosil, Hytuss, Hytuss-2X, Mintosyl, Miocaina, Miocurin, Miorelax, Mucinex, Mucostop, Muskurelax, Myocain, Myocaine, Myorelax, Myoscain, Myoscaine, Naldecon Senior EX, Neuroton, Neurotone, Oresol, Oreson, Organidin NR, Pneumomist, Propanosedyl, Reduton, Relaxil G, Relaxyl-G, Reorganin, Resil, Respenyl, Respil, Resyl, Ritussin, Robitussin, Scot-tussin Expectorant, Sinumist-SR, Sirotol, Tenntus, Tenntuss, Tolseron, Tolyn, Touro EX, Tulyl, Tulyn, Uni-tussin
Has role: Drug
Super-category: Molecular entity
URL: http://www.drugbank.ca/drugs/DB00874
*Id: DB00874
Link to OWL / RDF: Download this content as OWL/RDF


Contributors

Ccdbuser, Nifbot2



bookmark

*Note: Neurolex imports many terms and their ids from existing community ontologies, e.g., the Gene Ontology. Neurolex, however, is a dynamic site and any content beyond the identifier should not be presumed to reflect the content or views of the source ontology. Users should consult with the authoritative source for each ontology for current information.

Facts about GuaifenesinRDF feed
Commenttaken from DrugBank
CuratorAb  +
DefiningCitationhttp://www.drugbank.ca/drugs/DB00874  +
DefinitionAn expectorant that also has some muscle r An expectorant that also has some muscle relaxing action. It is used in many cough preparations. (PubChem) Pharmacology: Guaifenesin is an expectorant which increases the output of phlegm (sputum) and bronchial secretions by reducing adhesiveness and surface tension. The increased flow of less viscous secretions promotes ciliary action and changes a dry, unproductive cough to one that is more productive and less frequent. By reducing the viscosity and adhesiveness of secretions, guaifenesin increases the efficacy of the mucociliary mechanism in removing accumulated secretions from the upper and lower airway. Mechanism of action: Guaifenesin may act as an irritant to gastric vagal receptors, and recruit efferent parasympathetic reflexes that cause glandular exocytosis of a less viscous mucus mixture. Cough may be provoked. This combination may flush tenacious, congealed mucopurulent material from obstructed small airways and lead to a temporary improvement in dyspnea or the work of breathing. Drug type: Approved. Small Molecule. Drug category: Expectorants mall Molecule. Drug category: Expectorants
Has roleDrug  +
IdDB00874  +
LabelGuaifenesin  +
ModifiedDate14 April 2014  +
SuperCategoryMolecular entity  +
SynonymGlycerin guaiacolate  +, Glycerin monoguaiacol ether  +, Glycero-guaiacol ether  +, Glycerol guaiacolate  +, Glyceryl guaiacol  +, Glyceryl guaiacol ether  +, Glyceryl guaiacolate  +, Glyceryl guaiacolate ether  +, Glyceryl guaiacyl ether  +, Glyceryl guaicolate  +, Glyceryl guiacolate  +, Guiaphenesin  +, Metfenossidiolo  +, Methoxypropanediol  +, Methphenoxydiol  +, Metossipropandiolo  +, o-Methoxyphenyl glyceryl ether  +, Actifed-C  +, Aeronesin  +, Amonidren  +, Amonidrin  +, Anti-Tuss  +, Aresol  +, Balminil Expectorant  +, Benylin-E  +, Breonesin  +, Bronchol  +, Calmipan  +, Calmylin Expectorant  +, Colrex expectorant  +, Cortussin  +, Creson  +, Diabetic Tussin EX  +, Dilyn  +, Dorassin  +, Equicol  +, Fenesin  +, Flartussin  +, Gaiamar  +, Gee-Gee  +, Genatuss  +, Glycodex  +, Glycotuss  +, Glytuss  +, Gnaifenesin  +, Guaia-rom  +, Guaiacol glycerin ether  +, Guaiacol glycerol ether  +, Guaiacol glyceryl ether  +, Guaiacolglicerinetere  +, Guaiacuran  +, Guaiacurane  +, Guaiacyl glyceryl ether  +, Guaiamar  +, Guaianesin  +, Guaicol glycerine ether  +, Guaicol glyceryl ether  +, Guaiphenesin  +, Guaiphenesine  +, Guaiphesin  +, Guajacol-glycerinaether  +, Guajacuran  +, Guajamar  +, Guanar  +, Guayanesin  +, Guiatuss  +, Gvaja  +, Halotussin  +, Humibid L  +, A  +, Humibid Sprinkle  +, Hustodil  +, Hustosil  +, Hytuss  +, Hytuss-2X  +, Mintosyl  +, Miocaina  +, Miocurin  +, Miorelax  +, Mucinex  +, Mucostop  +, Muskurelax  +, Myocain  +, Myocaine  +, Myorelax  +, Myoscain  +, Myoscaine  +, Naldecon Senior EX  +, Neuroton  +, Neurotone  +, Oresol  +, Oreson  +, Organidin NR  +, Pneumomist  +, Propanosedyl  +, Reduton  +, Relaxil G  +, Relaxyl-G  +, Reorganin  +, Resil  +, Respenyl  +, Respil  +, Resyl  +, Ritussin  +, Robitussin  +, Scot-tussin Expectorant  +, Sinumist-SR  +, Sirotol  +, Tenntus  +, Tenntuss  +, Tolseron  +, Tolyn  +, Touro EX  +, Tulyl  +, Tulyn  +, and Uni-tussin  +