Metabotropic Glutamate Receptor

Current revision (unreviewed)

Name:	Metabotropic Glutamate Receptor
Description:	The metabotropic glutamate receptors, or mGluRs, are a type of glutamate receptor which are active through an indirect metabotropic process. They are members of the group C family of G-protein-coupled receptors, or GPCRs, and are divided into 3 groups based on sequence homology and binding affinities. Like all glutamate receptors, mGluRs bind to glutamate, an amino acid that functions as an excitatory neurotransmitter. Group I mGluR's are coupled to phospholipid metabolism and comprise members 1 and 5 Group II mGluR's are coupled to reduced cAMP turnover and comprise members 2, 3 and 4 Group III mGluR's are coupled to reduced cAMP turnover and comprise members 6, 7, and 8
Synonym(s):	mGluRs, GRM, Glutamate metabotropic, Metabotropic glutamate
Related to:	Glutamate, Aspartate
Has role:	Glutamate receptor
Abbreviation:	mGluR
Super-category:	G-protein_coupled_receptor
Id:	nlx_mol_20090503
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Contributors

This category has the following 9 subcategories, out of 9 total.

Abbrev	mGluR +
CurationStatus	uncurated +
Definition	The metabotropic glutamate receptors, or m … The metabotropic glutamate receptors, or mGluRs, are a type of glutamate receptor which are active through an indirect metabotropic process. They are members of the group C family of G-protein-coupled receptors, or GPCRs, and are divided into 3 groups based on sequence homology and binding affinities. Like all glutamate receptors, mGluRs bind to glutamate, an amino acid that functions as an excitatory neurotransmitter. Group I mGluR's are coupled to phospholipid metabolism and comprise members 1 and 5 Group II mGluR's are coupled to reduced cAMP turnover and comprise members 2, 3 and 4 Group III mGluR's are coupled to reduced cAMP turnover and comprise members 6, 7, and 8 turnover and comprise members 6, 7, and 8
Has role	Glutamate receptor +
Id	nlx_mol_20090503 +
Label	Metabotropic Glutamate Receptor +
ModifiedDate	30 December 2009 +
RelatedTo	Glutamate +, and Aspartate +
SuperCategory	G-protein_coupled_receptor +
Synonym	mGluRs +, GRM +, Glutamate metabotropic +, and Metabotropic glutamate +