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Metformin

Name: Metformin
Description: A biguanide hypoglycemic agent used in the treatment of non-insulin-dependent diabetes mellitus not responding to dietary modification. Metformin improves glycemic control by improving insulin sensitivity and decreasing intestinal absorption of glucose. (From Martindale, The Extra Pharmacopoeia, 30th ed, p289) Pharmacology: Metformin is an antihyperglycemic agent, which improves glucose tolerance in patients with type 2 diabetes, lowering both basal and postprandial plasma glucose. Metformin is not chemically or pharmacologically related to any other classes of oral antihyperglycemic agents. Unlike sulfonylureas, metformin does not produce hypoglycemia in either patients with type 2 diabetes or normal subjects and does not cause hyperinsulinemia. With metformin therapy, insulin secretion remains unchanged while fasting insulin levels and daylong plasma insulin response may actually decrease. Mechanism of action: Metformin's pharmacologic mechanisms of action are different from other classes of oral antihyperglycemic agents. Metformin decreases hepatic glucose production, decreases intestinal absorption of glucose, and improves insulin sensitivity by increasing peripheral glucose uptake and utilization. Drug type: Approved. Small Molecule. Drug category: Hypoglycemic Agents
Synonym(s): Metformin HCL, metformin hydrochloride, Apo-Metformin, Fortamet, Gen-Metformin, Glucophage, Glucophage XR, Glycon, Novo-Metformin, Nu-Metformin, Riomet
Related to: 5'-AMP-activated protein kinase subunit beta-1
Has role: Drug
Super-category: Molecular entity
URL: http://www.drugbank.ca/drugs/DB00331
Id: CHEBI_6801
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Commenttaken from DrugBank
CurationStatusuncurated  +
CuratorAb  +
DefiningCitationhttp://www.drugbank.ca/drugs/DB00331  +
DefinitionA biguanide hypoglycemic agent used in the A biguanide hypoglycemic agent used in the treatment of non-insulin-dependent diabetes mellitus not responding to dietary modification. Metformin improves glycemic control by improving insulin sensitivity and decreasing intestinal absorption of glucose. (From Martindale, The Extra Pharmacopoeia, 30th ed, p289) Pharmacology: Metformin is an antihyperglycemic agent, which improves glucose tolerance in patients with type 2 diabetes, lowering both basal and postprandial plasma glucose. Metformin is not chemically or pharmacologically related to any other classes of oral antihyperglycemic agents. Unlike sulfonylureas, metformin does not produce hypoglycemia in either patients with type 2 diabetes or normal subjects and does not cause hyperinsulinemia. With metformin therapy, insulin secretion remains unchanged while fasting insulin levels and daylong plasma insulin response may actually decrease. Mechanism of action: Metformin's pharmacologic mechanisms of action are different from other classes of oral antihyperglycemic agents. Metformin decreases hepatic glucose production, decreases intestinal absorption of glucose, and improves insulin sensitivity by increasing peripheral glucose uptake and utilization. Drug type: Approved. Small Molecule. Drug category: Hypoglycemic Agents lecule. Drug category: Hypoglycemic Agents
Has roleDrug  +
IdCHEBI_6801  +
LabelMetformin  +
ModifiedDate14 April 2014  +
RelatedTo5'-AMP-activated protein kinase subunit beta-1  +
SuperCategoryMolecular entity  +
SynonymMetformin HCL  +, metformin hydrochloride  +, Apo-Metformin  +, Fortamet  +, Gen-Metformin  +, Glucophage  +, Glucophage XR  +, Glycon  +, Novo-Metformin  +, Nu-Metformin  +, and Riomet  +