arrow

From NeuroLex

Jump to: navigation, search



Melatonin

Name: Melatonin
Description: A biogenic amine that is found in animals and plants. In mammals, melatonin is produced by the pineal gland. Its secretion increases in darkness and decreases during exposure to light. Melatonin is implicated in the regulation of sleep, mood, and reproduction. Melatonin is also an effective antioxidant. (PubChem) Pharmacology: Melatonin is a hormone normally produced in the pineal gland and released into the blood. The essential amino acid L-tryptophan is a precursor in the synthesis of melatonin. It helps regulate sleep-wake cycles or the circadian rhythm. Production of melatonin is stimulated by darkness and inhibited by light. High levels of melatonin induce sleep and so consumption of the drug can be used to combat insomnia and jet lag. Mechanism of action: Melatonin is a derivative of tryptophan. It binds to melatonin receptor type 1A, which then acts on adenylate cylcase and the inhibition of a cAMP signal transduction pathway. Melatonin not only inhibits adenylate cyclase, but it also activates phosphilpase C. This potentiates the release of arachidonate. Drug type: Approved. Small Molecule. Drug category: Adjuvants, Immunologic. Anticonvulsants. Antioxidants. Central Nervous System Depressants. Free Radical Scavengers
Synonym(s): Circadin, MT6, Mela-T, Melatol, Melatonex, Melatonine, Melovine, Night Rest
Has role: Drug, hormone
Super-category: Molecule
URL: http://www.drugbank.ca/drugs/DB01065
Id: CHEBI_16796
Related to: Estrogen receptor, Apoptosis regulator Bcl-2, Melatonin receptor type 1A, Alpha-synuclein, Cytochrome c, Caspase-3, pineal body
Link to OWL / RDF: Download this content as OWL/RDF




bookmark
Facts about MelatoninRDF feed
Commenttaken from DrugBank
CurationStatusuncurated  +
CuratorAb  +
DefiningCitationhttp://www.drugbank.ca/drugs/DB01065  +
DefinitionA biogenic amine that is found in animals A biogenic amine that is found in animals and plants. In mammals, melatonin is produced by the pineal gland. Its secretion increases in darkness and decreases during exposure to light. Melatonin is implicated in the regulation of sleep, mood, and reproduction. Melatonin is also an effective antioxidant. (PubChem) Pharmacology: Melatonin is a hormone normally produced in the pineal gland and released into the blood. The essential amino acid L-tryptophan is a precursor in the synthesis of melatonin. It helps regulate sleep-wake cycles or the circadian rhythm. Production of melatonin is stimulated by darkness and inhibited by light. High levels of melatonin induce sleep and so consumption of the drug can be used to combat insomnia and jet lag. Mechanism of action: Melatonin is a derivative of tryptophan. It binds to melatonin receptor type 1A, which then acts on adenylate cylcase and the inhibition of a cAMP signal transduction pathway. Melatonin not only inhibits adenylate cyclase, but it also activates phosphilpase C. This potentiates the release of arachidonate. Drug type: Approved. Small Molecule. Drug category: Adjuvants, Immunologic. Anticonvulsants. Antioxidants. Central Nervous System Depressants. Free Radical Scavengers ystem Depressants. Free Radical Scavengers
Has roleDrug  +, and Hormone  +
IdCHEBI_16796  +
LabelMelatonin  +
ModifiedDate12 March 2013  +
RelatedToEstrogen receptor  +, Apoptosis regulator Bcl-2  +, Melatonin receptor type 1A  +, Alpha-synuclein  +, Cytochrome c  +, Caspase-3  +, and Pineal body  +
SuperCategoryMolecule  +
SynonymCircadin  +, MT6  +, Mela-T  +, Melatol  +, Melatonex  +, Melatonine  +, Melovine  +, and Night Rest  +