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Hippocampal neuron

Name: Hippocampal neuron
Description: Neuron whose soma lies in any part of the hippocampal formation
Super-category: Defined neuron class
*Id: nlx_cell_0912003
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Id Neurotransmitter Synonym Definition Located in
Dentate gyrus HICAP cell nlx_32288 GABA Hilar cell
Hilar neuron
"The Dentate gyrus HICAP cells (HIlar Commissural-Associational pathway related cells) are multipolar or triangular cells in the polymorphic layer with thin, aspiny dendrites that extend both within the hilus and within the molecular layer. the axons of these HICAP cells extend through the granule cell layer and branch profusely in the inner third of the molecular layer." Dentate gyrus
Dentate gyrus HIPP cell nlx_cell_091201 GABA "The Dentate gyrus HIPP cell (HIlar Perforant Path-associated cell) is an interneuron in the Hippocampal formation. It is a long-spined multipolar cell that is conspicuous of distribution of copious, long and often branched spines over its cell body and dendrites. The axonal plexus can extend as much as 3.5mm along the septotemporal axis of the dentate gyrus. Since inhibitory interneurons typically have aspiny dendrites and relatively local axonal plexuses, this long spined multipolar/HIPP cell is a very atypical interneuron". Dentate gyrus
Dentate gyrus IS-I cell nlx_cell_091203 GABA DG Interneuron-specific cell The IS (Interneuron-Specific) subpopulation of interneurons have axons that preferentially innervate other interneurons. The Dentate gyrus IS-I class interneurons are visualized by immunostaining for Calretinin (CR) and establish multiple symmetrical synapses on the dendrites and somata of other CR-positive IS-I cells, Calbindin (CB) containing interneurons, and VIP-positive basket cells, but they do not innervate PV-containing interneurons. The dendrites of Dentate gyrus IS I neurons appear in all layers of Dentate gyrus and more characteristic feature of these dendrites is that they form long dendrodendritic junctions with each other. Dentate gyrus
Dentate gyrus IS-II cell nlx_cell_091204 GABA DG Interneruon-specific II cell The IS (Interneuron-Specific) subpopulation of interneurons have axons that preferentially innervate other interneurons. The Dentate Gyrus IS-II class interneurons are visualized by immunostaining for Vasoactive Intestinal Polypeptide (VIP). The dendrites of Dentate gyrus IS-II cells are present in all layers of Dentate gyrus. Dentate gyrus
Dentate gyrus MOPP cell nlx_47009 GABA The Dentate Gyrus MOPP cell (molecular layer perforant path-associated cell) is a interneuron in hippocampal formation. It is located deep in the DG molecular layer, has a multipolar or triangular cell body and gives rise to an axon that produces a substantial terminal plexus largely limited to the outer two thirds of the DG molecular layer. Dentate gyrus
Dentate gyrus axo-axonic cell nlx_54328 GABA DG Chandelier cell Dentate gyrus
Dentate gyrus basket cell nlx_cell_100201 pyramidal basket cell Dentate gyrus
Dentate gyrus granule cell nifext_153 Glutamate Dentate gyrus granule neuron
Granule cell of dentate gyrus
Dentate granule cell
DG granule cell
The dentate gyrus granule cell is the only principal cell of the dentate gyrus. Dentate gyrus
Dentate gyrus hilar cell nlx_cell_20090727 GABA Dentate gyrus
Dentate gyrus mossy cell nlx_22799 Glutamate Mossy cell
Mossy neuron
Dentate gyrus mossy neuron
Excitatory polymorphic intrinsic neuron of the dentate gyrus hilus Dentate gyrus hilus
Dentate gyrus spiny CR cell nlx_78883 GABA DG Spiny CR immunoreactive cell
DG Spiny CR-positive interneurons
The DG spiny CR cells are present mostly in regions where mossy fibers have a high density, i.e., in the hilus of the dentate gyrus and in stratum lucidum of CA3 subfield. The dendrites and somata frequently possess numerous long hair-like spines that penetrate into bundles of mossy fibers. Dentate gyrus
Dentate gyrus trilaminar interneuron nlx_cell_100204 GABA Neuron with soma in the hilar region of the dentate gyrus. The dendritic arbor orientation and axon collateral distribution of this neuron resembles most the trilaminar neuron 0f CA1 region. The axon collaterals extend logitudinally into strata radiatum, pyramidale and oriens, some axon collaterals reaching the subiculum and a main branch entering the fimbria. The dendrites of these neurons run parallel with the pyramidal cell layer. Another special feature is these cells are calbindin-positive immunoreactive neurons. Dentate gyrus
Head direction cell nlx_144208 Head-direction cell Neurons which fire when an animal's head is facing in a particular direction of horizontal plane, regardless of location, behavior or position of body Postsubiculum
Anterior Thalamus
Lateral mammillary nucleus
Hippocampus (CA) pyramidal cell sao131261273 Hippocampal Pyramidal Neuron Hippocampus
Hippocampus CA1 IS-I neuron nlx_cell_100209 CA1 IS-I cell The IS (Interneuron-Specific) subpopulation of interneurons have axons that preferentially innervate other interneurons. The CA1 Interneuron Specific (IS) Type I cells is one of the many IS cell types from the CA1 region. The soma is located in stratum radiatum and pyramidale with dendrites spanning most layers and the axon innervating mainly calbindin positive and other calretinin positive cells (Acsady et al. 1996b; Gulyas et al. 1996). The possible expression of VIP by these cells is not known. CA1 stratum radiatum
CA1 stratum pyramidale
Hippocampus CA1 IS-II neuron nlx_cell_1006029 CA1 IS-II cell The IS (Interneuron-Specific) subpopulation of interneurons have axons that preferentially innervate other interneurons. The CA1 Interneuron Specific (IS) type II cell is VIP+. The soma was reported mainly in stratum radiatum and the border with lacunosum-moleculare, and the dendrites are mostly in stratum lacunosum-moleculare (Acsady et al. 1996b; Gulyas et al. 1996). The axon innervates mainly CCK/VIP positive basket cells (Acsady et al. 1996b; Gulyas et al. 1996). The possible expression of calretinin by these cells is not known. CA1 stratum radiatum
Hippocampus CA1 IS-III neuron nlx_36222 CA1 IS-III cell The IS (Interneuron-Specific) subpopulation of interneurons have axons that preferentially innervate other interneurons. CA1 Interneuron Specific (IS) type III cells are VIP+, calretinin+ and terminals mGluR7a+. The soma is located mainly in stratum pyramidale and radiatum with radial dendrites crossing most layers (Acsady et al. 1996a,b). The axon innervates mainly O-LM cells (Acsady et al. 1996a; Ferraguti et al. 2004) and terminals express high level of mGluR7a in the presynaptic active zone (Somogyi et al. 2003). CA1 stratum radiatum
CA1 stratum pyramidale
Hippocampus CA1 LM(R) PP neuron nlx_81310 CA1 lacunosum-moleculare radiatum perforant path associated cell
CA1 LM/R PP cell
CA1 LM PP cell
CA1 lacunosum-moleculare radiatum PP neuron is a type of CA1 interneuron which is associated with perforant pathway. The cell bodies of these cells are in stratum radiatum or at the border of stratum radiatum and lacunosum-moleculare. The dendritic field reaches the alveus and covers all layers (Hajos & Mody, 1997; Vida et al. 1998). CA1 stratum radiatum
Hippocampus CA1 basket cell nlx_cell_091205 GABA Hippocampal CA1 basket cell Hippocampus
CA1 alveus
CA1 stratum oriens
Hippocampus CA1 ivy neuron nlx_35220 GABA CA1 ivy cell
ivy cell
Ivy cells are highly abundant GABAergic interneurons when compared to basket, bistratified, or axo-axonic cells. "Ivy" cells are named after their dense and fine axons innervating mostly basal and oblique pyramidal cell dendrites. They express nitric oxide synthase, neuropeptide Y, and high levels of GABAa receptor aplha1 subunit and they are also identified as slow-spiking interneurons that regulate the excitability of pyramidal cell dendrites through slowly rising and decaying GABAergic inputs. CA1 stratum pyramidale
Hippocampus CA1 neurogliaform neuron nlx_cell_1006031 CA1 NG cells
NG cells
CA1 neurogliaform neuron is a GABAergic interneuron, these cells are positive for NPY and co-express the actin-binding protein alpha-actinin-2. They are not positive for PV and VIP. Characteristically these neurons has a round cell body and short, non-spiny dendrites that were arranged in a stellate patterns around the cell body, spatially localized to the SLM, and often enter the molecular layer of the dentate gyrus. The axons are branched profusely close to soma occupying greater area than dendrites, like dendrites axons also tend to occupy mainly the SLM, often traveling fairly long distances along the SLM axis and mostly even entering the neighboring molecular layer of the dentate gyrus. CA1 stratum lacunosum moleculare
Hippocampus CA1 oriens lacunosum moleculare neuron nlx_cell_091206 GABA CA1 O-LM interneuron CA1 Oriens Lacunosum Moleculare (O-LM) cell is a neuron, which is characterized as a non-pyramidal cell type and interneuron that is mostly immunoreactive to GABAergic markers with the soma and dendrites mainly located in the CA1 stratum oriens and alveus, and axons extend directly to the stratum lacunosum-moleculare, ramifying there to form a dense plexus, forming symmetrical inhibitory synapses with the distal apical dendrites of pyramidal neurons while receiving excitatory input from CA1 recurrent collaterals in a disynaptic, feedback manner. CA1 alveus
CA1 stratum oriens
Hippocampus CA1 pyramidal cell sao830368389 Glutamate Hippocampal CA1 Pyramidal Neuron
CA1 pyramidal neuron
Hippocampal CA1 pyramidal cell
Pyramidal neuron with a soma located in hippocampal area CA1. It receives input from Schaffer collaterals of CA3 pyramidal neurons, and sends its axon to the subiculum and entorhinal cortex. CA1 stratum pyramidale
Hippocampus CA1 stratum oriens neuron nlx_cell_090807 vertical cells (Lacaille and williams
1990)
CA1 stratum oriens neuron is a neuron, which is characterized as an interneuron by inhibiting pyramidal cells through the activation of GABAa (Traub et al., 1987a) with soma located in CA1 stratum orines and alveus, dendrites extending into all strata (Lacaille and williams, 1990) and axons covering a wide area in the transverse direction, projecting onto basal dendrites and soma of pyramidal cells and other interneurons (Lacaille et al., 1987) in the hippocampus. CA1 stratum oriens
CA1 alveus
Hippocampus CA1 trilaminar neuron nlx_27085 CA1 trilaminar cell The CA1 trilaminar neuron is a neuron that is characterized by its axon densely innervating three layers stratum oriens, pyramidale and radiatum (Sik et al. 1995) projecting to subiculum and possibly to other regions, while the soma and long horizontal dendrites are in stratum oriens with strong immunoreactivity for the m2 receptor in the somato-dendritic domain and intense presynaptic mGluR8a decoration. It must also be noted that the same name has been used for various other cells with axon in at least three laminae (Hajos & Mody, 1997; Pawelzik et al. 2002). However, for this particular cell class the axons project to subiculum and possibly to other brain areas as well. CA1 alveus
CA1 stratum oriens
Hippocampus CA2 basket cell broad nlx_cell_091207 GABA CA2 basket cell The CA2 basket cells are the largest group of interneurons whose vertically oriented dendrites extend across all layers from stratum oriens into stratum lacunosum-moleculare and whose axons ramify extensively in stratum pyramidale. The broad basket cells have significantly broader dendritic width, and axonal arbors than that of other types of CA2 basket cells or of CA1 basket cells. Hippocampus
CA2
Hippocampus CA2 basket cell narrow nlx_cell_091208 GABA CA2 basket cell The CA2 basket cells are the largest group of interneurons in the CA2 region whose vertically oriented dendrites extend across all layers from stratum oriens into stratum lacunosum-moleculare and whose axons ramify extensively in stratum pyramidale. The narrow basket cells are narrow and both dendrites and axons are confined to the region of origin. CA2 stratum pyramidale
Hippocampus CA2 bistratified cell broad nlx_cell_091209 GABA CA2 bistratified cell The CA2 bistratified cells have radially oriented dendrites that resemble CA1 bistratified cells, but they extend through stratum oriens and stratum radiatum without entering stratum lacunosum-moleculare. The broad CA2 bistratified cells have dendrites that extend horizontally into all three CA subfields. CA2 stratum pyramidale
Hippocampus CA2 bistratified cell narrow nlx_cell_091004 GABA CA2 bistratified cell A type of neuron found in hippocampal area CA2 characterized by radially oriented dendrites that resemble CA1 bistratified cells, but they extend through stratum oriens and stratum radiatum without entering stratum lacunosum-moleculare. The narrow CA2 bistratified cell dendrites and axons are more confined within the CA2 region. CA2 stratum pyramidale
Hippocampus CA2 pyramidal neuron nlx_cell_20090311 Glutamate CA2 pyramidal cell CA2 pyramidal cells are the primary excitatory cells of CA2 region of the hippocampus. These cells have shorter dendrites when compared to CA1 pyramidal cells. The axons arbors into stratum radiatum, as well as into stratum oriens of CA1, CA2 and CA3 regions. The CA2 pyramids are innervated by schaffer collaterals in stratum oriens and stratum radiatum and by input from entorhinal cortex in stratum lacunosum moleculare. CA2
Hippocampus CA3 IS-I cell nlx_cell_091210 GABA CA3 Interneuron-specific I cell The IS (Interneuron-Specific) subpopulation of interneurons have axons that preferentially innervate other interneurons. CA3 IS-I neurons are visualized for CR and occur in all subfields of hippocampus and dentate gyrus. The CA3 IS-I cells has soma located in strata radiatum, oriens and pyramidale. The dendritic tree arborizes extensively in stratum radiatum but may also invade other layers. The characteristic feature of these dendrites is that they from long dendrodendritic junctions with each other. The main axons ramify in stratum radiatum, where they emit several collaterals that course in all directions. CA3 alveus
CA3 stratum oriens
CA3 stratum radiatum
CA3 stratum pyramidale
Hippocampus CA3 IS-II cell nlx_cell_091211 GABA CA3 interneuron-specific II cell The IS (Interneuron-Specific) subpopulation of interneurons have axons that preferentially innervate other interneurons. CA3 IS-II cell type is visualized by immunostaining for VIP. IS-II neurons are characterized in hippocampus alone, where their somata are found in stratum radiatum. The dendritic tree consists of a tuft of smooth or sparsely spiny dendrites restricted to stratum lacunosum-moleculare, where they profusely arborize. The axon descends toward stratum pyramidale, thus forming weeping willowlike arbor. CA3 stratum radiatum
Hippocampus CA3 axo-axonic cell nlx_cell_091212 GABA CA3 chandelier cell CA3 Chandelier cells of the hippocampus are very similar to those in the dentate gyrus. The cell bodies are located within or immediately adjacent to the pyramidal cell layer and possess radially oriented dendrites spanning all layers. According to the distribution of the dendritic tree, chandelier cells are in a position to receive excitatory input from all major sources of afferents in both the CA1 and CA3 subfields. CA3 stratum pyramidale
Hippocampus CA3 basket cell nlx_cell_091213 GABA CA3 pyramidal basket cell The CA3 basket cell is an interneuron located in hippocampus area CA3 characterized by a triangular or fusiform soma, with one to three dendrites extending from the cell soma. One of the three dendrites originate from the apical pole of soma, which then branch profusely, ascend through stratum radiatum, and often penetrate stratum lacunosum-moelculare. Primary basal dendrites are more numerous. They also branch close to soma and fan out toward the alveus, spanning the entire depth of stratum oriens. CA3 stratum pyramidale
Hippocampus CA3 lacunosum moleculare neuron nlx_cell_091214 GABA CA3 LM interneurons The CA3 Lacunosum Moleculare (LM) neurons are interneurons with somata in stratum lacunosum-moleculare that receive converging stimulation from the DG and entorhinal cortex as well as from within CA3. These LM neurons have dendrites that are oriented horizontally within the layer but occasionally have branches that extend into the pyramidal cell layer. The axon also takes a predominantly horizontal orientation and ramifies mainly in the stratum lacunosum-moleculare or superficial layer portion of the stratum radiatum. CA3 stratum lacunosum moleculare
Hippocampus CA3 oriens lacunosum moleculare neuron nlx_cell_091216 GABA OLM cell OLM cells (oriens/lacunosum-moleculare associated cell) has as its defining feature a dense axonal arbor that is confined to the stratum lacunosum-moleculare (also known as cells terminating in conjunction with entorhinal afferents). In principle the cell body and dendritic trees are located in the zones occupied by recurrent pyramidal cell collaterals. In CA3 this includes all strata except the stratum oriens. CA3 stratum oriens
CA3 alveus
Hippocampus CA3 pyramidal cell sao383526650 Glutamate Hippocampal CA3 Pyramidal Neuron
CA3 pyramidal neuron
CA3 pyramidal cell
This is the major output neuron in area CA3 of the hippocampus. It receives input from mossy fibers of the dentate gyrus. Its axon projects to the contralateral hippocampus and subcortically to the septal nucleus, and sends axon collaterals called Shaffer collaterals to the nearby CA1 region. CA3 stratum pyramidale
Hippocampus CA3 radiatum neuron nlx_cell_091217 GABA CA3 R interneuron The CA3 Radiatum (R) neurons are interneurons with somata in stratum radiatum which receives converging stimulation from the DG and entorhinal cortex as well as from within CA3. The dendritic tree of R interneurons typically extend between the dorsal blade of the dentate gyrus and the stratum pyramidale of CA3. The axonal branches often extend beyond their layer of somatic residence into stratum lacunosum-moleculare or stratum pyramidale. CA3 stratum radiatum
Hippocampus CA3 spiny CR cell nlx_cell_091218 GABA CA3 Spiny CR immunoreactive cell
CA3 Spiny CR-positive interneurons
The CA3 spiny CR cell is an interneuron in Hippocampus that is present mostly in regions where mossy fibers have a high density, i.e., in the hilus of the dentate gyrus and in stratum lucidum of CA3 subfield. The dendrites and somata frequently possess numerous long hair-like spines that penetrate into bundles of mossy fibers. CA3 stratum lucidum
Subiculum pyramidal cell nifext_159 Glutamate Subiculum pyramidal neuron Pyramidal neuron whose cell body is located in the subiculum Subiculum

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*Note: Neurolex imports many terms and their ids from existing community ontologies, e.g., the Gene Ontology. Neurolex, however, is a dynamic site and any content beyond the identifier should not be presumed to reflect the content or views of the source ontology. Users should consult with the authoritative source for each ontology for current information.

Facts about Hippocampal neuronRDF feed
CurationStatusuncurated  +
DefinitionNeuron whose soma lies in any part of the hippocampal formation
Idnlx_cell_0912003  +
LabelHippocampal neuron  +
ModifiedDate8 May 2010  +
SuperCategoryDefined neuron class  +