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Metaraminol

Name: Metaraminol
Description: An adrenergic agonist that acts predominantly at alpha adrenergic receptors and also stimulates the release of norepinephrine. It has been used primarily as a vasoconstrictor in the treatment of hypotension. (PubChem) Pharmacology: Metaraminol is a potent sympathomimetic amine that increases both systolic and diastolic blood pressure. Metaraminol is indicated for prevention and treatment of the acute hypotensive state occurring with spinal anesthesia. It is also indicated as adjunctive treatment of hypotension due to hemorrhage, reactions to medications, surgical complications, and shock associated with brain damage due to trauma or tumor. Metaraminol acts on both 1-adrenergic receptors but appears to have no effect on -adrenergic receptors. It acts by increasing the force of the heart's pumping action as well as constricting peripheral blood vessels. Mechanism of action: Metaraminol acts through peripheral vasoconstriction by acting as a pure alpha-1 adrenergic receptor agonist, consequently increasing systemic blood pressure (both systolic & diastolic). Its effect is thought to be associated with the inhibition of adenyl cyclase which leads to an inhibition of the production of cAMP. Another effect of Metaraminol is that it releases norepinephrine from its storage sites indirectly. Drug type: Approved. Small Molecule. Drug category: Adrenergic Agents. Adrenergic alpha-Agonists. Sympathomimetics. Vasoconstrictor Agents
Synonym(s): Hydroxynorephedrine, L-Metaraminol, M-Hydroxy Norephedrine, M-Hydroxyphenylpropanolamine, M-Hydroxypropadrine, Metaraminol Bitartrate, Metaraminolum (INN-Latin), Metaraminolum (Latin), Aramine, Icoral B, Metaradrine, Pressonex, Pressorol
Has role: Drug
Super-category: Molecular entity
URL: http://www.drugbank.ca/drugs/DB00610
Id: CHEBI_6794
Related to: Alpha-1A adrenergic receptor
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Commenttaken from DrugBank
CurationStatusuncurated  +
CuratorAb  +
DefiningCitationhttp://www.drugbank.ca/drugs/DB00610  +
DefinitionAn adrenergic agonist that acts predominan An adrenergic agonist that acts predominantly at alpha adrenergic receptors and also stimulates the release of norepinephrine. It has been used primarily as a vasoconstrictor in the treatment of hypotension. (PubChem) Pharmacology: Metaraminol is a potent sympathomimetic amine that increases both systolic and diastolic blood pressure. Metaraminol is indicated for prevention and treatment of the acute hypotensive state occurring with spinal anesthesia. It is also indicated as adjunctive treatment of hypotension due to hemorrhage, reactions to medications, surgical complications, and shock associated with brain damage due to trauma or tumor. Metaraminol acts on both 1-adrenergic receptors but appears to have no effect on -adrenergic receptors. It acts by increasing the force of the heart's pumping action as well as constricting peripheral blood vessels. Mechanism of action: Metaraminol acts through peripheral vasoconstriction by acting as a pure alpha-1 adrenergic receptor agonist, consequently increasing systemic blood pressure (both systolic & diastolic). Its effect is thought to be associated with the inhibition of adenyl cyclase which leads to an inhibition of the production of cAMP. Another effect of Metaraminol is that it releases norepinephrine from its storage sites indirectly. Drug type: Approved. Small Molecule. Drug category: Adrenergic Agents. Adrenergic alpha-Agonists. Sympathomimetics. Vasoconstrictor Agents . Sympathomimetics. Vasoconstrictor Agents
Has roleDrug  +
IdCHEBI_6794  +
LabelMetaraminol  +
ModifiedDate14 April 2014  +
RelatedToAlpha-1A adrenergic receptor  +
SuperCategoryMolecular entity  +
SynonymHydroxynorephedrine  +, L-Metaraminol  +, M-Hydroxy Norephedrine  +, M-Hydroxyphenylpropanolamine  +, M-Hydroxypropadrine  +, Metaraminol Bitartrate  +, Metaraminolum (INN-Latin)  +, Metaraminolum (Latin)  +, Aramine  +, Icoral B  +, Metaradrine  +, Pressonex  +, and Pressorol  +