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Meprobamate

Name: Meprobamate
Description: A carbamate with hypnotic, sedative, and some muscle relaxant properties, although in therapeutic doses reduction of anxiety rather than a direct effect may be responsible for muscle relaxation. Meprobamate has been reported to have anticonvulsant actions against petit mal seizures, but not against grand mal seizures (which may be exacerbated). It is used in the treatment of anxiety disorders, and also for the short-term management of insomnia but has largely been superseded by the benzodiazepines. (From Martindale, The Extra Pharmacopoeia, 30th ed, p603) Meprobamate is a controlled substance in the U.S. Pharmacology: Meprobamate is an anxiolytic drug. It was the best selling minor tranquilizer for a time but has largely been replaced by benzodiazepines. Meprobamate has most of the pharmacological effects and dangers of the barbiturates (though it was marketed as being safer). However, it is less sedating at effective doses. It is reported to have some anticonvulsant properties against absence seizures, but can exacerbate generalized tonic-clonic seizures. It has also been used as a hypnotic (sleeping pill). However, its is currently only licensed as an anxiolytic and it is a third or fourth-order choice. Mechanism of action: Meprobamate's mechanism of action is not known. It has been shown in animal studies to have effects at multiple sites in the central nervous system, including the thalamus and limbic system. Meprobamate binds to GABAA receptors which interrupt neuronal communication in the reticular formation and spinal cord, causing sedation and altered perception of pain. Drug type: Approved. Illicit. Small Molecule. Drug category: Anti-anxiety Agents. Anticonvulsants. Hypnotics and Sedatives. Muscle Relaxants, Central
Synonym(s): DEA No, 2820, Meprobamat (German), Meprobamato (INN-Spanish), Meprobamato (Italian), Meprobamatum (INN-Latin), Meprobamic acid, Procarbamide, 3P bamate, Amepromat, Amosene, Anastress, Anathylmon, Anatimon, Andaksin, Andaxin, Aneural, Aneurol, Aneusral, Aneuxal, Aneuxral, Ansiatan, Ansietan, Ansil, Ansiowas, Anural, Anxietil, Anzil, Apascil, Apasil, Apo-Meprobamate, Appetrol, Appetrol-Sr, Arcoban, Arpon, Artolon, Ataraxine, Atraxin, Auxietil, Ayeramate, Ayermate, Bamate, Bamd 400, Bamo 400, Biobamat, Biobamate, Brobamate, Calmadin, Calmax, Calmiren, Canquil 400, Canquil-400, Carbaxin, Cirpon, Cirponyl, Coprobate, Crestanil, Cypron, Cyrpon, Dapaz, Deprol, Despasmol, Dicandiol, Diron, Diurnal, Diveron, Dormabrol, Ecuanil, Edenal, Enorden, Epicur, Epikur, Equagesic, Equanil, Equatrate, Equazine-M, Equilium, Equinil, Equitar, Erina, Estasil, Fas-Cile, Fas-Cile 200, Gadexyl, Gagexyl, Harmonin, Hartol, Holbamate, Ipsotian, Kesso-Bamate, Kessobamate, Klort, Larten, Lepenil, Lepetown, Letyl, Libiolan, Madiol, Mar-Bate, Margonil, Mendel, Mepamtin, Mepantin, Mepavlon, Mepiosine, Meposed, Mepranil, Mepriam, Meprin, Meprindon, Mepro-Aspirin, Mepro-analgesic, Meprobam, Meprobamat, Meproban, Meprocompren, Meprocon, Meprocon CMC, Meprodil, Meprodiol, Meprol, Meproleaf, Mepron, Mepronil, Meprosa, Meprosan, Meprosin, Meprospan, Meprotabs, Meprotan, Meprotanum, Meproten, Meprotil, Meprovan, Meprozine, Meptran, Mesmar, Metractyl, Metranquil, Micrainin, Milpath, Milprem, Miltamato, Miltann, Miltaun, Miltown, Miltrate, Miltuan, Miltwon, Misedant, Morbam, Multaun, My-trans, Neo-Tran, Nephentine, Nervonus, Neuramate, Oasil, Optarket, Orlevol, Orolevol, Pan-tranquil, Pancalma, Panediol, Pankalma, Pathibamate, Paxin, Pensive, Perequietil, Perequil, Perquietil, Pertranquil, Pimal, Placidon, Placitate, Prequil, Probamato, Probamyl, Probate, Procalmadiol, Procalmadol, Procalmidol, Promate, Promato, Proquanil, Protran, Q-Gesic, Quaname, Quanane, Quanil, Quietidon, Quivet, Rastenil, Reostral, Restenil, Restenyl, Restinal, Restinil, Restran, Robamate, SK-Bamate, Sadanyl, Scolazil, Sedabamate, Sedanil, Sedanyl, Sedazil, Sedoquil, Sedoselecta, Selene, Seril, Setran, Shalvaton, Solevione anastress, Sowell, Spantran, Stensolo, Tamate, Tensol, Tensonal, Trancot, Trankvilan, Tranlisant, Tranmep, Tranquil, Tranquilan, Tranquilate, Tranquilax, Tranquiline, Tranquillin, Tranquilsan, Tranquinol, Tranquisan, Trelmar, Urbil, Urbilat, Vio-Bamate, Vistabamate, Wardamate, Wyseals, Zirpon
Has role: Drug
Super-category: Molecular entity
URL: http://www.drugbank.ca/drugs/DB00371
Id: DB00371
Related to: Gamma-aminobutyric-acid receptor subunit alpha-2, Gamma-aminobutyric-acid receptor subunit alpha-5, Gamma-aminobutyric-acid receptor subunit alpha-4, Gamma-aminobutyric-acid receptor subunit alpha-3, Gamma-aminobutyric-acid receptor subunit alpha-6, Gamma-aminobutyric-acid receptor subunit alpha-1
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Commenttaken from DrugBank
CuratorAb  +
DefiningCitationhttp://www.drugbank.ca/drugs/DB00371  +
DefinitionA carbamate with hypnotic, sedative, and s A carbamate with hypnotic, sedative, and some muscle relaxant properties, although in therapeutic doses reduction of anxiety rather than a direct effect may be responsible for muscle relaxation. Meprobamate has been reported to have anticonvulsant actions against petit mal seizures, but not against grand mal seizures (which may be exacerbated). It is used in the treatment of anxiety disorders, and also for the short-term management of insomnia but has largely been superseded by the benzodiazepines. (From Martindale, The Extra Pharmacopoeia, 30th ed, p603) Meprobamate is a controlled substance in the U.S. Pharmacology: Meprobamate is an anxiolytic drug. It was the best selling minor tranquilizer for a time but has largely been replaced by benzodiazepines. Meprobamate has most of the pharmacological effects and dangers of the barbiturates (though it was marketed as being safer). However, it is less sedating at effective doses. It is reported to have some anticonvulsant properties against absence seizures, but can exacerbate generalized tonic-clonic seizures. It has also been used as a hypnotic (sleeping pill). However, its is currently only licensed as an anxiolytic and it is a third or fourth-order choice. Mechanism of action: Meprobamate's mechanism of action is not known. It has been shown in animal studies to have effects at multiple sites in the central nervous system, including the thalamus and limbic system. Meprobamate binds to GABAA receptors which interrupt neuronal communication in the reticular formation and spinal cord, causing sedation and altered perception of pain. Drug type: Approved. Illicit. Small Molecule. Drug category: Anti-anxiety Agents. Anticonvulsants. Hypnotics and Sedatives. Muscle Relaxants, Central s and Sedatives. Muscle Relaxants, Central
Has roleDrug  +
IdDB00371  +
LabelMeprobamate  +
ModifiedDate14 April 2014  +
RelatedToGamma-aminobutyric-acid receptor subunit alpha-2  +, Gamma-aminobutyric-acid receptor subunit alpha-5  +, Gamma-aminobutyric-acid receptor subunit alpha-4  +, Gamma-aminobutyric-acid receptor subunit alpha-3  +, Gamma-aminobutyric-acid receptor subunit alpha-6  +, and Gamma-aminobutyric-acid receptor subunit alpha-1  +
SuperCategoryMolecular entity  +
SynonymDEA No  +, 2820  +, Meprobamat (German)  +, Meprobamato (INN-Spanish)  +, Meprobamato (Italian)  +, Meprobamatum (INN-Latin)  +, Meprobamic acid  +, Procarbamide  +, 3P bamate  +, Amepromat  +, Amosene  +, Anastress  +, Anathylmon  +, Anatimon  +, Andaksin  +, Andaxin  +, Aneural  +, Aneurol  +, Aneusral  +, Aneuxal  +, Aneuxral  +, Ansiatan  +, Ansietan  +, Ansil  +, Ansiowas  +, Anural  +, Anxietil  +, Anzil  +, Apascil  +, Apasil  +, Apo-Meprobamate  +, Appetrol  +, Appetrol-Sr  +, Arcoban  +, Arpon  +, Artolon  +, Ataraxine  +, Atraxin  +, Auxietil  +, Ayeramate  +, Ayermate  +, Bamate  +, Bamd 400  +, Bamo 400  +, Biobamat  +, Biobamate  +, Brobamate  +, Calmadin  +, Calmax  +, Calmiren  +, Canquil 400  +, Canquil-400  +, Carbaxin  +, Cirpon  +, Cirponyl  +, Coprobate  +, Crestanil  +, Cypron  +, Cyrpon  +, Dapaz  +, Deprol  +, Despasmol  +, Dicandiol  +, Diron  +, Diurnal  +, Diveron  +, Dormabrol  +, Ecuanil  +, Edenal  +, Enorden  +, Epicur  +, Epikur  +, Equagesic  +, Equanil  +, Equatrate  +, Equazine-M  +, Equilium  +, Equinil  +, Equitar  +, Erina  +, Estasil  +, Fas-Cile  +, Fas-Cile 200  +, Gadexyl  +, Gagexyl  +, Harmonin  +, Hartol  +, Holbamate  +, Ipsotian  +, Kesso-Bamate  +, Kessobamate  +, Klort  +, Larten  +, Lepenil  +, Lepetown  +, Letyl  +, Libiolan  +, Madiol  +, Mar-Bate  +, Margonil  +, Mendel  +, Mepamtin  +, Mepantin  +, Mepavlon  +, Mepiosine  +, Meposed  +, Mepranil  +, Mepriam  +, Meprin  +, Meprindon  +, Mepro-Aspirin  +, Mepro-analgesic  +, Meprobam  +, Meprobamat  +, Meproban  +, Meprocompren  +, Meprocon  +, Meprocon CMC  +, Meprodil  +, Meprodiol  +, Meprol  +, Meproleaf  +, Mepron  +, Mepronil  +, Meprosa  +, Meprosan  +, Meprosin  +, Meprospan  +, Meprotabs  +, Meprotan  +, Meprotanum  +, Meproten  +, Meprotil  +, Meprovan  +, Meprozine  +, Meptran  +, Mesmar  +, Metractyl  +, Metranquil  +, Micrainin  +, Milpath  +, Milprem  +, Miltamato  +, Miltann  +, Miltaun  +, Miltown  +, Miltrate  +, Miltuan  +, Miltwon  +, Misedant  +, Morbam  +, Multaun  +, My-trans  +, Neo-Tran  +, Nephentine  +, Nervonus  +, Neuramate  +, Oasil  +, Optarket  +, Orlevol  +, Orolevol  +, Pan-tranquil  +, Pancalma  +, Panediol  +, Pankalma  +, Pathibamate  +, Paxin  +, Pensive  +, Perequietil  +, Perequil  +, Perquietil  +, Pertranquil  +, Pimal  +, Placidon  +, Placitate  +, Prequil  +, Probamato  +, Probamyl  +, Probate  +, Procalmadiol  +, Procalmadol  +, Procalmidol  +, Promate  +, Promato  +, Proquanil  +, Protran  +, Q-Gesic  +, Quaname  +, Quanane  +, Quanil  +, Quietidon  +, Quivet  +, Rastenil  +, Reostral  +, Restenil  +, Restenyl  +, Restinal  +, Restinil  +, Restran  +, Robamate  +, SK-Bamate  +, Sadanyl  +, Scolazil  +, Sedabamate  +, Sedanil  +, Sedanyl  +, Sedazil  +, Sedoquil  +, Sedoselecta  +, Selene  +, Seril  +, Setran  +, Shalvaton  +, Solevione anastress  +, Sowell  +, Spantran  +, Stensolo  +, Tamate  +, Tensol  +, Tensonal  +, Trancot  +, Trankvilan  +, Tranlisant  +, Tranmep  +, Tranquil  +, Tranquilan  +, Tranquilate  +, Tranquilax  +, Tranquiline  +, Tranquillin  +, Tranquilsan  +, Tranquinol  +, Tranquisan  +, Trelmar  +, Urbil  +, Urbilat  +, Vio-Bamate  +, Vistabamate  +, Wardamate  +, Wyseals  +, and Zirpon  +