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Interferon alfa-n1
| Name: | Interferon alfa-n1 |
| Description: | Purified, natural (n is for natural) glycosylated human interferon alpha proteins 166 residues Pharmacology: Upregulates the expression of MHC I proteins, allowing for increased presentation of peptides derived from viral antigens. This enhances the activation of CD8+ T cells that are the precursors for cytotoxic T lymphocytes (CTLs) and makes the macrophage a better target for CTL-mediated killing. Interferon alpha also induce the synthesis of several key antiviral mediators, including 2'-5' oligoadenylate synthetase (2'-5' A synthetase) and protein kinase R. Mechanism of action: Interferon alpha binds to type I interferon receptors (IFNAR1 and IFNAR2c) which, upon dimerization, activate two Jak (Janus kinase) tyrosine kinases (Jak1 and Tyk2). These transphosphorylate themselves and phosphorylate the receptors. The phosphorylated INFAR receptors then bind to Stat1 and Stat2 (signal transducers and activators of transcription)which dimerize and activate multiple (~100) immunomodulatory and antiviral proteins. Interferon alpha binds less stably to type I interferon receptors than interferon beta. Drug type: Approved. Biotech. Drug category: Antiviral Agents. Immunomodulatory Agents |
| Synonym(s): | Interferon alpha-2, Interferon alpha-A, LeIF A, Wellferon (GlaxoSmithKline) |
| Related to: | Interferon-alpha/beta receptor beta chain, Interferon-alpha/beta receptor alpha chain |
| Has role: | Drug |
| Super-category: | Molecule |
| URL: | http://www.drugbank.ca/drugs/DB00011 |
| Id: | DB00011 |
| Link to OWL / RDF: | Download this content as OWL/RDF |
Facts about Interferon alfa-n1RDF feed
| Comment | taken from DrugBank |
| Curator | Ab + |
| DefiningCitation | http://www.drugbank.ca/drugs/DB00011 + |
| Definition | Purified, natural (n is for natural) glyco … Purified, natural (n is for natural) glycosylated human interferon alpha proteins 166 residues Pharmacology: Upregulates the expression of MHC I proteins, allowing for increased presentation of peptides derived from viral antigens. This enhances the activation of CD8+ T cells that are the precursors for cytotoxic T lymphocytes (CTLs) and makes the macrophage a better target for CTL-mediated killing. Interferon alpha also induce the synthesis of several key antiviral mediators, including 2'-5' oligoadenylate synthetase (2'-5' A synthetase) and protein kinase R. Mechanism of action: Interferon alpha binds to type I interferon receptors (IFNAR1 and IFNAR2c) which, upon dimerization, activate two Jak (Janus kinase) tyrosine kinases (Jak1 and Tyk2). These transphosphorylate themselves and phosphorylate the receptors. The phosphorylated INFAR receptors then bind to Stat1 and Stat2 (signal transducers and activators of transcription)which dimerize and activate multiple (~100) immunomodulatory and antiviral proteins. Interferon alpha binds less stably to type I interferon receptors than interferon beta. Drug type: Approved. Biotech. Drug category: Antiviral Agents. Immunomodulatory Agents Antiviral Agents. Immunomodulatory Agents |
| Has role | Drug + |
| Id | DB00011 + |
| Label | Interferon alfa-n1 + |
| ModifiedDate | 5 February 2010 + |
| RelatedTo | Interferon-alpha/beta receptor beta chain +, and Interferon-alpha/beta receptor alpha chain + |
| SuperCategory | Molecule + |
| Synonym | Interferon alpha-2 +, Interferon alpha-A +, LeIF A +, and Wellferon (GlaxoSmithKline) + |