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Loxapine

Name: Loxapine
Description: An antipsychotic agent used in schizophrenia. (PubChem) Pharmacology: Loxapine, a dibenzoxazepine compound, represents a subclass of tricyclic antipsychotic agents, chemically distinct from the thioxanthenes, butyrophenones, and phenothiazines. Pharmacologically, Loxapine is a tranquilizer for which the exact mode of action has not been established. Mechanism of action: Loxapine is a dopamine antagonist, and also a serotonin 5-HT2 blocker. The exact mode of action of Loxapine has not been established, however changes in the level of excitability of subcortical inhibitory areas have been observed in several animal species in association with such manifestations of tranquilization as calming effects and suppression of aggressive behavior. Drug type: Approved. Small Molecule. Drug category: Antipsychotic Agents. Antipsychotics. Dopamine Antagonists
Synonym(s): Cloxazepine, Dibenzacepin, Dibenzoazepine, Hydrofluoride 3170, Lossapina (Dcit), Loxapac, Loxapin, Loxapina (INN-Spanish), Loxapine (Usan:Ban:Inn), Loxapinum (INN-Latin), Loxepine, Loxitane C, Loxitane Im, Oxilapine
Has role: Drug
Super-category: Molecular entity
URL: http://www.drugbank.ca/drugs/DB00408
*Id: CHEBI:50841
Related to: D(1A) dopamine receptor, D(2) dopamine receptor
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Bandrow, Ccdbuser, Nifbot2, Whetzel



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*Note: Neurolex imports many terms and their ids from existing community ontologies, e.g., the Gene Ontology. Neurolex, however, is a dynamic site and any content beyond the identifier should not be presumed to reflect the content or views of the source ontology. Users should consult with the authoritative source for each ontology for current information.

Facts about LoxapineRDF feed
Commenttaken from DrugBank
CurationStatusuncurated  +
CuratorAb  +
DefiningCitationhttp://www.drugbank.ca/drugs/DB00408  +
DefinitionAn antipsychotic agent used in schizophren An antipsychotic agent used in schizophrenia. (PubChem) Pharmacology: Loxapine, a dibenzoxazepine compound, represents a subclass of tricyclic antipsychotic agents, chemically distinct from the thioxanthenes, butyrophenones, and phenothiazines. Pharmacologically, Loxapine is a tranquilizer for which the exact mode of action has not been established. Mechanism of action: Loxapine is a dopamine antagonist, and also a serotonin 5-HT2 blocker. The exact mode of action of Loxapine has not been established, however changes in the level of excitability of subcortical inhibitory areas have been observed in several animal species in association with such manifestations of tranquilization as calming effects and suppression of aggressive behavior. Drug type: Approved. Small Molecule. Drug category: Antipsychotic Agents. Antipsychotics. Dopamine Antagonists ents. Antipsychotics. Dopamine Antagonists
Has roleDrug  +
IdCHEBI:50841  +
LabelLoxapine  +
ModifiedDate31 July 2014  +
RelatedToD(1A) dopamine receptor  +, and D(2) dopamine receptor  +
SuperCategoryMolecular entity  +
SynonymCloxazepine  +, Dibenzacepin  +, Dibenzoazepine  +, Hydrofluoride 3170  +, Lossapina (Dcit)  +, Loxapac  +, Loxapin  +, Loxapina (INN-Spanish)  +, Loxapine (Usan:Ban:Inn)  +, Loxapinum (INN-Latin)  +, Loxepine  +, Loxitane C  +, Loxitane Im  +, and Oxilapine  +